Chernorotov VA, Kosnenich VS* and Zvegintsev RR

Institution “Medical Academy Named After S.I. Georgievsky” of Vernadsky CFU, Simferopol, Russia

*Corresponding Author: Kosnenich VS, Institution “Medical Academy Named After S.I. Georgievsky” of Vernadsky CFU, Simferopol, Russia.

Received: September 11, 2023; Published: October 11, 2023

Abstract

Prostate cancer (PC) is one of the most common malignancies in men. Every year, 34,540 (5.5%) new cases of prostate cancer are diagnosed in India, making it the 7th most common malignancy in the male population, with annual mortality rate 16.783 (5.4%) patients. Tumour neoangiogenesis is the cause of delayed diagnosis and choice of treatment and rehabilitation according to various studies. Monitoring changes in tumour vascular pattern is currently a fundamental problem in oncology, and microvascular density is considered to be the «gold standard» in assessing neoangiogenesis and the aggressiveness of many cancers. Perfusion computed tomography is a relatively recently developed technique that allows quantitative and qualitative assessment of haemodynamic changes in tumour neoangiogenesis.

During the study, 45 patients with morphologically verified PCa were included in the final sample. The mean age of patients was 63 ± 13 years, serum PSA level was 15.41 ± 7.32 ng/ml, final PiRADS score >4, Gleason score >8. Taking into account data from world literature and their own experience, the authors proposed a modified evaluation algorithm. Statistical analysis of sensitivity, specificity and accuracy of CT-perfusion method was performed in the study.

Blood volume (BV) and blood flow (BF) were found to be statistically significant parameters for PCa diagnosis, while mean time to flow (MTT) and permeability (PS) showed no statistically significant differences between healthy tissue and “hot spots”. A statistical analysis of the sensitivity, specificity, and accuracy of the CT perfusion method has been carried out. The prospects for using the method in choosing treatment and rehabilitation tactics among patients with localized PCa were noted.

CT perfusion demonstrates high indices of sensitivity and specificity in PCa diagnostics (86.96% and 62.50% respectively) and may be used as an instrumental PCa diagnostic method in future. However, it has drawbacks such as high radiation exposure and limited capabilities in soft tissue assessment. The prospects of using this method as a multimodal approach in the planning of treatment and rehabilitation tactics for patients with prostate cancer are noted.

 Keywords: Blood Volume; Blood Flow; Mean Transit Time; Permeability; Localised Prostate Cancer; CT Perfusion

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Citation

Citation: Kosnenich VS., et al. “CT Perfusion as New Modality in the Arsenal of Diagnostics for Advanced Prostate Cancer”.Acta Scientific Medical Sciences 7.11 (2023): 14-19.

Copyright

Copyright: © 2023 Kosnenich VS., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.