AV Troitsky¹, LA Cherdantseva³, TN Bystrova¹, EG Novikova^1,2*, HU Ukah¹, OV Grishin¹ and EA Lyadov⁴

¹Federal Medical Research Centre of Fundamental and Translational Medicine, Novosibirsk, Russia
²Regional Medical and Diagnostic Centre Ltd., Novosibirsk, Russia
³Novosibirsk Research Institute of Traumatology and Orthopedics n.a. Ya.L. Tsivyan, Novosibirsk, Russia
⁴St. Petersburg Tuberculosis Sanatorium “Pinery”, Saint Petersburg, Russia

*Corresponding Author: EG Novikova, Federal Medical Research Centre of Fundamental and Translational Medicine, Novosibirsk, Russia.

Received: April 05, 2023; Published: April 24, 2023

Abstract

Rationale for the Study: The relevance of the study is due to the large number of fibrous complications in viral interstitial pneumonia in COVID-19 patients in where …. Pulmonary fibrosis develops most often.

Objective of the Study: Title of the study to evaluate Role of Oxidized Dextran In Prevention and Control of Viral Pneumonia and Pulmonary Fibrosis

Specifically the therapeutic efficacy of inhalation administration of 2% oxidized dextran solution in an in vivo model that mimics interstitial pneumonia in COVID-19.

Materials and Methods: The studies were performed on mice of the ACR line. And interstitial pneumonia in mice was caused by intranasal administration of the lipopolysaccharide Escherichia coli (LPS)." After intranasal administration of LPS to mice and legalization of a 2% solution of oxidized dextran and a control solution (physiological solution), they were carried out using an ultrasonic inhaler. A day later, the animals were slaughtered and prepared standard histological sections of lung tissue, followed by morphometric evaluation of the results.

Results with Data: inhalation administration of a 2% solution of oxidized dextran can almost 2 times reduce all morphological manifestations of LPS induced pneumonia by morphometric indicators: histe density of vessels with signs of hemocirculatory disorders, numerical density of thrombosed vessels, percentage of thrombosed vessels, volumetric density of hemorrhages, volumetric density of hemorrhages atelectasis, and volumetric density of cellular inflammatory infiltrate).

Conclusion: And the administration of oxidized dextran solutions may be a very promising method of preventing pulmonary fibrosis in COVID-19.

 Keywords: Oxidized Dextran; Pneumonia; Pulmonary Fibrosis; Prevention and Control; COVID 19

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Citation

Citation: EG Novikova., et al. “Role of Oxidized Dextran in Prevention and Control of Viral Pneumonia and Pulmonary Fibrosis”.Acta Scientific Medical Sciences 7.5 (2023): 164-172.

Copyright

Copyright: © 2023 EG Novikova., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.