Evaluation of the Relationship Between Serum Level of Vitamin D3 and Endothelial Function Tests in Patients with Migraine Headache
Mohammadreza Rezvani Valuklolaee1, Zahra Mirzaasgari2, Fatemeh Afrashteh1
*, Roya Ghafoury1 and Rayan Rajabi1
1School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Assistant Professor of Neurology, Iran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Fatemeh Afrashteh, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
December 16, 2022; Published: January 18, 2023
Introduction: Migraine is a severe headache type and has a negative effect on quality of life. Studies have confirmed the presence of vitamin D receptors in different regions of the human brain and the relation between vitamin D deficiency and neurologic disorders. Here we evaluated the association between migraine features and serum vitamin D levels.
Method: In this case analytical study, we included patients who were referred to the General Neurology Clinic from march 2020 to march 2021 with these criteria: Over 18 years of age, having a diagnosis of migraine with at least 3 attacks per month. Exclusion criteria included risk of vascular diseases including a history of heart attack or stroke, diabetes, hypertension, smoking, peripheral vascular disease, patients using statins, and patients who were in the acute migraine attack phase. Flow mediated dilation (FMD) of the brachial artery depending on the blood flow and carotid intima-media thickness (IMT) score were measured for the participants.
Results: The correlation coefficient between FMD and IMT values was r = -0.428 (p = 0.003). This association was not notable in migraine patients with aura (p = 0.065) but in the group of patients without aura, the results were significant (r = 0.379, p = 0.025). FMD and IMT were not associated with serum vitamin D level in all patients (p = 0.802 and p = 0.785 respectively).
Conclusion: We did not found a correlation between serum vitamin D level and FMD or IMT in migraine. FMD and IMT were correlated with each other only in patients without aura. Further studies are needed to investigate the role of vitamin D level in migraine features.
Keywords: Vitamin D; Migraine; Flow Mediated Dilation; Carotid Intima-Media Thickness
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