Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 11

Association of Low Salivary Secretory Immunoglobulin A Levels with Symptomatic Allergic Rhinitis in Adolescents and Adults

Tetsuro Yamamoto1,2, Tadao Enomoto3, Hiroyasu Shimada4, Atsushi Kotani1,2, Kazuki Tajima1,2, Kunihiko Wasaki1,2,4 and Hideyo Yamaguchi5*

1Innovation Research Center, EPS Holdings Inc., Japan
2Research Center, EPS Innovative Medicine Co., Ltd., Japan
3NPO Japan Health Promotion Supporting Network, Japan
4EP Mediate Co., Ltd, Japan
5Emeritus Professor, Institute of Medical Mycology, Teikyo University, Japan

*Corresponding Author: Hideyo Yamaguchi, Emeritus Professor, Institute of Medical Mycology, Teikyo University, Japan.

Received: September 28, 2023; Published: October 26, 2023

Abstract

Over the last decades, the incidence of allergic rhinitis (AR) has revealed a constantly increasing tendency worldwide. In Japan, Japanese cedar pollinosis (JCP) and perennial allergic rhinitis (PAR) mostly due to mite allergens are the predominant types of seasonal and nonseasonal ARs, respectively. We previously reported a relationship between low levels of secretory immunoglobulin A (sIgA) in saliva and clinical AR manifestations in adult patients with JCP. To confirm and extend our previous study, we conducted a cross-sectional study, in which salivary sIgA levels in adolescent and adult patients with symptomatic JCP and PAR were compared with levels in age- and gender-matched non-allergic control individuals during the Japanese cedar pollen dispersing season. The results showing the significantly lower salivary sIgA levels in JCP and PAR patients compared to control individuals led us to the conclusion that there is a negative correlation between salivary sIgA levels and clinical occurrence of AR in adolescents and adults. Moreover, it was also found that age and gender have no significant effect on salivary sIgA levels.

 Keywords: Allergic Rhinitis; Immunoglobulin A; Japanese Cedar Pollinosis; Mucosal Immunity; Perennial Allergic Rhinitis; Saliva; Secretory Immunoglobulin A

References

  1. Cerutti A., et al. “Immunoglobulin responses at the mucosal interface”. Annual Review of Immunology 29 (2011): 273-279.
  2. Bo ttcher M., et al. “Total and allergen-specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age”. Clinical and Experimental Allergy 32 (2003): 293-298.
  3. Kaetzel CS. “The polymeric immunoglobulin receptor : bridging innate and adaptive immune responses at mucosal surfaces”. Immunological Review 206 (2005): 83-99.
  4. Corthe sy B. “Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces”. Future Microbiology 5 (2010): 817-829.
  5. Boyaka PN. “Inducing mucosal IgA: A challenge for vaccine adjuvants and delivery systems”. Journal of Immunology 199 (2017): 9-16.
  6. Hammarstrom L., et al. “Selective IgA deficiency (SIgAD) and common variable Immunodeficiency (CVID)”. Clinical and Experimental Immunology 120 (2000): 225-231.
  7. Cunningham-Rundles C. “Physiology of IgA and IgA deficiency”. Journal of Clinical Immunology 21 (2001): 303-309.
  8. Janzi M., et al. “Selective IgA deficiency in early life: Association to infections and allergic diseases during childhood”. Clinical Immunology 133 (2009): 78-85.
  9. Morawska I., et al. “The epidemiology and clinical presentations of atopic diseases in selective IgA deficiency”. Journal of Clinical Medicine 10 (2021): 3809.
  10. Cinicola BL., et al. “Selective IgA deficiency and allergy: A fresh look to an old story”. Medicina 58 (2022): 129.
  11. Van Cauwenberge P., et al. “Consensus statement on the treatment of allergic rhinitis”. Allergy 55 (2000): 116-134.
  12. Bousguet N., et al. “Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen)”. Allergy86 (2008): 8-160.
  13. Fujieda S., et al. “Examination, diagnosis and classification for Japanese allergic rhinitis : Japanese guideline”. Auris Nasus Larynx 39 (2012): 553-556.
  14. K., et al. “Japanese guidelines for allergic rhinitis 2017”. Allergology International 66 (2017): 205-219.
  15. Sakashita M., et al. “Prevalence of allergic rhinitis and sensitization to common aeroallergens in a Japanese population”. International Archives of allergy and Immunology 151 (2010): 255-261.
  16. Okubo k., et al. “Japanese guidelines for allergic rhinitis 2014”. Allergology International 63 (2014): 357-375.
  17. Matsubara A., et al. “Epidemiological survey of allergic rhinitis in Japan 2019”. Nippon Jibiinkoka Gakkai kaiho (Tokyo) 123 (2020): 485-490.
  18. Yamamoto T., et al. “The relationship between allergic pollinosis and low salivary levels of secretory IgA in adults”. Acta Scientific Nutritional Health 4 (2020): 16-21.
  19. Lu dví ksson BR., et al. “Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants”. Journal of Pediatrics 121 (1992): 23-27.
  20. Cortesina G., et al. “Mucosal immunity in allergic rhinitis”. Acta Otolaryngology (Stockholm) 113 (1993): 397-399.
  21. Calvo M., et al. “Evaluation of secretory IgA in childhood respiratory diseases”. Allergologia et Immunopathologia 16 (1988): 157-161.
  22. Gleeson M., et al. “Development of bronchial hyperreactivity following transient absence of salivary IgA”. American Journal of Respiratory and Critical Care Medicine 153 (1996): 1785-1789.
  23. Aghamohammadi A., et al. “IgA deficiency: correlation between clinical and immunological phenotypes”. Journal of Clinical Immunology 29 (2009): 130-136.
  24. Sandin A., et al. “High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants”. Pediatric Allergy and Immunology 2 (2011): 477-481.
  25. Tani-Ishii N., et al. “Effect of salivary secretion with mouthguard use on seasonal allergic rhinitis symptom improvement”. Journal of Oral Bioscience 62 (2020): 205-211.
  26. Yamamoto T., et al. “The function of secretory immunoglobulin A (sIgA) in saliva protecting against microbial infections and allergic diseases and potential measures to enhance sIgA secretion”. Japanese Pharmacological Therapy 49 (2021): 533-562.
  27. Kugler J ., et al. “Secretion of salivary immunoglobulin A in relation to age, saliva flow, mood states, secretion of albumin, cortisol, and catecholamines in saliva”. Journal of Clinical Immunology 12 (1992): 45-49.
  28. Widerstro m L., et al. “Increased IgA levels in saliva during pregnancy”. Scandinavian Journal of Dental Research 92 (1984): 33-37.
  29. Jafarzadeh A., et al. “Salivary IgA and IgE levels in healthy subjects : relation to age and gender”. Brazilian Oral Research 24 (2010).
  30. Miletic ID., et al. “Salivary IgA secretion rate in young and elderly persons”. Physiological Behavior 1 (1996): 243-248.
  31. Smith DJ., et al. “Effect of age on immunoglobulin content and volume of human labial gland saliva”. Journal of Dental Research 71 (1992): 1891-1894.
  32. Challacombe SJ., et al. “Age- related changes in immunoglobulin isotypes in whole and parotid saliva and serum in healthy individuals”. Oral Microbiology and Immunology 10 (1995): 202-207.
  33. Evans P., et al. “Social class, sex and age differences in mucosal immunity in a large community sample”. Brain Behavior and Immunity 14 (2000): 41-48.

Citation

Citation: Hideyo Yamaguchi., et al. “Association of Low Salivary Secretory Immunoglobulin A Levels with Symptomatic Allergic Rhinitis in Adolescents and Adults”.Acta Scientific Medical Sciences 7.11 (2023): 118-124.

Copyright

Copyright: © 2023 Hideyo Yamaguchi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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