Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 10

Possible Correlation Between ANA Positivity and Neoplasms in the Elderly: Preliminary Results

Leonardo DO Carmo Nakamura1, Letycia Sette Vieira1, Gabriele Monteiro2 and Zamir Calamita3*

1Graduation - Marília Medical School (FAMEMA) - Marília - São Paulo - Brazil
2Biomedical - Blood Center - FAMEMA - Marília - São Paulo - Brazil
3Medical Immunologist - PhD - Department of Immunology and Allergy - FAMEMA - Marília, São Paulo, Brazil

*Corresponding Author: Zamir Calamita, Medical Immunologist - PhD - Department of Immunology and Allergy - FAMEMA - Marília, São Paulo, Brazil.

Received: July 18, 2023; Published: September 14, 2023

Abstract

This is a case-control study in which elderly patients were compared regarding the presence or absence of neoplasms, dependent or not on ANA positivity. The control was composed of those with negative ANA and the group of cases was composed with those with positive ANA in low to moderate titers. The information was collected from a database of the immunology sector of the Blood Center of the Marília Medical School, state of São Paulo, Brazil. We evaluated 31 ANA positive patients (cases) and 36 ANA negative (controls). An OR = 1.93 (95% CI= 0.66 – 5.65) was found indicating a favorable trend for the association between ANA positivity and the presence of neoplasms, but without statistical significance. We believe more research is needed with larger samples in the study of this subject.

 Keywords: Antinucleus Factor; Coarse Speckled (CS); Drugs

References

  1. Dellavance A and Andrade LEC. “Como interpretar e valorizar adequadamente o teste de anticorpos antinúcleo”. Jornal Brasileiro de Patologia e Medicina Laboratorial 43 (2007): 157-168.
  2. Cezar JPL., et al. “O Teste do Fator Antinúcleo (FAN) na prática clínica: quando solicitar e como interpretar”. Acta Médica (Porto Alegre) 34 (2013): 6.
  3. Health BCMo. “Antinuclear Antibody (ANA) Testing Protocol Internet” (2013).
  4. Torres P. Entenda o que é o exame: FAN – Fator antinuclear: Associação Brasileira Superando Lupus; (2018).
  5. Dellavance A., et al. “3º Consenso Brasileiro para pesquisa de autoanticorpos em células HEp-2 (FAN): recomendações para padronização do ensaio de pesquisa de autoanticorpos em células HEp-2, controle de qualidade e associações clínicas”. Revista Brasileira de Reumatologia 49 (2009): 89-98.
  6. Sun Q., et al. “Presence of serum antinuclear antibodies correlating unfavorable overall survival in patients with chronic lymphocytic leukemia”. Chinese Medical Journal5 (2019): 525-533.
  7. Skare TL., et al. “Antinuclear antibodies in patients with cervical lesions and invasive cervical cancer”. Immunology Letter 208 (2019): 8-10.
  8. Paradella R. Número de idosos cresce 18% em 5 anos e ultrapassa 30 milhões em 2017 Agência de notícias IBGE (2018).
  9. Fêde ABdS., et al. “A importância das neoplasias na população idosa brasileira de 2000 a 2005”. Einstein (2009): 6.

Citation

Citation: Zamir Calamita., et al. “Possible Correlation Between ANA Positivity and Neoplasms in the Elderly: Preliminary Results”.Acta Scientific Medical Sciences 7.10 (2023): 34-37.

Copyright

Copyright: © 2023 Zamir Calamita., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US