Dakhel Fahad Almubarak¹, Alanoud Abdulaziz Alharkan² and Mostafa Kofi³*

¹Family Medicine Resident, Prince Sultan Military Medical City Riyadh, Saudi Arabia
²Medical Intern, College of Medicine, Princess Nourah Bint Abdulrahman University Riyadh, Saudi Arabia
³Consultant PSMMC, Saudi Arabia

*Corresponding Author: Mostafa Kofi, Consultant PSMMC, Saudi Arabia.

Received: January 23, 2023; Published: February 10, 2023

Abstract

Diabetes is a metabolic disorder that is characterized by inadequate insulin secretion by pancreas or the lack in ability of the present insulin to function properly. Hence, diabetes forms a fertile media for several diseases and represents a greater risk on human-being health. Over decades, several strategies for management of diabetes have been tried by specialists, of which medical, herbal, and even live style modification has been tried.

Although diabetes mellitus represents a global growing epidemic disease, Till the moment there is no absolute solution at molecular level that targeting the disease. It’s well known that commensal bacteria have an un-neglectable role in bode metabolism since infancy both in healthy and diseased patients. On a clinical base when we studied beneficial role of probiotics at cellular level in animals. It was proved in many studies the beneficial role of probiotic for people with DM; nevertheless, further prospective interventional research, mostly using human models, are required to fully understand the impact of probiotic use in diabetic patients.

Indeed, we need to test the probability of probiotics usage in the outpatient clinic. As Based on our reliable understanding the beneficial role of probiotics in patients with diabetes mellites specially at the level of cell, both in clinical trials and animal studies, in addition to their excellent tolerability. Also, probiotics have proved their ability to decrease insulin and fasting blood glucose level in diabetic patients in a preclinical setting and in human trials. Recently, probiotics are used in a multiple diseases like inflammation, allergic reactions, and autoimmune diseases. However, the heterogeneity in these studies is high. For example, species used, the dose of probiotic used, and the magnitude of efficacy.

In our review, we focused on reviewing the relation between probiotics and troubled metabolism of our body sugar.

Keywords: Probiotics; Diabetes; Type 2 DM; Inflammation

References

1. “Diagnosis and classification of diabetes mellitus”. Diabetes Care1 (2014): S81-90.
2. Catley D., et al. “Evaluation of an adapted version of the Diabetes Prevention Program for low- and middle-income countries: A cluster randomized trial to evaluate "Lifestyle Africa" in South Africa”. PLoS Medicine4 (2022): e1003964.
3. Al-Quwaidhi AJ., et al. “Comparison of type 2 diabetes prevalence estimates in Saudi Arabia from a validated Markov model against the International Diabetes Federation and other modelling studies”. Diabetes Research and Clinical Practice3 (2014): 496-503.
4. Vaughan EM., et al. “Dual Therapy Appears Superior to Monotherapy for Low-Income Individuals With Newly Diagnosed Type 2 Diabetes”. Journal of Primary Care and Community Health4 (2017): 305-311.
5. Nille GC., et al. “Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property”. Frontiers in Pharmacology 12 (2021): 647887.
6. Yamashita T., et al. “Renal insufficiency without albuminuria is associated with peripheral artery atherosclerosis and lipid metabolism disorders in patients with type 2 diabetes”. Journal of Atherosclerosis and Thrombosis11 (2013): 790-797.
7. Ajala O., et al. “Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes”. The American Journal of Clinical Nutrition3 (2013): 505-516.
8. Masana L. “Pitavastatin in cardiometabolic disease: therapeutic profile”. Cardiovascular Diabetology 12 (2013): S2.
9. Davoodvandi A., et al. “An Update on the Effects of Probiotics on Gastrointestinal Cancers”. Frontiers in Pharmacology 12 (2021): 680400.
10. Liong MT., et al. “Effects of a synbiotic containing Lactobacillus acidophilus ATCC 4962 on plasma lipid profiles and morphology of erythrocytes in hypercholesterolaemic pigs on high- and low-fat diets”. The British Journal of Nutrition4 (2007): 736-744.
11. Taghizadeh M., et al. “Synbiotic food consumption reduces levels of triacylglycerols and VLDL, but not cholesterol, LDL, or HDL in plasma from pregnant women”. Lipids 2 (2014): 155-161.
12. Bustos AY., et al. “New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health”. Food Research International (Ottawa, Ont). 112 (2018): 250-162.
13. Ali SM., et al. “Hypolipidemic activity of lactic acid bacteria: Adjunct therapy for potential probiotics”. PLoS One6 (2022): e0269953.
14. Mazloom Z., et al. “Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: a clinical trial”. Iranian Journal of Medical Sciences 1 (2013): 38-43.
15. Obuchowska A., et al. “Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome”. International Journal of Molecular Sciences15 (2022).
16. Saxena N., et al. “Modulation of oxidative and antioxidative status in diabetes by asphaltum panjabinum”. Diabetes Care8 (2003): 2469-2470.
17. Friesen NT., et al. “Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin”. Diabetologia4 (2004): 676-685.
18. Willcox JK., et al. “Antioxidants and prevention of chronic disease”. Critical Reviews in Food Science and Nutrition4 (2004): 275-295.
19. Yadav H., et al. “Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats”. Nutrition (Burbank, Los Angeles County, Calif)1 (2007): 62-68.
20. Ma X., et al. “Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells”. Journal of Hepatology5 (2008): 821-30.
21. Al-Salami H., et al. “Probiotic Pre-treatment Reduces Gliclazide Permeation (ex vivo) in Healthy Rats but Increases It in Diabetic Rats to the Level Seen in Untreated Healthy Rats”. Archives of Drug Information1 (2008): 35-41.
22. Yamano T., et al. “Effects of the probiotic strain Lactobacillus johnsonii strain La1 on autonomic nerves and blood glucose in rats”. Life Sciences20 (2006): 1963-1967.
23. Zok C. “[The importance of the human intestinal microbiota]”. Deutsche medizinische Wochenschrift (1946) 24 (2014): 1282-1283.
24. Morelli L. “Yogurt, living cultures, and gut health”. The American Journal of Clinical Nutrition 99 (2014): 1248s-1250s.
25. Iebba V., et al. “Gut microbiota and the immune system: an intimate partnership in health and disease”. International Journal of Immunopathology and Pharmacology4 (2012): 823-833.
26. Guandalini S. “Probiotics for prevention and treatment of diarrhea”. Journal of Clinical Gastroenterology 45 (2011): S149-153.
27. Al-Salami H., et al. “Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats”. European Journal of Drug Metabolism and Pharmacokinetics 2 (2008): 101-106.
28. Zheng HJ., et al. “The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: A systematic review and meta-analysis of randomized controlled trials”. Pharmacological Research 142 (2019): 303-313.
29. Tabrizi R., et al. “The effects of probiotic and synbiotic supplementation on inflammatory markers among patients with diabetes: A systematic review and meta-analysis of randomized controlled trials”. European Journal of Pharmacology 852 (2019): 254-264.
30. Liang T., et al. “Probiotics supplementation improves hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes mellitus: An update of meta-analysis”. Critical Reviews in Food Science and Nutrition10 (2021): 1670-1688.
31. Pan J., et al. “Efficacy of probiotic supplement for gestational diabetes mellitus: a systematic review and meta-analysis”. The Journal of Maternal-Fetal and Neonatal Medicine2 (2019): 317-323.
32. Tabrizi R., et al. “The Effects of Synbiotic Supplementation on Glucose Metabolism and Lipid Profiles in Patients with Diabetes: a Systematic Review and Meta-Analysis of Randomized Controlled Trials”. Probiotics and Antimicrobial Proteins2 (2018): 329-342.
33. Li C., et al. “Effect of probiotics on metabolic profiles in type 2 diabetes mellitus: A meta-analysis of randomized, controlled trials”. Medicine (Baltimore)26 (2016): e4088.
34. Zhang C., et al. “Meta-analysis of randomized controlled trials of the effects of probiotics on type 2 diabetes in adults”. Clinical Nutrition (Edinburgh, Scotland)2 (2022): 365-373.
35. Zhang Q., et al. “Effect of probiotics on glucose metabolism in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials”. Medicina (Kaunas, Lithuania)1 (2016): 28-34.
36. Nabhani Z., et al. “The effect of synbiotic supplementation on atherogenic indices, hs-CRP, and malondialdehyde, as major CVD-related parameters, in women with gestational diabetes mellitus: a secondary data-analysis of a randomized double-blind, placebo-controlled study”. Diabetology and Metabolic Syndrome1 (2022): 87.
37. Suez J., et al. “Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT”. Cell6 (2018): 1406-1423.e16.
38. Freedman SB., et al. “Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis”. The New England Journal of Medicine21 (2018): 2015-2026.
39. Sun Z., et al. “Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential”. Critical Reviews in Food Science and Nutrition4 (2020): 670-683.

Citation

Citation: Mostafa Kofi., et al. “Probiotics in the Era of Diabetes, is it a Hope or a Hype; Narrative Review of Literature”.Acta Scientific Medical Sciences 7.3 (2023): 76-81.

Copyright

Copyright: © 2022 Mostafa Kofi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.