Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 9

The Neonates' Body Length and Body Weight in Two Different Periods of Time

Nusrat Zerin1*, Sharmin Sultana1, Farhana Afroz2, Mahfuja Rahman1 and Sabrina Afrin Chowdhury3

1Lecturer, Department of Biochemistry, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
2Assistant Professor, Department of Biochemistry, Sheikh Hasina National Institute of Burn and Plastic Surgery
3Assistant Professor, Department of Biochemistry, Northern International Medical College, Dhaka, Bangladesh

*Corresponding Author: Nusrat Zerin, Lecturer, Department of Biochemistry, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh. Email: lizu.khan@gmail.com.

Received: July 31, 2023; Published: August 16, 2023

Abstract

Background: Diabetes Mellitus is a leading cause of death and disability world wide. Glycated haemoglobin (HbA1c) is recommended for screening and diagnosis of Type 2 Diabetes Mellitus. Iron is a transitional metal and a potential catalyst in cellular reactions that produces reactive oxygen species. Ferritin is an index of body iron stores and acts as an iron overload marker. Many cross sectional studies suggest a link between body iron excess and insulin metabolism.

Objectives: To evaluate the association of iron status parameters with glycemic status in Type 2 DM.

Methods: A cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College (DMC), Dhaka; from July 2015 to June 2016. According to selection criteria a total 50 diagnosed patients of Type 2 DM attending in the Department of Endocrinology & Metabolism, Dhaka Medical College Hospital were selected as Group A and same number of age and sex matched apparently healthy individuals were selected (from same hospital staff, patient attendants and visitors by personal contact) as Group B. All the study subjects were subjected to detailed clinical history, physical examinations and laboratory biochemical investigations. After an overnight fast venous sample was taken from all subjects. Fasting plasma glucose was estimated enzymatically by glucose oxidase method, Glycated hemoglobin was measured by high performance liquid chromatography and estimation of serum iron, serum ferritin, total iron binding capacity were done by using Automatic Biochemistry Analyzer. Then data was analyzed by using Statistical Package for Social Science (SPSS) 20.0.

Results: Mean serum iron in Group A and Group B were 112.7 μg/dl and 87.6 μg/dl respectively. Mean serum ferritin concentration in Group A and Group B were 199.3 μg/dl and 107.0 μg/dl respectively. There was statistically significant increase in serum iron and serum ferritin concentrations in group A (p < 0.0001) compare to Group B (p < 0.0001). Both serum ferritin and serum iron levels show strong positive correlations with HbA1C ((r = 0.724, p < 0.001, r = 0.724, p < 0.001) and FPG ((r = 0.724, p < 0.001, r = 0.724, p < 0.001). The mean TIBC level was found 184 g/dl in Group A and 318.8 g/dl in Group B. TIBC levels were significantly lower in Group A than Group B and negative correlation was found between TIBC with HbA1c and FPG.

Conclusion: In comparison with healthy individuals, Type 2 DM patients had increased serum ferritin and serum iron levels and decreased TIBC with strong correlations of these parameters with glycemic control of diabetic’s patients. Thus, routine screening for iron status along with Glycemic control in diabetic patients might help preventing complications.

 Keyword: Diabetes Mellitus; Glycated Haemoglobin (HbA1c); Iron Status

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Citation

Citation: Nusrat Zerin., et al. “Iron Status in Type 2 Diabetes Mellitus Patients: A Tertiary Care Hospital Study”.Acta Scientific Medical Sciences 7.9 (2023): 120-129.

Copyright

Copyright: © 2023 Nusrat Zerin., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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