Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Mini Review Volume 7 Issue 2

Neonatal Bilateral Herpetic Keratitis Treated with Ribavirin Eye Drops at the Yaounde Gyneco-Obstetric And Pediatric Hospital: About A Case

Nomo AF1,2*, Akono Zoua ME1,3, Nanfack Ngoune C1,2, Mvilongo Tsimi C1,3, Nguepnang V1, Malla Eyebe G2, Dega A1, Koki G1,4, Epée E1,3, Omgbwa Eballe A1 and Bella AL1,2

1Faculty of Medicine and Biomedical Sciences of Yaoundé, Cameroon
2Yaoundé Gyneco-Obstetrics and Pediatric Hospital, Cameroon
3Yaoundé Central Hospital, Cameroon
4Douala Military Hospital, Cameroon

*Corresponding Author: Nomo AF, Faculty of Medicine and Biomedical Sciences of Yaoundé, Cameroon.

Received: December 13, 2022; Published: January 20, 2023


Introduction: Herpetic keratitis is inflammation of the cornea caused by herpes simplex viruses 1 and 2 (HSV-1 and HSV-2). HSV-2 keratitis is almost only encountered in neonatal infections causing amblyopia or even blindness. The mode of per-partum contamination during passage through the genital canal is very often recurrent. We report the case of a 33-day-old infant who presented with bilateral neonatal herpetic keratitis and which poses a therapeutical and prognostical problem.

Medical Observation: We reported the case of a 33-day-old infant, born to a primiparous mother by septic delivery at home, who presented with neonatal bilateral herpetic keratitis at two weeks of life without systemic involvement treated with ribavirin eye drops. The evolution was marked by the improvement of symptomatology with the disappearance of corneal opacities.

Conclusion: If not treated early, neonatal herpetic keratitis can lead to serious eye damage and even systemic lesions. New molecules such as ribavirin eye drops are proving their worth in the management of herpetic keratitis.

Keywords: Keratitis; Herpes; Newborn


  1. Mella L. “Ophthalmic herpes: clinical manifestations and treatments”. Pharmaceutical Sciences (2017): ffdumas-01552084e.
  2. Lonsberry BB. “Is herpes simplex virus keratitis a different disease in children?” Clinical and Experimental Optometry1 (2008): 115-119.
  3. OFFRET H. “Œil et virus: [report presented to the] French Society of Ophthalmology”. Paris: Masson; (2000): XXXI-547.
  4. Gallardo M J., et al. “Isolated herpes simplex keratoconjunctivitis in a neonate born by cesarean delivery”. Journal of AAPOS3 (2005): 285-287.
  5. Miserocchi E., et al. “Visual outcome in herpes simplex virus and varicella zoster virus uveitis”. Ophthalmology 109 (2002): 1532-1537.
  6. Management of genital herpes in pregnancy October 2014 NICE guideline (consensus guideline between RCOG/BASHH British Association for Sexual Health and HIV).
  7. Consensus conference. Management of mucocutaneous herpes in the immunocompetent subject (excluding ocular manifestations) ANAES (2001).
  8. Rousseau A and Labetoulle M. “Herpes and varicella-zoster in children: what are the particularities”. Réalités Ophtalmologiques (2015): 221-2.
  9. Devilliers M J., et al. “Ophthalmological effects of viral infections”. La Revue de Medecine Interne6 (2021): 401-410.
  10. Renesme L. “Neonatal herpes: epidemiology, clinical manifestations and management. Recommendations for clinical practice of the Collège national des gynécologues obstétriciens français (CNGOF)”. Gynecology, Obstetrics, Fertility and Senology12 (2017): 691-704.
  11. Ribavirin eye drops.


Citation: Nomo AF., et al. “Neonatal Bilateral Herpetic Keratitis Treated with Ribavirin Eye Drops at the Yaounde Gyneco-Obstetric And Pediatric Hospital: About A Case”.Acta Scientific Medical Sciences 7.2 (2023): 135-138.


Copyright: © 2022 Nomo AF., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

Contact US