Hugh James Freeman*
Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada
*Corresponding Author: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.
Received: July 03, 2023; Published: July 17, 2023
Brain white-matter lesions may be detected late in the clinical course of different disorders thought to have an autoimmune pathogenesis, particularly in the pediatric population. Here, a 42 year old male with diarrhea and weight loss was discovered to have adult onset celiac disease. After institution of a gluten-free diet, he responded with resolution of his diarrhea, weight gain and histological improvement. Over a decade later, he was observed to have incidental white-matter lesions in his central nervous system detected with MRI and thought to have resulted from microvascular changes or inflammatory demyelination. This report describes an adult with brain white-matter lesions in well-established celiac disease and failure of a long-term gluten-free diet to prevent their development.
Keywords: Celiac Disease; Gluten-free Diet; Brain White-Matter Lesions; Demyelination; Vascular Disease; Autoimmune Disease
Citation: Hugh James Freeman. “White-Matter Lesions in the Central Nervous System in Biopsy-Defined Adult Celiac Disease”.Acta Scientific Medical Sciences 7.8 (2023): 115-117.
Copyright: © 2023 Hugh James Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.