Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 8 Issue 1

Human Pancreatic Islet Gene View in glucose homeostasis of Diabetic and Non-Diabetic Pancreases in the Indian population

Nithyakalyani Mohan1*, Anusha Sunder2, Kandappa Himakar Reddy3 and Ponnuraja C4

1Transplant and Research, Apollo Hospitals, Chennai, Tamilnadu, India
2Research Associate, Apollo Hospital and Research Foundation, Chennai, Tamilnadu, India
3Molecular Biologist Associate, Siruseri Biotech Park for Women, Chennai, Tamilnadu, India
4Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, Tamilnadu, India

*Corresponding Author: Nithyakalyani Mohan, Senior Scientist, Transplant and Research, Apollo Hospitals, Chennai, Tamilnadu, India.

Received: December 14, 2023; Published: December 29, 2023

Abstract

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in pro-peptide processing and secretory function, along with the loss of these vital cells, are demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Due to ethical and practical difficulties, genomic or pathological data in Indian population are remarkably missing. Here we report genome transcript analysis validated by quantitative reverse transcription–polymerase chain reaction (qRT–PCR) for 21 pancreases. We analysed clinical-pathological features of 21 pancreases with the expression pattern of various genes which were involved in the glucose homeostasis in order to understand their prognostic value. We also investigated the pathological differences between diabetic and non-diabetic samples and the expression of insulin in each case. This study provides an insight into the complex pattern of the gene expression disturbances that occur in the diabetic and non-diabetic pancreas.

 Keywords: Diabetes; Beta Cells; Islets; Genes; Pathological; Glucose Homeostasis; Human Pancreas

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Citation

Citation: Nithyakalyani Mohan., et al. “Human Pancreatic Islet Gene View in glucose homeostasis of Diabetic and Non-Diabetic Pancreases in the Indian population”.Acta Scientific Medical Sciences 8.1 (2024): 114-121.

Copyright

Copyright: © 2024 Nithyakalyani Mohan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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