Abdulrahman Itopa Suleiman¹*, Elisha Urom², Audu Nasiru Opisa³, Ahmad Abdulrazak Itopa¹, Obadaki Idris Adeiza¹, Ummulhani Oyiza Obansa⁴, Ibrahim Salihu Amoto¹ and Onemola Kemi Rebecca¹

¹Department of Science Laboratory Technology, Kogi State Polytechnic, Lokoja, Nigeria
²Department of Physiology, University of Cross-River State, Calabar, Nigeria
³Department of Botany, Federal University, Lokoja, Nigeria

*Corresponding Author: Abdulrahman Itopa Suleiman, Department of Science Laboratory Technology, Kogi State Polytechnic, Lokoja, Nigeria.

Received: August 01, 2023; Published: August 14, 2023

Abstract

Pterocarpus mildbraedii leaf is among the commonly consumed leafy vegetables in Nigeria. Ethanol and aqueous extracts of the leaves had been found to exert anti-diabetic effect and nephroprotective potential in rats. This study was designed to investigate the possible nephroprotective effects of the ethanolic leaf extracts of this plant on the acetaminophen-induced Kidney damage in Wistar albino rats. Twenty adult albino Wister rats were purchased for this study. The rats were fed along-side with distilled water. The animals were grouped into five (5) groups: each group having four (4) animals as follows; Group A was given distilled water only (control group). Group B given 700 mg/kg of Paracetamol; Group C given 700 mg/kg of Paracetamol and treated with 54.8 mg/kg of plant extract. Group D was given 700 mg/kg of Paracetamol and treated with 27.4 mg/kg of plant extract. Group E given 700 mg/kg of Paracetamol and treated with 13.7 mg/kg of plant extract. Group A served as the control group, Group B, C, D, and E were administered with increasing dose of ethanolic extract of Pterocarpus mildbraedii. Histopathological evaluation of the kidney was also carried out. Furthermore, histopathological examination of the kidney samples revealed normal cellular architecture in both control and treated groups. These results suggest non-toxic effects of leaf extracts of P. mildbraedii on the kidney in rat. Hence, the plant can be considered safe for use as leafy vegetable, pharmaceutical and nutraceutical formulations.

 Keywords: Histopathology; Pharmaceutical Pterocarpus mildbraedii; Paracetamol; Nephroprotective

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Citation

Citation: Abdulrahman Itopa Suleiman., et al. “The Nephroprotective Potential of the Ethanolic Leaf Extract of Pterocarpus mildbraedii on the Histology of Acetaminophene-Induced Kidney Damage in Albino Wistar Rats”.Acta Scientific Medical Sciences 7.9 (2023): 93-97.

Copyright

Copyright: © 2023 Abdulrahman Itopa Suleiman., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.