Hugh J Freeman*

Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada

*Corresponding Author: Hugh J Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC, Canada.

Received: May 31, 2023; Published: June 12, 2023

Abstract

Biologically active monoclonal antibodies functioning as checkpoint inhibitors have been used in cancer treatment with improved overall patient survival. Infusions may be complicated by development of diarrhea, sometimes severe. In some, an immune-mediated enterocolitis occurs, sometimes difficult to treat, occasionally with a fatal outcome. Less well appreciated are other less commonly detected forms of colitis, such as collagenous colitis, as well as alterations in the small bowel alone, including a distinctive sprue-like intestinal disease. These may all be entirely independent inflammatory processes. Together, these likely represent different phenotypic expressions of treatment toxicity in the intestinal tract following management of cancer with infused checkpoint inhibitor monoclonal antibodies.

Celiac Disease; Sprue-like Intestinal Disease; Enteritis; Enterocolitis; Checkpoint Inhibitors; Advanced Malignancy; Metastatic Melanoma

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Citation

Citation: Hugh J Freeman. “Monoclonal Antibodies for Checkpoint Inhibitors and Sprue-Like Intestinal Disease”.Acta Scientific Medical Sciences 7.7 (2023): 36-39.

Copyright

Copyright: © 2023 Hugh J Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.