Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Report Volume 7 Issue 8

White-Matter Lesions in the Central Nervous System in Biopsy-Defined Adult Celiac Disease

Hugh James Freeman*

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

*Corresponding Author: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.

Received: July 03, 2023; Published: July 17, 2023

Abstract

Brain white-matter lesions may be detected late in the clinical course of different disorders thought to have an autoimmune pathogenesis, particularly in the pediatric population. Here, a 42 year old male with diarrhea and weight loss was discovered to have adult onset celiac disease. After institution of a gluten-free diet, he responded with resolution of his diarrhea, weight gain and histological improvement. Over a decade later, he was observed to have incidental white-matter lesions in his central nervous system detected with MRI and thought to have resulted from microvascular changes or inflammatory demyelination. This report describes an adult with brain white-matter lesions in well-established celiac disease and failure of a long-term gluten-free diet to prevent their development.

 Keywords: Celiac Disease; Gluten-free Diet; Brain White-Matter Lesions; Demyelination; Vascular Disease; Autoimmune Disease

References

  1. Freeman HJ. “Neurological disorders in adult celiac disease”. Canadian Journal of Gastroenterology 22 (2008): 909-911.
  2. Therrien A., et al. “Celiac disease: extra intestinal manifestations and associated conditions”. Journal of Clinical Gastroenterology 54 (2020): 8-21.
  3. Giuffre M., et al. “Celiac disease and neurological manifestations: from gluten to neuroinflammation”. International Journal of Molecular Sciences 23 (2022): 15564.
  4. Kieslich M., et al. “Brain white-matter lesions in celiac disease: a prospective study of 75 diet-treated patients”. Pediatrics 108 (2001): E21.
  5. Freeman HJ. “Mucosal recovery and mucosal healing in biopsy defined adult celiac disease”. International Journal of Celiac Disease 5 (2017): 40-42.
  6. Turner MR., et al. “Autoimmune disease preceding amyotrophic lateral sclerosis”. Neurology 81 (2013): 1222-1225.
  7. Brown KJ., et al. “White matter lesions suggestive of amyotrophic lateral sclerosis attributed to celiac disease”. AJNR American Journal of Neuroradiology 31 (2010): 880-881.
  8. Turner M.R., et al. “A case of celiac disease mimicking amyotrophic lateral sclerosis”. Nature Clinical Practice Neurology 3 (2007): 581-584.
  9. Ham H., et al. “A case of celiac disease with neurologic manifestations misdiagnosed as amyotrophic lateral sclerosis”. Intestinal Research 15 (2017): 540-542.
  10. Ludvigsson JF., et al. “No association between biopsy-verified celiac disease and subsequent amyotrophic lateral sclerosis—a population based cohort study”. European Journal of Neurology 21 (2014): 976-982.
  11. Visser AE., et al. “No association between gluten sensitivity and amyotrophic lateral sclerosis”. Journal of Neurology 264 (2017): 694-700.

Citation

Citation: Hugh James Freeman. “White-Matter Lesions in the Central Nervous System in Biopsy-Defined Adult Celiac Disease”.Acta Scientific Medical Sciences 7.8 (2023): 115-117.

Copyright

Copyright: © 2023 Hugh James Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In





News and Events


Contact US