Kosaev JV¹*, Hasanov IA², Abushov NS¹, Taghi-zade GT¹, Sadikhov FQ¹, Ibrahimova GR¹ and Guliyev RA¹

¹Scientific Center of Surgery, M.A. Topchubasheva, Baku, Azerbaijan
²Azerbaijan State Institute for Advanced Training of Doctors Named After A. Aliyev, Baku, Azerbaijan

*Corresponding Author: Kosaev JV, Scientific Center of Surgery, M.A. Topchubasheva, Baku, Azerbaijan.

Received: July 17, 2023; Published: July 20, 2023

Abstract

Objective: To study immunocorrection in patients with critical lower limb ischemia (CLLI) in revascularizing osteotrepanation with intramedullary laser irradiation (ROT with IMLI) using intravenous laser irradiation of blood (ILIB) and cytokine therapy (CT) in the perioperative period.

Material and Methods: A prospective controlled clinical trial was conducted in 65 patients with CLLI against the background of distal steno-occlusion of the arteries who underwent indirect revascularization surgery. In the perioperative period, 34 patients underwent standard treatment (control group), 31 patients with ROT with IMLI underwent standard treatment + ILIB + CT (main group). The parameters of humoral immunity (CD19-lymphocytes; Ig A, Ig M, IgG. The dynamics of CD25-positive, interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α)-positive cells of peripheral blood were also studied. The studied indicators of immune status were compared with identical parameters of 48 practically healthy individuals ("reference group").

Results: Upon admission to the clinic in patients with CLLI with distal steno-occlusion, abrupt changes in humoral immunity and CD25-positive, interleukin-6 (IL-6), tumor necrosis factor -α (TNF-α)-positive peripheral blood cells were revealed. Inclusion of ILIB and CT in the complex of therapeutic measures in the perioperative period during the operation of ROT with IMLI. With indirect revascularization, it led to a significant (p < 0.05) leveling of immune parameters. Correction of immunological parameters significantly (p < 0.01-0.001) depends on the use of ILIB and CT in the perioperative period during the operation of ROT with IMLI Inclusion of ILIB and CT in the complex of therapeutic measures in the perioperative period during the operation of ROT with IMLI. With indirect revascularization, it led to a significant (p < 0.05) leveling of immune parameters. Correction of immunological parameters significantly (p < 0.01-0.001) depends on the use of ILIB and CT in the perioperative period during the operation of ROT with IMLI with a moderate (r = 0.5-0.6) correlation.

Conclusion: The use of ILIB and CT together with standard treatment in the perioperative period in ROT with IMLI significantly corrects the immunological parameters in patients with CLLI with distal steno-occlusion of the arteries and the dynamics of these indicators can be used as an objective criterion for assessing the effectiveness of the therapy.

 Keywords: Arterial Occlusion; Critical Ischemia of the Lower Extremities; Indirect Revascularization; Intravenous Laser Irradiation of Blood; Cytokine Therapy; Immunocorrection

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Citation

Citation: Kosaev JV., et al. “Immunocorrection in Patients with Critical Ischemia of the Lower Extremities During Revascularizing Osteotrepanation with Intramedullary Laser Irradiation with the Use of Intravenous Laser Irradiation and Cytokine Therapy in the Perioperative Period”.Acta Scientific Medical Sciences 7.8 (2023): 164-170.

Copyright

Copyright: © 2023 Kosaev JV., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.