Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 7 Issue 11

Vitis vinifera Seeds: Phytochemical Compounds and Pharmacological Properties. A Review

Burhan Z Fakhurji1,2*, Isam M Abu Zeid1,3 and Atef M Al-Attar1,3

1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi Arabia
2iGene Medical Research and Training Center, Saudi Arabia
3Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Saudi Arabia

*Corresponding Author: Burhan Z Fakhurji, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Saudi Arabia.

Received: September 25, 2023; Published: October 18, 2023

Abstract

One of the most prominent and valuable fruits is grapes. Grape muscadine seeds possess a broad spectrum of pharmacological potential. The antioxidant potential was shown to be the highest in grape seed compounds. Consumption of proanthocyanidin grapes decreased foam-cell growth in hamsters. Bacteria of both gram-positive and gram-negative varieties were entirely stopped in their tracks by grape seed extracts. Total phenolic content was highest in grape seed extracts, while it was lowest in skin crude extract. Nevertheless, it was found that skin extracts were more beneficial than seed extracts in controlling Helicobacter pylori. It is proposed that supplementing grape seed can be an efficient anti- carcinogenic therapy in medical practice. Vitis vinifera seed oil contains flavonoids, carotenoid, phenolic, tannin, and stilbene compounds. The total quantity of polyphenolscollected by the cold-pressure method from Vitis Vinaifera seed oilis approximately 2.9 mg/kg. Grape seed oils extracted using a cooler pressing method are rich in linoleic acid (LIA). The oil is rich in polyunsaturated fatty acids (PUFA). Vitis vinaifera seed oil has potential as a healthy alternative anti-inflammatory treatment. Serious illnesses linked with worldwide-elevated mortality and morbidity rates are commonly associated with inflammatory mechanisms. Grape seed oil also has an impact on certain bacteria, showing an antimicrobial character. Subsequent generations of antimicrobial drugs for use in food and medicine could be transmitted through oil extracted from the Vitis vinifera plant.

 Keywords: Vitis vinifera; Oil; Bioactive Compounds; Antioxidant Effects; Pharmacological Properties

References

  1. Unusan N. “Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry”. Journal of Functional Foods 1 (2020): 103861.
  2. FAO-OIV, Focus 2016 Table and Dried Grapes (2016). 
  3. Girard B and Mazza G. “Functional grape and citrus products, 1998”. Technomic Publishing: Lancaster, (1998).
  4. Weseler AR and Bast A. “Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits”. Nutrition Journal 16 (2017): 5.
  5. Ferrer-Gallego R., et al. “Determination of phenolic compounds of grape skins during ripening by NIR spectroscopy”. LWT 1 (2011): 847-853.
  6. Cuevas VM., et al. “Effects of grape seed extract, vitamin C, and vitamin E on ethanol-and aspirin-induced ulcers”. Advances in Pharmacological and Pharmaceutical Sciences (2011).
  7. Rodríguez-Montealegre R., et al. “Phenolic compounds in skins and seeds of ten grape Vitis vinifera varieties grown in a warm climate”. Journal of Food Composition and Analysis 19 (2006): 687-693.
  8. Zhou DD., et al. “Bioactive compounds, health benefits and food applications of grape”. Foods 11 (2022): 2755.
  9. Zhu F., et al. “Advance on the bioactivity and potential applications of dietary fibre from grape pomace”. Food Chemistry 186 (2015): 207-12.
  10. Chemat F., et al. “Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review”. Ultrasonics Sonochemistry 34 (2017): 540-560.
  11. Bjelica M., et al. “Some chemical characteristics and oxidative stability of cold pressed grape seed oils obtained from different winery waste”. European Journal of Lipid Science and Technology 121 (2019): 1800416.
  12. Shinagawa T., et al. “Insight on Tafel slopes from a microkinetic analysis of aqueous electrocatalysis for energy conversion”. Scientific Report 5 (2015): 13801.
  13. Ananga A., et al. “Grape seed nutraceuticals for disease prevention: Current status and future prospects”. Phenolic Compounds–Biological Activity (2017): 119-137.
  14. Preuss HG., et al. “Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study”. Journal of Medicine5-6 (2000): 227-246.
  15. Jayaprakasha GK., et al. “Antibacterial and antioxidant activities of grape (Vitis vinifera) seed extracts”. 
  16. Food Research International 36 (2003): 117-122.
  17. Puiggròs F., et al. “Grape seed procyanidins prevent oxidative injury by modulating the expression of antioxidant enzyme systems”. Journal of Agricultural and Food Chemistry 53 (2005): 6080-6086.
  18. Guo L., et al. “Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells”. Journal of Agricultural and Food Chemistry 55 (2007): 5881-5891.
  19. Vinson JA., et al. “Beneficial effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model”. Molecular and Cellular Biochemistry 240 (2002): 99-103.
  20. Guo L., et al. “Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells”. Journal of Agricultural and Food Chemistry 55 (2007): 5881-5891.
  21. Petrescu M., et al. “Chronic inflammation—a Link between nonalcoholic fatty liver disease (NAFLD) and dysfunctional adipose tissue”. Medicina 58 (2022): 641.
  22. Regidor PA., et al. “PCOS: A chronic disease that fails to produce adequately specialized pro-resolving lipid mediators (SPMs)”. Biomedicines10 (2022): 456.
  23. Fernández-Fernández AM., et al. “Potential of red winemaking byproducts as health-promoting food ingredients”. In sustainable innovation in food product design. Springer, Cham (2021): 205-248.
  24. Mariné-Casadó R., et al. “Maternal supplementation with a cocoa extract during lactation deeply modulates dams’ metabolism, increases adiponectin Circulating levels and improves the inflammatory profile in obese rat offspring”. Nutrients14 (2022): 5134.
  25. Dasiman R., et al. “A review of procyanidin: Updates on current bioactivities and potential health benefits”. Biointerface Research in Applied Chemistry 12 (2022): 5918-5940.
  26. Mahdipour R., et al. “The benefits of grape seed extract in neurological disorders and brain aging”. Nutrition and Neuroscience (2022): 1-15.
  27. Majeed T and Bhat NA. “Health benefits of plant extracts”. In plant extracts: applications in the food industry. Academic Press, 269-294.
  28. Abdul-Hamid M., et al. “Effect of gervital in attenuating hepatotoxicity caused by methotrexate or azathioprine in adult albino rats.” Environmental Science and Pollution Research volume (2022): 1-14.
  29. Bahram PG., et al. “Effect of supplementation with grape seed (Vitis vinifera) extract on antioxidant status and lipid peroxidation in patient with type Ι Ι diabetes”. Journal of Medicinal Plants Research 5 (2011): 2029-2034.
  30. Gianazza E., et al. “Lipid peroxidation in atherosclerotic cardiovascular diseases”. Antioxidants & Redox Signaling 34 (2021): 49-98.
  31. Al-Otibi F., et al. “The antimicrobial activities of silver nanoparticles from aqueous extract of grape seeds against pathogenic bacteria and fungi”. Molecules26 (2021): 6081.
  32. Mauro M., et al. “Chitosan film functionalized with grape seed oil—preliminary evaluation of antimicrobial activity”. Sustainability14 (2022): 5410.
  33. Ghouila Z., et al. “Antioxidant, antibacterial and cell toxicity effects of polyphenols Fromahmeur bouamer grape seed extracts”. Journal of Fundamental and Applied Sciences9 (2017): 392-420.
  34. Kang S., et al. “In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus plantarum pH3A, monolaurin, and grapefruit seed extract”. Food Function 12 (2021): 11024-11032.
  35. Manso T., et al. “Antimicrobial activity of polyphenols and natural polyphenolic extracts on clinical isolates”. Antibiotics 11 (2021): 46.
  36. Yan J., et al. “In-vitro anti-Helicobacter pylori activity and preliminary mechanism of action of Canarium album fruit extracts”. Journal of Ethnopharmacology283 (2022): 114578.
  37. Xu Y., et al. “Grape seed proanthocyanidins play the roles of radioprotection on normal lung and radiosensitization on lung cancer via differential regulation of the MAPK signaling pathway”. Cancer 12 (2021): 2844.
  38. Habib HM., et al. “Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities”. Scientific Report 12 (2022): 1-14.
  39. Kalinowska M., et al. “Comparing the extraction methods, chemical composition, phenolic contents and antioxidant activity of edible oils from Cannabis sativa and Silybum marianu seeds”. Scientific Report12 (2022): 1-16.
  40. Pavlić B., et al. “Sustainable raw materials for efficient valorization and recovery of bioactive compounds”. Industrial Crops and Products193 (2023): 116167.
  41. Garavaglia J., et al. “Grape seed oil compounds: Biological and chemical actions for health”. Nutrition and Metabolic Insights 9 (2016): 32910.
  42. Da Mata IR., et al. “Different biological activities (antimicrobial, antitumoral, and antioxidant activities) of grape seed oil”. In multiple biological activities of unconventional seed oils. Academic Press (2022): 215-227.
  43. Górnaś P., et al. “Free and esterified tocopherols, tocotrienols and other extractable and non-extractable tocochromanol-related molecules: Compendium of knowledge, future perspectives and recommendations for chromatographic techniques, tools, and approaches used for tocochromanol determination”. Molecules 27 (2022): 6560.
  44. Caetano SSP., et al. “Characterization and bioactive compounds of organic Bordeaux grape seed oil and flours (Vitis labrusca)”. Research, Society and Development 11 (2022): 55111435888.
  45. Lončarević I., et al. “Cocoa spread with grape seed oil and encapsulated grape seed extract: impact on physical properties, sensory characteristics and polyphenol content”. Foods 11 (2022): 2730.
  46. Alfaia CM., et al. “Use of grape by-products to enhance meat quality and nutritional value in monogastrics”. Foods 11 (2022): 2754.
  47. Bjørklund G., et al. “Natural compounds and products from an anti-aging perspective”. Molecules 27 (2022): 7084.

Citation

Citation: Burhan Z Fakhurji., et al.Vitis vinifera Seeds: Phytochemical Compounds and Pharmacological Properties. A Review”.Acta Scientific Medical Sciences 7.11 (2023): 74-80.

Copyright

Copyright: © 2023 Burhan Z Fakhurji., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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