Rouaa Babikir Ahmed¹*, Khalid Mohamed Khalid Elhussain^1,2, Babiker Ahmed Mohammed³, Doaa Abdullah Gasim⁴, Elyasaa Ahmed Gubartalla Ali⁵, Manal Mohammed Khalid Elhussien⁶, Nora Nahal Bouderba⁷, Mohammed Babiker Omer⁸, Rufaida Abdalla Ahmed⁹, Khalid Babikir Ahmed¹⁰and Ahmed Babekir Abdalla¹¹

¹Omdurman Islamic University, Faculty of Medical Laboratory Sciences, Sudan
²Omdurman Ahlia University, Faulty of Medicine, Sudan
³Karary University, Faculty of Medical Laboratory Sciences, Sudan
⁴International University of Africa, Sudan
⁵Institute of Endemic Diseases (IEND), Khartoum University, Sudan
⁶Al-Mughtaribeen University, Faulty of Medicine, Sudan
⁷University Tahri Mohammed, Faculty of Sciences of Nature and Life, Biology Department, Bechar, Algeria
⁸Al-Neelain University, Faculty of Medical Laboratory Science, Sudan
⁹Royal Bournemouth Hospital, Bournemouth, Dorset, UK
^10,11Modern Medical Center, Khartoum, Sudan

*Corresponding Author: Rouaa Babikir Ahmed, Omdurman Islamic University, Faculty of Medical Laboratory Sciences, Sudan.

Received: February 21, 2023; Published: March 02, 2023

Abstract

Aims: This study aimed to evaluate IL-6 and IL-1B levels and the iron profile (serum iron, ferritin, TIBC and TS%) in rheumatoid arthritis Sudanese patients.

Study Design: Case control. study.

Place and Duration of Study: This study was conducted at the Omdurman Islamic University, Sudan between 2018 and 2021.

Methodology: This study was conducted on 63 RA patients and 63 healthy individuals as control between 2018 and 2021. ELISA were used to measure the levels of IL-6and IL-1B, while the iron profile were carried out using automated chemical analyzer, the Transferrin saturation percentage TS% was calculated using the formula: TS (%)= [serum iron (ug/dl)/serum transferring (mg/dl)]17.

Result: IL-6 and IL1B levels were increased in anemic RA patients. In all patients, 98.4% of IL-6 levels and 28.5% of IL-1B levels had risen. IDA was common with 77% of anemic RA patients, their serum iron, ferritin and TS% show significant decrease. There was significant negative correlation between serum iron, ferritin, TIBC, and TS% with IL-6 in RA patients. There was statistically significant positive correlation between serum iron and IL1B in RA patients group.

Conclusion: The levels of IL-1β, IL-6 increased in RA patients and IDA showed 77% in case while there was association between IL-1β, IL-6 and serum iron in case. IDA is the most common and serious blood abnormality seen in RA. All of the above makes IL-1β, IL-6 and IDA with pivotal role in the pathophysiology of RA and this may affect the desirable option in the treatment of RA.

 Keywords: Interleukin-6 (IL-6); Interleukin-1B (IL-1B); Rheumatoid Arthritis (RA); Enzyme-linked Immunosorbent Assay (ELISA); Transferrin Saturation Percentage (TS%); Total Iron Binding Capacity (TIBC); Iron Deficiency Anemia (IDA)

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Citation

Citation: Rouaa Babikir Ahmed., et al. “Comparative Study of Interleukin-6, Interleukin-1B Levels and Iron Profile Among Sudanese Rheumatoid Arthritis Patients with Iron Deficiency Anemia”.Acta Scientific Medical Sciences 7.4 (2023): 29-35.

Copyright

Copyright: © 2022 Rouaa Babikir Ahmed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.