Faraed D Salman*, Aya Jabbar Hussein, Manar Jabbar Hussein, Marwa Jabbar Hussein and Ahmed Jabbar Hussein

¹Professor in Dental Assistant Department Medical Technical Institute, Erbil Polytechnic University, Erbil, Iraq
²BSc Pharmacy (Iraq), MSc Cosmetic Science Student (USA/OH), MBA (USA/LA), USA
³PhD Iraqi Board Degree OBG, Masters in Aesthetic Gynecology (UK), Masters in STEM Cell and Regenerative Medicine, Iraq
⁴Mosul University – College of Medicine, FKBMS – Medical Oncology/Erbil-Iraq, ESMO/ASCO Certified, Iraq
⁵Baghdad University – Dentistry College, Baird British Academy Conservative Dentistry (Certificate), Iraq

*Corresponding Author: Faraed D Salman, Professor in Dental Assistant Department Medical Technical Institute, Erbil Polytechnic University, Erbil, Iraq.

Received: July 18, 2023; Published: August 03, 2023

Abstract

Background: The aims of this study are to reveal post covid-19 vaccine local and systematic side effects among Iraqi population group with the three COVID-19 vaccines available in Iraq, Pfizer – BioNTech (BNT 163b2) mRNA, AstraZeneca (chAd0x1 nCoV-19 vaccine) and SinoPharm (BBIBP-Cor Vaccine).

Materials and Methods: Across sectional study design was conducted (3064 online google forms) between October 2022 – January 2023 (4 months) among Iraqi population group of various educational background levels with 14 questions with their subdivisions pertaining 4 sections according to their most post-vaccine side effects via e-mail and social media platform, these 4 sections are: common local and systematic post vaccine side effects among Iraqi population group, most common side effects among female concerning MC irregularity, bleeding and pain, and post vaccine infection with covid-19 virus and its severity.

Results: Among 3064 people enrolled in the study, females comprised (57%), male (39%), (4%) of sample were missing (123). Majority of subjects belonged to age group 18-30 (71.6%), (59.9%) of total sample had no chronic disease and (74.9%) of total sample got vaccinated, Pfizer vaccine constituted the highest percentage (56.4%), following Sinopharm (17.3%) then AstraZeneca (12.4%). Majority of the population had gotten two shots of the available vaccines. Among local side effects pain at injection site constituted highest percentage (35%) followed by difficulty in moving vaccinated arm (30.5%), while among systemic side effects, joint pain constituted the highest percentage (26.7%), followed by fatigue and laziness (26.5%) and fever (11%) for more than 6 hours, while the other systemic effects were not present in most of the study sample and if it was present it was for 1 day like flu cough, shortness of breath, severe headache, chest heaviness, sore throat, GIT, UTI, tinnitus of the ear and skin allergic reactions. Concerning females, majority of them had no irregular MC, pain, or abnormal bleeding post vaccination. Concerning post vaccination with covid-19 virus, most of the sample (53.3%) were not infected with the virus, the percentage of those who got infected post first or 2^nd shot were very low (22.6%, 20.7%), the severity of infection was mild (21%) among those who got infected, with muscle ache, fever, flu, hospitalization cases were (23.9%) among infected cases for less than 7 days.

Conclusion: The study revealed satisfactory acceptance level for all types of vaccines (75%) available in Iraq, (39%) of participants were asymptomatic post vaccination, with mild to moderate symptoms in terms of severity which developed 24 hours post vaccination that requires home or medical symptomatic treatment and can be tolerated. So, these three types were found to be safe according to the observation of these symptoms, unusual adverse effects should be monitored carefully to determine whether they are related to vaccine or not.

 Keywords: Pfizer; AstraZeneca; Sinopharm Vaccine; Side Effects; Menstrual Cycle

References

1. Lurie N., et al. “Developing covid-19 vaccines at pandemic speed”. New England Journal of Medicine21 (2020): 1969-1973.
2. Caddy S. “Developing a vaccine for covid-19”. BMJ 369 (2020): m 1790.
3. World Health Organization. Status of covid-19 vaccines with WHO EUL/PQ evaluation process. Geneva, Switzerland (2021).
4. Voysey M., et al. “Safety and efficacy of the ChAdox 1n cov-19 vaccine (AZD 1222) against SARS-cov-2:an interim analysis of four randomised controlled trials in Brazil, South Africa and the UK”. Lancet 397 (2021): 99-111-10269.
5. Local reactions CDC. “Systemic reactions, adverse events and serious adverse events: pfizer-BioN Tech covid-19 vaccine”. 2021 (2021).
6. Zhang Y., et al. “Safety tolerability and immunogenicitu of an inactivated SARS-cov-2 vaccine in healthy adults aged 18-59 years: A randomised double blind, placebo-controlled, phase 1/2 clinical trial”. Lancet Infectious Disease2 (2021): 181-192.
7. World Health Organization. “WHO target product profiles for covid-19 vaccines”. Version 3-29 (2020).
8. Checcucci E., et al. “The vaccine Journey for covid-19: Acomprehensive systematic review of current clinical trials in humans”. Pauminerva Medicine1 (2022): 72-79.
9. Betty AL., et al. “Analysis of covid-19 vaccine type and adverse effects following vaccination”. JAMA Network Open 12 (2021): e 2140364.
10. Samar Amer. “Determinants of covid-19 vaccines adverse effects and effectiveness among vaccinated Arab population: A multinational descriptive study”. 3^rd Global webinar on public health (2022).
11. Hind B Almufty., et al. “Potential adverse effects of covid-19 vaccines among Iraqi population: A comparison between the three available vaccines in Iraq; A retrospective cross-sectional study”. Diabetes and Metabolic Syndrome: Clinical Research and Reviews 15 (2021): 102207.
12. Heba M Attash., et al. “Which type of the promising covid -19 vaccines produces minimal adverse effects? A retrospective cross-sectional study”. Vaccines 10 (2022): 186.
13. Rebar Y Abdullah., et al. “Galary: Covid-19 vaccines side effects among Iraqi people in Kurdistan Region, A cross-sectional study”. NSC Nursing Journal1 (2022): 1-22.
14. Lima-Martinez MM., et al. “Covid -19 and Diabetes: A bidirectional relationship”. Clínica e Investigación en Arteriosclerosis 3 (2021): 151-157.
15. Tadic M., et al. “Covid-19 Hypertension and cardiovascular diseases: Should we change the therapy?” Pharmacology Research 158 (2020): 104906.
16. Shields AM., et al. “Covid -19 in patients with primary and secondary immunodeficiency: The United Kingdom experience”. The Journal of Allergy and Clinical Immunology3 (2021): 870-5.el.
17. Leung JM., et al. “Covid-19 and COPD”. European Respiratory Journal2 (2021).
18. Liu Y., et al. “Covid-19 and autoimmune diseases”. Current Opinion in Rheumatology2 (2021): 155-162.
19. Hasanain F., et al. “Acceptance of covid-19 vaccine among General population in Iraq”. Iraqi National Journal of Medicine 1 (2021).
20. Fontanet A and Cauchemez S. “Covid-19 herd immunity: where are we?” Nature Reviews Immunology10 (2020): 583-584.
21. Wang J., et al. “Acceptance of covid-19 vaccination during the covid-19 pandemic in China”. Vaccines 3 (2022): 482.
22. Harpan H., et al. “Acceptance of a covid-19 vaccine in Southeast Asia: Across sectional study in Indonesia”. Frontiers in Public Health381 (2020).
23. Padhi BK., et al. “Determinants of covid-19 vaccine acceptance in Saudia Arabia: A web-based National Survey”. medRXiv (2020).
24. Fisher K., et al. “Attitudes toward a potential SARS-Cov-2 vaccine: A survey of U S adults”. Annals of Internal Medicines (2023).
25. Szmyd B., et al. “Medical students and SARS-Cov-2 vaccination: Attitude and Behaviors”. Vaccines 9 (2021): 128.
26. Szmyd B., et al. “Attitude and Behaviors toward SARS-Cov-2 vaccination among Health Care Workers: A cross-sectional study from Ppl and”. Vaccines 9 (2021): 218.
27. Abu-Hammad O., et al. “Side effects reported by Jordanian healthcare workers who received covid-19 vaccines”. Vaccines (Basel) 9 (2021): 557.
28. Al Khames Aga QA., et al. “Safety of covid-19 vaccines”. Journal of Medical Virology 93 (2021): 6588-94.
29. Centers for Diseases control and prevention. local reactions, systemic reactions, Adverse Events and serious adverse events: pfizer-BioNTech covid-19 Vaccine (2021).
30. Das L., et al. “Are we ready for covid-19 vaccines? A General side effects overview”. Journal of Current Medical Research and Opinion2 (2021).
31. Shahad M Khaleel., et al. “Adverse reactions of different covid -19 vaccines among health care professionals: A Qualitative study in Mosul, Iraq”.
32. El-Shitsny NA., et al. “Minor to moderate side effects of pfizer-Bio NTech covid-19 vaccine among Saudi Residents: A retrospective cross-sectional study”. International Journal of General Medicine 14 (2021): 1389-1401.
33. Alhamzi A., et al. “Evaluation of side effects associated with covid-19 vaccines in Saudia Arabia”. Vaccines 9 (2021): 674.
34. Elgendy MO., et al. “Covid-19 patients and contacted person awareness about home quarantine instructions”. International Journal of Clinical Practice 75 (2021): e 13810.
35. Subhashini Ganesan., et al. “Vaccine side effects following covid-19 vaccination among residents of the USE-An observational study”. Frontiers in Public Health 10 (2022): 876336.
36. Elnaem MH., et al. “Covid-19 vaccination attitudes, perceptions and side effects experiences in Malaysia: Do age, Gender and vaccine type matter?” Vaccines 9 (2021): 1156.
37. Lippi G., et al. “Mild adverse reactions after covid-19 vaccination: Updated analysis of Italian Medicines”. Agency Data (2021).
38. Miloslav Klugar., et al. “Side effects of mRNA-Based and viral vector-Based covid-19 vaccines among German Health care workers”. Biology Journal 10 (2021): 752.
39. Taher I., et al. “Side effects of pfizer-BioNTech covid-19 vaccine among Libyan young adults: Observational study”. Journal of Biosciences and Medicines 10 (2022): 33-45.
40. Alghamdi A., et al. “A cross sectional survey of side effects after covid-19 vaccination in Saudia Arabia: Male versus female outcomes”. Journal of Advanced Pharmacy Education and Research 11 (2021): 51-56.
41. Riad A., et al. “Prevalence of covid-19 vaccines side effects among HCW Czech Republic”. Journal of clinical Medicine 10 (2021): 1428.
42. Medicines And Health care products Regulatory Agency. Corona virus vaccine-weekly summary of yellow card reporting (2021).
43. Male V. “Effect of covid-19 vaccination on menstrual period in a retrospectively recruited cohort”. medRxiv (2021).
44. Edeleman A., et al. “Association between menstrual cycle length and corona virus disease 2019 (covid-19) vaccinations: A US cohort”. Obstetrics and Gynecology4 (2022): 481-489.
45. Von Woon E and Male V. “Effect of covid-19 vaccination on menstrual periods in a prospectively recruited cohort”. medXiv (2022).
46. Anjorin AA., et al. “Public Health surveillance for adverse events following covid-19 vaccination in Africa”. Vaccines (Basel)4 (2022): 456.
47. Dar-Odeh., et al. “Long term adverse events for three covid-19 vaccines as reported by vaccinated physicians and dentists, a study from Jordan and Saudia Arabia”. Human Vaccines and Immunotherapeutics1 (2022): 2039017.
48. Cheng Y., et al. “Self reported adverse effects among Chinese HCWS immunized with covid-19 vaccines composed of in activated SARS-Cov-2”. Human Vaccines and Immunotherapeutics 14 (2022): 1-7.
49. Alghamdi AN., et al. “BNT162b2&chAdox1 SARS-Cov-2 post vaccination side effects among Saudi Vaccinees”. Frontiers in Medicine (Lausanne)8 (2022): 760947.
50. Raghad AH., et al. “Effect of covid-18 on menstrual cycle”. Neuro Quantology10 (2022): 28-38.
51. Takmaz T., et al. “The impact of covid-19 related mental health issues on menstrual cycle characteristics of female health care providers”. Journal of obstetrics and Gyneacology Research9 (2021): 3241-3249.
52. Kwak Y., et al. “Prevalence of irregular menstruation according to socioeconomic status: A population-based nationwide cross-sectional study”. Plos One3 (2019): eo214071.
53. Morsi A., et al. “The association between covid-19 pfizer vaccine and the reported post-vaccination menstrual changes in citizens and resident women in KSA: Results from Riyadh survey study”. The Egyptian Journal of Hospital Medicine1 (2022): 1442-1448.
54. Muhaidat N., et al. “Menstrual symptoms for covid-19 vaccine: A cross-sectional investigation in the MENA region”. International Journal of Women's Health 14 (2021): 395-404.
55. Logana AS., et al. “Evaluation of menstrual irregularities after covid-19 vaccination: results of the MECOVAC survey”. Open Medicine (Wars)1 (2022): 475-484.
56. Lee KMN., et al. “Investigation trends in these who experiences menstrual bleeding changes after SARS-Cov-2-vaccination”. medRxiv (2021).
57. Trogstd L., et al. “Increased occurrence of menstrual disturbances in 18-to-39 year-old women after covid-19 vaccination”. SSRN (2022).
58. Hatmal M., et al. “Side effects and perceptions following covid-19 vaccination in Jordan. A randomized cross-sectional study implementing machine learning for predicting severity of side effects”. Vaccines 9 (2021): 556.

Citation

Citation: Faraed D Salman., et al. “Post COVID-19 Vaccine Side Effects Among Iraqi Population Group: A National Cross-Sectional Retrospective Study”.Acta Scientific Medical Sciences 7.9 (2023): 03-17.

Copyright

Copyright: © 2023 Faraed D Salman., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.