Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 7 Issue 4

Toxicological Effects of Carbendazim: A Review

Muhammad Hashim1*, Atef M Al-Attar1,2 and Isam M Abu Zeid1,2

1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
2Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author: Muhammad Hashim, Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Received: March 06, 2023; Published: March 31, 2023

Abstract

Pesticides are usually inorganic substances used in agriculture to control various types of crops to kill insects and pests, weeds, rodents, fungi, and unwanted microorganisms. The biggest challenge today is that they are not limited to the agrochemical sector but are also used in households to kill mosquitoes, eliminate fungal and microbial activities that contaminate kitchens and food. One of these chemicals used as a fungicide to prevent fungal attack is carbendazim (CBZ) or methyl-1H-benzimidazol-2-yl-carbamate (MBC), one of the many chemicals used to protect crops from fungal attack. Several studies have been conducted to investigate the toxicological effects of CBZ on organismal health, environmental contamination, detection, and degradation. These studies have evaluated biochemical and histopathological changes in the liver, kidney, and testes, as well as concerns related to dermal, oral, and respiratory exposure to lethal and sublethal doses of CBZ. The current challenge is to develop less hazardous or organic alternatives to protect the environment and human health. This review highlights the hazards associated with CBZ and discusses potential alternative organic chemotherapeutics that are health friendly to the environment and organismic health.

 Keywords: CBZ, health risks, environmental toxicity, degradation, organic chemotherapeutics.

References

  1. Cuppen JG., et al. “Impact of the fungicide carbendazim in freshwater microcosms. I. Water quality, breakdown of particulate organic matter and responses of macroinvertebrates”. Aquatic toxicology2-3 (2000): 233-250.
  2. Hashim M. “Pesticides and drinking water”. Journal of Advanced Botany Zoology1 (2015): 1-5.
  3. Moffit JS., et al. “Dose-dependent effects of sertoli cell toxicants 2, 5-hexanedione, carbendazim, and mono- (2-ethylhexyl) phthalate in adult rat testis”. Toxicologic pathology5 (2007): 719-727.
  4. Goyal K., et al. “Double edge sword behavior of carbendazim: a potent fungicide with anticancer therapeutic properties”. Anti-Cancer Agents in Medicinal Chemistry1 (2018): 38-45.
  5. Ribeiro F., et al. “Is ultraviolet radiation a synergistic stressor in combined exposures? The case study of Daphnia magna exposure to UV and carbendazim”. Aquatic Toxicology1-2 (2011): 114-122.
  6. JanakiDevi V., et al. “A study of proteotoxicity and genotoxicity induced by the pesticide and fungicide on marine invertebrate (Donax faba)”. Chemosphere3 (2013): 1158-1166.
  7. Shi T., et al. “Effects of field-realistic concentrations of carbendazim on survival and physiology in forager honey bees (Hymenoptera: Apidae)”. Journal of Insect Science4 (2018): 6.
  8. Zari TA., et al. “Therapeutic effects of olive leaves extract on rats treated with a sublethal concentration of carbendazim”. European Review for Medical and Pharmacological Sciences 4 (2011): 413-426.
  9. Li J., et al. “The effects of carbendazim on acute toxicity, development, and reproduction in Caenorhabditis elegans”. Journal of Food Quality 2020 (2020): 1-6.
  10. Gray Jr LE., et al. “Carbendazim-induced alterations of reproductive development and function in the rat and hamster”. Fundamental Applied Toxicolo2 (1990): 281-297.
  11. Prashantkumar W., et al. “Testicular damage after chronic exposure to carbendazim in male goats”. Toxicological Environmental Chemistry Letters7 (2012): 1433-1442.
  12. Sitarek KJT. “Embryolethal and teratogenic effects of carbendazim in rats”. Teratogenesis, Carcinogenesis, Mutagenesis5 (2001): 335-340.
  13. Organization WH. The WHO recommended classification of pesticides by hazard and guidelines to classification 2019. 2020: World Health Organization.
  14. Farag A., et al. “Developmental toxicity of fungicide carbendazim in female mice”. Birth Defects Research Part B: Developmental Reproductive Toxicology2 (2011): 122-130.
  15. Yu G., et al. “Effects of subchronic exposure to carbendazim on spermatogenesis and fertility in male rats”. Toxicology Industrial Health1 (2009): 41-47.
  16. Mirzaei A., et al. “Protecting impact of Jaft against carbendazim induced biochemical changes in male Wistar rats”. Journal of Medicine Life 8 (2015).
  17. Jacobsen H., et al. “Repeated dose 28-day oral toxicity study in Wistar rats with a mixture of five pesticides often found as residues in food: alphacypermethrin, bromopropylate, carbendazim, chlorpyrifos and mancozeb”. Food Chemical Toxicology8 (2004): 1269-1277.
  18. Muthuviveganandavel V., et al. “Toxic effects of carbendazim at low dose levels in male rats”. The Journal of Toxicological Sciences1 (2008): 25-30.
  19. Selmanoğlu G., et al. “Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats”. Human Experimental Toxicology12 (2001): 625-630.
  20. Pacheco S.E., et al. “Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat”. (2012).
  21. Salihu M., et al. “6-Gingerol-rich fraction from Zingiber officinale prevents hematotoxicity and oxidative damage in kidney and liver of rats exposed to carbendazim”. Journal of Dietary Supplements4 (2016): 433-448.
  22. Adedara IA., et al. “Induction of oxidative stress in liver and kidney of rats exposed to Nigerian bonny light crude oil”. Environmental toxicology6 (2012): 372-379.
  23. Kerem M., et al. “Effects of acute fenthion toxicity on liver and kidney function and histology in rats”. Turkish Journal of Medical Sciences5 (2007): 281-288.
  24. Rama EM., et al. “Reproductive and possible hormonal effects of carbendazim”. Regulatory Toxicology Pharmacology3 (2014): 476-486.
  25. Rui Q., et al. “Biosafety assessment of titanium dioxide nanoparticles in acutely exposed nematode Caenorhabditis elegans with mutations of genes required for oxidative stress or stress response”. Chemosphere10 (2013): 2289-2296.
  26. Cybulski J., et al. “Mutagenność 2-benzimidazolokarbaminianu metylu (karbendazymu) w testach in vivo i in vitro. Roczniki Państwowego Zakładu Higieny4 (1983).
  27. Bentley KS., et al. “Evaluation of thresholds for benomyl-and carbendazim-induced aneuploidy in cultured human lymphocytes using fluorescence in situ hybridization”. Mutation Research/Genetic Toxicology Environmental Mutagenesis 1 (2000): 41-51.
  28. Vanhauwaert A., et al. “The in vivo gut micronucleus test detects clastogens and aneugens given by gavage”. Mutagenesis1 (2001): 39-50.
  29. Winder B., et al. “The role of GTP binding and microtubule-associated proteins in the inhibition of microtubule assembly by carbendazim”. Toxicological Sciences1 (2001): 138-146.
  30. Davidse LCJArop. “Benzimidazole fungicides: mechanism of action and biological impact”. Annual Review of Phytopathology1 (1986): 43-65.
  31. Đikić D., et al. “Carbendazim combined with imazalil or cypermethrin potentiate DNA damage in hepatocytes of mice”. Human Experimental Toxicology5 (2012): 492-505.
  32. Ilyushina NJRJoG. “Cytogenetic effects of carbendazim on mouse bone marrow cells”. Russian Journal of Genetics10 (2020): 1193-1202.
  33. Kiss A., et al. “Photostability and photodegradation pathways of distinctive pesticides”. Journal of Environmental Quality1 (2009): 157-163.
  34. Lewandowska A., et al. “Carbendazim Residues in the Soil and Their Bioavailability to Plants in Four Successive Harvests”. Polish Journal of Environmental Studies4 (2010).
  35. Lim SJ., et al. “Quantitative analysis of matrine and oxymatrine in Sophora flavescens extract and its biopesticides by UPLC”. Journal of Agricultural Chemistry Environmental Science02 (2014): 64.
  36. García PC., et al. “Is the application of carbendazim harmful to healthy plants? Evidence of weak phytotoxicity in tobacco”. Journal of Agricultural Food Chemistry2 (2002): 279-283.
  37. Li YH., et al. “Transfer assessment of carbendazim residues from rape flowers to apicultural products”. Journal of Analytical Methods in Chemistry 2017 (2017).
  38. Xu X., et al. “Carbendazim residues in vegetables in China between 2014 and 2016 and a chronic carbendazim exposure risk assessment”. Food Control (2018): 20-25.
  39. Yildirim N., et al. “Effects of carbendazim on dna damage and retrotransposon polymorphism in Zea mays”. Environmental Engineering Management Journal8 (2020).
  40. Sakr SA., et al. “Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract”. Toxicology Industrial Health3 (2014): 259-267.
  41. Lamfon HA. “Effect of fenugreek seed extract on carbendazim-inhibited spermatogenesis in albino rats”. Journal of Applied Pharmaceutical Science Issue (2012): 09-13.
  42. Mahboub FA., et al. “Protective effect of Gingo biloba extract on carbendazim-induced hepatotoxicity in albino rats”. (2013).
  43. Hashem MA., et al. “Assessment of protective potential of Nigella sativa oil against carbendazim-and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity”. Environmental Science Pollution Research (2018): 1270-1282.
  44. Abou Zaid O., et al. “Assessment of protective potential of Quercitin against carbendazim-induced testicular damage in male rats”. Benha Veterinary Medical Journal2 (2018): 305-320.
  45. Alghamdi SA. “Effect of Nigella sativa and Foeniculum vulgare seeds extracts on male mice exposed to carbendazim”. Saudi journal of biological sciences10 (2020): 2521-2530.
  46. Kiran KU. “Toxicopathological Studies on Carbendazim and its Amelioration with Vitamin E in Female Chicken”. (2022).
  47. Lalhriatpuia P., et al. “Protective effect of vitamin c on carbendazim induced hemato-biochemical alterations in male rats”. Journal of Veterinary Pharmacology Toxicology1 (2021): 70-76.
  48. Abdel-Rahman GN., et al. “Control of carbendazim toxicity using banana peel powder in rats”. Biotechnology Reports (2022): e00773.

Citation

Citation: Muhammad Hashim., et al. “Toxicological Effects of Carbendazim: A Review”.Acta Scientific Medical Sciences 7.4 (2023): 218-225.

Copyright

Copyright: © 2023 Muhammad Hashim., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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