Bacterial Prevalence in Sinonasal Aspirates of Chronic Rhinosinusitis Subtypes
Meghanadh Raja Koralla1, Madhavi Jangala1,2, Venkata Ramakrishna Jujjuvarapu1, Dinesh Dudekula1, Padmavathi Putta1, Santoshi Kumari Manche1,2, Pardhanandana P Reddy3 and Jyothy Akka2*
1MAA Research Foundation, Hyderabad, Telangana, India
2Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, Telangana, India
3Bhagawan Mahavir Medical Research Centre, Hyderabad, India
*Corresponding Author: Jyothy Akka, Emeritus Professor and Former Director, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, Telangana, India.
July 14, 2023; Published: August 08, 2023
Introduction: Bacteria and their products can act as disease modifiers in Chronic Rhinosinusitis (CRS) subtypes. However, studies related to the role of microbes in CRS subtypes are limited.
Objective: The purpose of the present retrospective study was to find and compare the prevalence of bacteria in sinonasal aspirates of CRS subtypes of allergy, asthma, nasal polyps and otitis media.
Patients and Methods: In the present study, microbial culture reports of 253 nasal aspirates and 449 sinus aspirates of CRS subjects who visited MAA ENT Hospitals, Hyderabad, South India from 2009 to 2019 were analyzed.
Results: Of the total CRS subjects 45.3% (n = 228) were affected by allergic rhinitis, 38.2% (27.3%) with nasal polyps, 26.6% (n = 134) with otitis media, 13.1% (n = 66%) with asthma. Bacterial positivity was seen in 48.4% of the cultures. Bacterial positivity increased significantly in sinus aspirates when compared to nasal secretions collected at first visit in CRS subjects with allergy (38.2% vs 22.8%), asthma (12.2% vs 9.4%), nasal polyp’s (grade >2) (17.6% vs 3.9%), otitis media (22.9% vs 14.1)) and hearing loss (30.6% vs 3.1). Staphylococcus aureus was found in 70% of sinus specimens of CRS subjects with asthma when compared to nonasthmatics (54.4%). Pseudomonas aeruginosa was mostly seen in nasal secretions at their first visit while klebsiella was seen in sinonasal aspirates of CRS subjects undergoing revision endoscopic surgery.
Conclusion: Our results find that bacterial prevalence varies with CRS subtypes and their severity. Comprehensive management of bacteria at an early stage might prevent the exacerbation of CRS and decrease its burden.
Keywords: Allergy; Asthma; Adenoids; Nasal Polyps; Otitis Media; Hearing Loss
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