Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 5

Evaluation of Advanced Oxidation Protein Products in Sickle Cell Disease in Brazzaville

Madzou Moukassa VBF1,2,5*, Onanga Koumou1,2, Malanda Félix1,2, Loumingou JR1,2, Mahoungou Gael1,2, Simo Loukdom Josué4,2, Mokondjimobé Etienne1, Makélé Mabika Bleine1, Malanda Kiminou Privat1,2, Massala Péya Jethro1 and Elira Dokékias Alexis1,2

1Faculty of Health Sciences, Congo
2Brazzaville University Hospital Center, Congo
3Sickle Cell Disease National Reference Center, Congo
4University of Mountains, Cameroon
5General Office and Logistics Laboratory, Congo

*Corresponding Author: Madzou Moukassa VBF, Hospital Biologist, Biochemistry and Molecular Biology Specialty, Faculty of Health Sciences, Congo.

Received: January 09, 2023; Published: April 12, 2023

Abstract

The main objective of this study was to evaluate advanced oxidation protein products (AOPPs) in sickle cell nephropathy. This was a case-control study of 70 patients. They were subdivided into 2 groups: The group of 30 patients with nephropathy called the case group and the control group consisting of 40 people, subdivided into 2 groups: the T1 group with 20 SS patients without nephropathy and the T2 group with 20 AA patients without nephropathy. There was a small increase in the AOPPs in the group of patients with nephropathy compared with the control group (P = 0.053). Renal biomarkers showed no statistically significant difference (P > 0.05). No correlation was found between AOPPs and renal clearance and between AOPPs and microalbuminuria (r = 0,07; r = 0,043 and P > 0,05). The small sample size of this study does not allow the necessary conclusions to be drawn regarding the effects of AOPPs in sickle cell disease in the Congolese population, especially as this is a preliminary study.

 Keywords: Sickle Cell Disease; Nephropathy; Advanced Oxidation Protein Products (Aopp)

References

  • Pour TM., et al. Thèse de Doctorat de l ’ Université Paris XII Biochimie, Biologie Cellulaire et Moléculaire Modélisation Mathématique et Simulation Numérique de la Polymérisation de l’ Hémoglobine Drépanocytaire. (2008).
  • https://www.theses.fr/2015ANTI0045
  • Rifkind JM and Nagababu E. “Hemoglobin redox reactions and red blood cell aging”. Antioxidants Redox Signal17 (2013): 2274-2283.
  • Berger MM and Chioléro RL. “Apport d’antioxydants en réanimation: Pourquoi, lesquels, avec quels objectifs?” Reanim Urgences6 (2001): 527-534.
  • https://www.urofrance.org/base-bibliographique/les-complications-renales-de-la-drepanocytose
  • Sciences UDES, Odontostomatologie D, U- DDEPDUCH, Toure G, Jury MDU. THESE. (2021).
  • Cao W., et al. “AOPPs and the progression of kidney disease”. Kidney International1 (2014): 102-106.
  • Les C., et al. “Mali medical”. Transfusion 4 (2011): 12-15.
  • Abdu A., et al. “Proteinuria among adult sickle cell anemia patients in Nigeria”. Annals of African Medicine 1 (2011): 34-37.
  • Badiou S. abc. 67.2 (2009): 153-158.
  • Bourquin V and Giovannini M. “Protéinurie, 2e partie. Approche diagnostique et prise en charge. Signification dune microalbuminurie”. Forum Médical Suisse Swiss Med Forum36 (2007).
  • Witko-sarsat V., et al. “Advanced Oxidation Protein Products as Novel Mediators of Inflammation and Monocyte Activation in Chronic Renal Failure”. 1.2 (2021).
  • Citation

    Citation: Madzou Moukassa VBF., et al. “Evaluation of Advanced Oxidation Protein Products in Sickle Cell Disease in Brazzaville”.Acta Scientific Medical Sciences 7.5 (2023): 91-95.

    Copyright

    Copyright: © 2023 Madzou Moukassa VBF., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




    Metrics

    Acceptance rate30%
    Acceptance to publication20-30 days
    Impact Factor1.403

    Indexed In





    News and Events


    • Certification for Review
      Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
    • Submission Timeline for Upcoming Issue
      The last date for submission of articles for regular Issues is June 25, 2024.
    • Publication Certificate
      Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
    • Best Article of the Issue
      The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
    • Welcoming Article Submission
      Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

    Contact US