Sharadendu Bali*

Professor General Surgery, TMMC, TMU, Moradabad, UP, India

*Corresponding Author: Sharadendu Bali, Professor General Surgery, TMMC, TMU, Moradabad, UP, India.

Received: March 25, 2024; Published: April 04, 2024

Abstract

Neurogenesis in adult mammals is prominently observed in two specific brain regions: the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurons born in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into interneurons. This migration is important for the sustenance and functional adaptation of the olfactory system, which is unique in its constant turnover of sensory receptor cells. The olfactory system, by its very design, maintains a direct link with the areas of the brain responsible for controlling various behaviors and emotional responses, making it a key component in the sensory-behavioral paradigm influencing adult neurogenesis. This discussion explores the mechanisms through which odors may influence the regeneration and migration of neuronal stem cells to the olfactory bulb (OB) and, consequently, affect neurogenesis.

 Keywords: Rostral Migratory Stream; Neural Stem Cells; Neurogenesis; Fragrance; Aromatherapy

References

1. Jurkowski MP., et al. “Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain”. Frontiers in Cellular Neuroscience 14 (2020): 576444.
2. Van Strien ME., et al. “Migrating neuroblasts in the adult human brain: a stream reduced to a trickle”. Cell Research11 (2011): 1523-1525.
3. Whitman MC., et al. “Adult neurogenesis and the olfactory system”. Progress in Neurobiology 2 (2009): 162-175.
4. Calof AL., et al. “The neuronal stem cell of the olfactory epithelium”. Journal of Neurobiology 36 (1998): 190-205.
5. Rochefort C., et al. “Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory”. Journal of Neuroscience 22 (2002): 2679-2689.
6. Lledo PM and Gheusi G. “Olfactory processing in a changing brain”. NeuroReport 14 (2003): 1655-1663.
7. Rochefort C and Lledo PM. “Short-term survival of newborn neurons in the adult olfactory bulb after exposure to a complex odor environment”. European Journal of Neuroscience 22 (2005): 2863-2870.
8. Yamaguchi M and Mori K. “Critical period for sensory experience-dependent survival of newly generated granule cells in the adult mouse olfactory bulb”. Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 9697-9702.
9. Imayoshi I., et al. “Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain”. Nature Neuroscience 11 (2008): 1153-1161.
10. Mouret A., et al. “Learning and survival of newly generated neurons: when time matters”. Journal of Neuroscience 28 (2008): 11511-11516.
11. Moreno MM., et al. “Olfactory perceptual learning requires adult neurogenesis”. Proceedings of the National Academy of Sciences of the United States of America 106 (2009): 17980.
12. Lazarini F., et al. “Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice”. PLoS One 4 (2009): e7017.
13. Johnson DM., et al. “New features of connectivity in piriform cortex visualized by intracellular injection of pyramidal cells suggest that “primary” olfactory cortex functions like “association” cortex in other sensory systems”. Journal of Neuroscience 20 (2000): 6974-6982.
14. Nacher J., et al. “Doublecortin expression in the adult rat telencephalon”. European Journal of Neuroscience 14 (2001): 629-644.
15. De Marchis S., et al. “Subventricular zone-derived neuronal progenitors migrate into the subcortical forebrain of postnatal mice”. Journal of Comparative Neurology 476 (2004): 290-300.
16. Bédard A., et al. “The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl-2”. European Journal of Neuroscience 16 (2002): 1917-24.
17. Pekcec A., et al. “Neurogenesis in the adult rat piriform cortex”. Neuroreport 17 (2006): 571-574.
18. Shapiro LA., et al. “Olfactory enrichment enhances the survival of newly born cortical neurons in adult mice”. Neuroreport 18 (2007): 981-985.
19. Shapiro LA., et al. “Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex”. Brain Structure and Function 212 (2007): 133-148.
20. Rivers LE., et al. “PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice”. Nature Neuroscience 11 (2008): 1392-1401.
21. Guo F., et al. “Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex”. Journal of Neuroscience 30 (2010): 12036-12049.
22. Kamimura S., et al. “New granule cells in the olfactory bulb are associated with high respiratory input in an enriched odor environment”. Neuroscience Research 182 (2022): 52-59.
23. de la Rosa-Prieto C., et al. “Neurogenesis in subclasses of vomeronasal sensory neurons in adult mice”. Developmental Neurobiology 70 (2010): 961-970.
24. Oboti L., et al. “Integration and sensory experience-dependent survival of newly-generated neurons in the accessory olfactory bulb of femalemice”. European Journal of Neuroscience 29 (2009): 679-692.
25. Price JL. “Comparative aspects of amygdala connectivity. The amygdala in brain function: basic and clinical approaches”. Annals of the New York Academy of Sciences 985 (2003): 50-58.
26. Shapiro LA., et al. “Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions”. Epilepsy and Behavior 14 (2009): 74-80.
27. Bernier PJ., et al. “Newly generated neurons in the amygdala and adjoining cortex of adult primates”. Proceedings of the National Academy of Sciences of the United States of America 99 (2022): 11464-11469.
28. Keilhoff G., et al. “Cell proliferation is influenced by bulbectomy and normalized by imipramine treatment in a region-specific manner”. Neuropsychopharmacology 31 (2006): 1165-1176.
29. Song C and Leonard BE. “The olfactory bulbectomised rat as a model of depression”. Neuroscience and Biobehavioral Reviews 29 (2005): 627-647.
30. Jaako-Movits K and Zharkovsky A. “Impaired fear memory and decreased hippocampal neurogenesis following olfactory bulbectomy in rats”. European Journal of Neuroscience 22 (2005): 2871-2878.
31. Kevetter GA and Winans SS. “Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the “vomeronasal amygdala”. Journal of Comparative Neurology 197 (1981): 81-98.v
32. Kang N., et al. “A direct main olfactory bulb projection to the ‘vomeronasal’ amygdala in female mice selectively responds to volatile pheromones from males”. European Journal of Neuroscience 29 (2009): 624-634.
33. Fowler CD., et al. “Estrogen and adult neurogenesis in the amygdala and hypothalamus”. Brain Research Reviews 57 (2008): 342-351.
34. Bédard A., et al. “Chemical characterization of newly generated neurons in the striatum of adult primates”. Experimental Brain Research 1701 (2006): 501-512.

35.   Cansler HL., et al. “Neurochemical organization of the ventral striatum’s olfactory tubercle”. Journal of Neurochemistry 152.4 (2020): e14919.

36. Haber SN., et al. “Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning”. Journal of Neuroscience 26 (2006): 8368-8376.
37. Balleine BW., et al. “The role of the dorsal stratum in reward and decision-making”. Journal of Neuroscience 31 (2007): 8161-8165.
38. Schwerdtfeger WK., et al. “Disynaptic olfactory input to the hippocampus mediated by stellate cells in the entorhinal cortex”. Journal of Comparative Neurology 292 (1990): 163-177.
39. Kajiwara R., et al. “Olfactory information converges in the amygdaloid cortex via the piriform and entorhinal cortices: observations in the guinea pig isolated whole-brain preparation”. European Journal of Neuroscience 25 (2007): 3648-3658.
40. Zhang XM., et al. “Doublecortinexpressing cells persist in the associative cerebral cortex and amygdala in aged nonhuman primates”. Frontiers in Neuroanatomy 3 (2009): 17.
41. Mak GK., et al. “Male pheromone-stimulated neurogenesis in the adult female brain: possible role in mating behavior”. Nature Neuroscience 10 (2007): 1003-1011.
42. Cherng CG., et al. “Presence of conspecifics and their odor-impregnated objects reverse stress-decreased neurogenesis in mouse dentate gyrus”. Journal of Neurochemistry 112 (2010): 1138-1146.
43. Ruscio MG., et al. “Pup exposure elicits hippocampal cell proliferation in the prairie vole”. Behavioural Brain Research 187 (2008): 9-16.
44. Mak GK and Weiss S. “Paternal recognition of adult offspring mediated by newly generated CNS neurons”. Nature Neuroscience 13 (2010): 753-758.
45. Tanapat P., et al. “Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus”. International Journal of Developmental Neuroscience 16 (1998): 235-239.
46. Tanapat P., et al. “Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism”. Journal of Comparative Neurology 437 (2001): 496-504.
47. Holmes MM and Galea LA. “Defensive behavior and hippocampal cell proliferation: differential modulation by naltrexone during stress”. Behavioral Neuroscience 116 (2002): 160-168.
48. Falconer EM and Galea LA. “Sex differences in cell proliferation, cell death and defensive behavior following acute predator odor stress in adult rats”. Brain Research 975 (2003): 22-36.
49. Thomas RM., et al. “Acute exposure to predator odor elicits a robust increase in corticosterone and a decrease in activity without altering proliferation in the adult rat hippocampus”. Experimental Neurology 201 (2003): 308-315.
50. Spritzer MD., et al. “Prior sexual experience increases hippocampal cell proliferation and decreases risk assessment behavior in response to acute predator odor stress in the male rat”. Behavioural Brain Research 200 (2009): 106-112.
51. Gould E., et al. “Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress”. Proceedings of the National Academy of Sciences of the United States of America 95 (1988): 3168-3171.
52. Gould E., et al. “Learning enhances adult neurogenesis in the hippocampal formation”. Nature Neuroscience 2 (1999): 260-265.
53. Gould E., et al. “Neurogenesis in adulthood: a possible role in learning”. Trends in Cognitive Sciences 3 (1999): 186-192.
54. Shors TJ., et al. “Neurogenesis in the adult is involved in the formation of trace memories”. Nature 410 (2001): 372-376.
55. Shors TJ., et al. “Neurogenesis may relate to some but not all types of hippocampal-dependent learning”. Hippocampus 12 (2002): 578-584.
56. Snyder JS., et al. “A role for adult neurogenesis in spatial long-term memory”. Neuroscience 130 (2005): 843-852.
57. Leuner B., et al. “Is there a link between adult neurogenesis and learning?” Hippocampus 16 (2006): 216-24.
58. Huart C., et al. “Plasticity of the human olfactory system: the olfactory bulb”. Molecules (Basel, Switzerland) 9 (2013): 11586-11600.
59. Corotto FS., et al. “Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse”. Neuroscience 61 (1994): 739-744.
60. Cummings DM and Brunjes PC. “The effects of variable periods of functional deprivation on olfactory bulb development in rats”. Experimental Neurology 148 (1997): 360-366.
61. Lledo PM and Valley M. “Adult Olfactory Bulb Neurogenesis”. Cold Spring Harbor Perspectives in Biology8 (2016): a018945.
62. Hickey K and Stabenfeldt SE. “Using biomaterials to modulate chemotactic signaling for central nervous system repair”. Biomedical Materials (Bristol, England) 4 (2018): 044106.
63. Lim DA and Alvarez-Buylla A. “The Adult Ventricular-Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis”. Cold Spring Harbor Perspectives in Biology5 (2016): a018820.
64. Bergmann O., et al. “The age of olfactory bulb neurons in humans”. Neuron 74 (2012): 634-639.
65. Curtis MA., et al. “Neurogenesis in humans”. European Journal of Neuroscience 33 (2011): 1170-1174.
66. Altman J. “Autoradiographic and histological studies of postnatal neurogenesis. 4. Cell proliferation and migration in anterior forebrain, with special reference to persisting neurogenesis in olfactory bulb”. Journal of Comparative Neurology 137 (1969): 433-457.
67. Luskin MB. “Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone”. Neuron 11 (1993): 173-189.
68. Lois C and Alvarez-Buylla A. “Long-distance neuronal migration in the adult mammalian brain”. Science 264 (1994): 1145-1148.
69. Breton-Provencher V., et al. “Interneurons produced in adulthood are required for the normal functioning of the olfactory bulb network and for the execution of selected olfactory behaviors”. Journal of Neuroscience 29 (2009): 15245-15257.
70. Vanden Berg-Foels WS. “In situ tissue regeneration: chemoattractants for endogenous stem cell recruitment”. Tissue Engineering Part B: Reviews 1 (2014): 28-39.
71. Yoon D., et al. “Study on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices”. Biomaterial Research20 (2016): 25.
72. Perry C. “Olfactory pathway and nerve. Anatomy.

Citation

Citation: Sharadendu Bali. “The Scent of Neurogenesis: Refurbish Your Brain the Pleasurable Way”.Acta Scientific Medical Sciences 8.5 (2024): 02-11.

Copyright

Copyright: © 2024 Sharadendu Bali. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.