Tetsuro Yamamoto^1,2, Tadao Enomoto³, Hiroyasu Shimada⁴, Atsushi Kotani^1,2, Kazuki Tajima^1,2, Kunihiko Wasaki^1,2,4 and Hideyo Yamaguchi⁵*

¹Innovation Research Center, EPS Holdings Inc., Japan
²Research Center, EPS Innovative Medicine Co., Ltd., Japan
³NPO Japan Health Promotion Supporting Network, Japan
⁴EP Mediate Co., Ltd, Japan
⁵Emeritus Professor, Institute of Medical Mycology, Teikyo University, Japan

*Corresponding Author: Hideyo Yamaguchi, Emeritus Professor, Institute of Medical Mycology, Teikyo University, Japan.

Received: September 28, 2023; Published: October 26, 2023

Abstract

Over the last decades, the incidence of allergic rhinitis (AR) has revealed a constantly increasing tendency worldwide. In Japan, Japanese cedar pollinosis (JCP) and perennial allergic rhinitis (PAR) mostly due to mite allergens are the predominant types of seasonal and nonseasonal ARs, respectively. We previously reported a relationship between low levels of secretory immunoglobulin A (sIgA) in saliva and clinical AR manifestations in adult patients with JCP. To confirm and extend our previous study, we conducted a cross-sectional study, in which salivary sIgA levels in adolescent and adult patients with symptomatic JCP and PAR were compared with levels in age- and gender-matched non-allergic control individuals during the Japanese cedar pollen dispersing season. The results showing the significantly lower salivary sIgA levels in JCP and PAR patients compared to control individuals led us to the conclusion that there is a negative correlation between salivary sIgA levels and clinical occurrence of AR in adolescents and adults. Moreover, it was also found that age and gender have no significant effect on salivary sIgA levels.

 Keywords: Allergic Rhinitis; Immunoglobulin A; Japanese Cedar Pollinosis; Mucosal Immunity; Perennial Allergic Rhinitis; Saliva; Secretory Immunoglobulin A

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Citation

Citation: Hideyo Yamaguchi., et al. “Association of Low Salivary Secretory Immunoglobulin A Levels with Symptomatic Allergic Rhinitis in Adolescents and Adults”.Acta Scientific Medical Sciences 7.11 (2023): 118-124.

Copyright

Copyright: © 2023 Hideyo Yamaguchi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.