Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 8

Usefulness of the Determination of Interleukin-6 (IL-6) in Amniotic Fluid in Women at Risk of Preterm Birth

Clemente-Tomás CP1* and Moreno-Sanz L2

1Department of Gynecology and Obstetrics, Doctor Peset University Hospital, Valencia, Spain
2Department of Gynecology and Obstetrics, Obispo Polanco Hospital, Teruel, Spain

*Corresponding Author: Clemente-Tomás CP, Department of Gynecology and Obstetrics, Doctor Peset University Hospital, Valencia, Spain.

Received: June 16, 2023; Published: July 10, 2023

Abstract

Objective: We compare the levels of IL-6 in the AF of pregnant women with cervical shortening versus women with normal cervical length subjected to amniocentesis for other prenatal reasons (fetal malformations or high risk in prenatal screening), with the aim of establishing a cut-off point to facilitate prediction of the outcome of pregnancy.

Material and Methods: A descriptive case-control study design was applied to subjects (n=40) with available information on the results of amniotic fluid IL-6 levels. We examined perinatal outcomes.

The study comprised 40 women: 6 cases with cervical shortening (15%) and 34 controls with normal cervical length throughout pregnancy (85%). The mean IL-6 concentration among the cases was 758.83 pg/ml versus 1291.53 pg/ml in the control group, which moreover registered the highest concentration (16,383 pg/ml). The mean gestational age at delivery was 33 ± 6 weeks among the cases and 40 ± 3 weeks in the control group.

Results: Our results do not indicate that the determination of IL-6 in AF is useful for the diagnosis of subclinical chorioamnionitis as a possible cause of cervical shortening and consequent PB, since the controls with normal cervical length and full-term delivery showed higher concentrations than the women with cervical shortening.

Conclusion: Our findings do not suggest the determination of IL-6 in AF to be useful for the early diagnosis of such disorders and thus for the prevention of PB.

 Keywords: Preterm Birth; Interleukin-6; Amniotic Fluid; Chorioamnionitis; Cervical Length; Amniocentesis

References

  1. Beck S., et al. “The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity”. Bulletin of the World Health Organization 1 (2010): 31-38.
  2. Muglia L and Katz M. “The enigma of spontaneous pre-term birth”. The New England Journal of Medicine 362 (2010): 529-535.
  3. Huertas E. “Preterm birth, causes and preventive measures”. Revista Peruana de Ginecología y Obstetricia3 (2018): 399-404.
  4. Reyna E., et al. “Cervicovaginal interleukin-6 in the prediction of preterm delivery”. Revista Peruana de Ginecología y Obstetricia2 (2016): 175-181.
  5. Hasbun H J and Hasbun NA. “Infection and preterm birth: Epidemiological and biochemical linkage”. Revista Chilena De Infectología1 (2000): 7-17.
  6. Marcelo L and González V E. “Pro-inflammatory cytokines related to the subclinical chorioamnionitis and the preterm labor”. Revista Cubana de Obstetricia y Ginecología4 (2011): 562-576.
  7. Ferrer R., et al. “Clinical and histological chorioamnionitis”. Bibliographic revision. Multimed 18.1 (2014): 180-190.

Citation

Citation: Clemente-Tomás CP and Moreno-Sanz L. “Usefulness of the Determination of Interleukin-6 (IL-6) in Amniotic Fluid in Women at Risk of Preterm Birth”.Acta Scientific Medical Sciences 7.8 (2023): 84-86.

Copyright

Copyright: © 2023 Clemente-Tomás CP and Moreno-Sanz L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

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