Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 7 Issue 4

Nutrition Profile of Women with Functional Upper Gastrointestinal Disorders

Giga Sordia1*, Gela Sulaberidze1, Maia Okujava2, Marina Tughushi1 and Konstantine Liluashvili1

1Department of General Internal Medicine, Tbilisi State Medical University, Georgia
2Department of Medical Pharmacology, Tbilisi State Medical University, Georgia

*Corresponding Author: Giga Sordia, Department of General Internal Medicine, Tbilisi State Medical University, Georgia.

Received: March 14, 2023; Published: March 29, 2023


The dietary profile is considered an important trigger causing symptoms of the functional upper gastrointestinal disorders,thus, the optimization of food intake is an important element in the treatment of non-erosive gastroesophageal reflux disease (NERD) and functional dyspepsia(FD).The cohort of 164 patients (mean age 31.4 ± 7.7 years) with NERD (84 patients, 51.2%) and FD (80 patients, 48.8%) was studded to evaluatethe possible links between dietary patterns and upper gastrointestinal functional disorders. The data obtained from one-month nutritional history questionnaires were used to quantify the usual intake of essential nutrients, including dietary fiber, which make up the energy balance. The gained data were reviewed by age of patients and forms of the disease. Comparisons were made between subgroups of patients, and regression models were analyzed. In the entire group of patients involved in the study, as well as ingroups divided by age and symptoms of functional gastrointestinal disorder, an absolute deficiency of intake of dietary fiber was revealed. Dietary fiber was significantly less consumed among patients aged <35 years compared to those aged ≥35 years (19.6 ± 9.3 g/day vs. 27.8 ± 7.9 g/day, p < 0.0001). The results of the regression analysis of the nutrients consumed revealed that in all study groups carbohydrate intake was a significant predictor of dietary fiber intake (coefficient of probability from 6.60 ± 1.27 to 9.65 ± 0.58). Conversely, the predictability of fiber consumption in relation to carbohydrates is very low (coefficient of probability - from 0.06 ± 0.01 to 0.08 ± 0.01). This relationship indicates that fiber is consumed from food forms that are high in simple carbohydrates and low in complex carbohydrates, including fiber. Deficiency of energy obtained from food was detected in 24.4% of patients, excess energy intake - in 43.3%, and recommended intake - in 32.3%. Assessment of consumption of macronutrientsin groups with different energy profiles revealed a relative deficiency of carbohydrate and protein intake and a relative excess of fat intake. In patients with NERD and FD intake of total fiber, as well as fiber from bread and wheat products, is significantly insufficient and it is consumed mainly from products with low fiber content.

Keywords: Non-erosive Gastroesophageal Reflux Disease; Functional Dyspepsia; Nutrients; Carbohydrates; Protein; Fat; Dietary Fiber; Energy Balance


  1. Sperber AD., et al. “Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study”. Gastroenterology1 (2021): 99-114.e3.
  2. Aziz I., et al. “Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: a cross-sectional population-based study”. Lancet Gastroenterology and Hepatology 3 (2018): 252-262.
  3. Palsson OS., et al. “Rome IV diagnostic questionnaires and tables for investigators and clinicians”. Gastroenterology 6 (2016): 1481-1491.
  4. Palsson OS., et al. “Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom”. Gastroenterology 158 (2020): 1262-1273.e3.
  5. Drossman DA., et al. “Neuromodulators for Functional Gastrointestinal Disorders (Disorders of Gut-Brain Interaction): A Rome Foundation Working Team Report”. Gastroenterology4 (2018): 1140-1171.e1.
  6. Chirila I., et al. “The role of diet in the overlap between gastroesophageal reflux disease and functional dyspepsia”. Turkish Journal of Gastroenterology 27 (2016): 73-80.
  7. Slavin JL. “Position of the American Dietetic Association: Health implications of dietary fiber”. Journal of the American Dietetic Association 108 (2008): 1716-1731.
  8. Duboc H., et al. “The Role of Diet in Functional Dyspepsia Management”. Frontiers in Psychiatry 11 (2020): 23.
  9. Popa SL., et al. “Exclusion Diets in Functional Dyspepsia”. Nutrients10 (2022): 2057.
  10. Talley NJ Ford AC. “Functional dyspepsia”. The New England Journal of Medicine 373 (2015): 1853-1863.
  11. Brownlee I. “The impact of dietary fibre intake on the physiology and health of the stomach and upper gastrointestinal tract”. Bioactive Carbohydrates and Dietary Fibre 4 (2014): 155-169.
  12. Sulaberidze G., et al. “Impact of food enriched with dietary fiber on patients with constipation-predominant irritable bowel syndrome”. Georgian Medical News3 (2017): 132-135.
  13. Capuano E. “The behavior of dietary fiber in the gastrointestinal tract determines its physiological effect, critical reviews”. Food Science and Nutrition16 (2017): 3543-3564.
  14. Suzuki H., et al. “Effect of lansoprazole on the epigastric symptoms of functional dyspepsia (ELF study): A multicentre, prospective, randomized, double-blind, placebo-controlled clinical trial”. United European Gastroenterology Journal6 (2013): 445-452.
  15. Suzuki H. “The Application of the Rome IV Criteria to Functional Esophagogastroduodenal Disorders in Asia”. Journal of Neurogastroenterology and Motility 2 (2017)325-333.
  16. Diet History Questionnaire II, National Cancer Institute.
  17. Roe L., et al. “Dietary intervention in primary care: Validity of the DINE method for diet assessment”. Family Practice 11 (1994): 375-381.
  18. Sulaberidze G., et al. “Frequency of Consumption of Different Food Groups among Adult Population of Tbilisi”. Collection of Scientific Works of the Tbilisi State Medical University 49 (2015): 104-106.
  19. Coding Manual for the 2010 NCI Diet History Questionnaire II One-Month with Serving Sizes Version. Diet History Questionnaire, Version 2.0. National Institutes of Health, Epidemiology and Genomics Research Program, National Cancer Institute (2010).
  20. Gebhardt Susan E and Robin G Thomas. “Nutritive Value of Foods”. U.S. Department of Agriculture, Agricultural Research Service, Home and Garden Bulletin 72 (2002).
  21. Stephen A., et al. “Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health”. Nutrition Research Reviews 30 (2017): 149-190.
  22. Manore MM. “Exercise and the institute of medicine recommendations for nutrition”. Current Sports Medicine Reports 4 (2005): 193-198.
  23. Pesce M., et al. “Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives”. World Journal of Gastroenterology 26 (2020): 456-465.
  24. Duncanson K., et al. “Mechanisms of Food-Induced Symptom Induction and Dietary Management in Functional Dyspepsia”. Nutrients 13 (2021): 1109.
  25. Goyal O., et al. “Low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet versus traditional dietary advice for functional dyspepsia: A randomized controlled trial”. Journal of Gastroenterology and Hepatology 37 (2021): 301-309.
  26. Futagami S., et al. “Comparison of clinical characteristics, eating behaviors, and clinical symptoms following fat intake in functional dyspepsia with functional dyspepsia with pancreatic enzyme abnormalities between Singapore and Japan”. Journal of Gastroenterology and Hepatology 8 (2022): 1525-1533.
  27. Khodarahmi M and Azadbakht L. “Dietary fat intake and functional dyspepsia”. Advanced Biomedical Research 5 (2016): 76.
  28. Duncanson KR., et al. “Food and functional dyspepsia: a systematic review”. Journal of Human Nutrition and Dietetics 3 (2018): 390-407.
  29. Jessica R., et al. “Low FODMAP diet beyond IBS: Evidence for use in other conditions”. Current Opinion in Pharmacology 64 (2022): 102208.
  30. Tack J., et al. “Evidence-Based and Emerging Dietary Approaches to Upper Disorders of Gut-Brain Interaction”. American Journal of Gastroenterology 6 (2021): 965-972.
  31. Tan VP. “The low-FODMAP diet in the management of functional dyspepsia in East and Southeast Asia”. Journal of Gastroenterology and Hepatology 32 (2017): 46-52.


Citation: Giga Sordia., et al. “Nutrition Profile of Women with Functional Upper Gastrointestinal Disorders”.Acta Scientific Medical Sciences 7.4 (2023): 194-204.


Copyright: © 2023 Giga Sordia., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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