Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Short Communication Volume 7 Issue 1

Zebrafish: A Powerful Tool in Drug Discovery and Development

Neeraj Verma*

Hygia College of Pharmacy, Lucknow, India

*Corresponding Author: Neeraj Verma, Hygia College of Pharmacy, Lucknow, India.

Received: November 21, 2022; Published: December 07, 2022

Animal models are non-human animal species which may be used to recognize unique biological methods and to acquire informations which could offer a perception into working of different organisms. Animal models are crucial tool for addressing essential scientific questions on illnesses and for the development of new therapeutic approaches. Among the various version organisms, the zebrafish (Danio rerio) is one of the leading models to look at developmental biology, most cancers, toxicology, drug discovery, and molecular genetics. The zebrafish has been used as a good opportunity vertebrate model for the study of human skeletal illnesses, because of its genetic manipulation, excessive fecundity, outside fertilization, transparency of hastily growing embryos, and occasional renovation fee.


  1. Gore AV., et al. “Vascular development in the zebrafish”. Cold Spring Harbor Perspectives in Medicine5 (2012): a006684.
  2. Kanungo J., et al. “Zebrafish model in drug safety assessment”. Current Pharmaceutical Design34 (2014): 5416-5429.
  3. Kalueff AV., et al. “Zebrafish as an emerging model for studying complex brain disorders”. Trends in Pharmacological Sciences2 (2014): 63-75.
  4. Guyon JR., et al. “Modeling human muscle disease in zebrafish”. Biochimica et Biophysica Acta 2 (2007): 205-215.
  5. Weinstein B. “Vascular cell biology in vivo: A new piscine paradigm?” Trends in Cell Biology 9 (2002): 439-445.
  6. Lieschke GJ, et al. “Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish”. Blood10 (2001): 3087-3096.
  7. Zhao S., et al. “A fresh look at zebrafish from the perspective of cancer research”. Journal of Experimental and Clinical Cancer Research 80 (2015).
  8. Santoriello C and Zon LI. “Hooked! Modeling human disease in zebrafish”. The Journal of Clinical Investigation 7 (2012): 2337-2343.
  9. Brand M., et al. “Keeping and raising zebrafish”. In: Nusslein-Volhard C, Dahm R, editors. Zebrafish: A Practical Approach. Oxford: Oxford University Press; (2002): 7-37.
  10. Carpio Y and Estrada MP. “Zebrafish as a genetic model organism”. Biotecnologia Aplicada 23 (2006): 265-270.
  11. Pelegri F. “Mutagenesis”. In: Nusslein-Volhard C, Dahm R, editors. Zebrafish: A Practical Approach”. Oxford: Oxford University Press; (2002): 145-174.
  12. Lele Z and Krone PH. “The zebrafish as a model system in developmental, toxicological and transgenic research”. Biotechnology Advances1 (1996): 57-72.
  13. Chitramuthu BP. “Modeling human disease and development in zebrafish”. Human Genetic Embryology 3 (2013): e108.
  14. Gama Sosa MA., et al. “Modeling human neurodegenerative diseases in transgenic systems”. Human Genetics 131 (2013): 535-563.
  15. Berman J., et al. “The zebrafish as a tool to study hematopoiesis, human blood diseases, and immune function”. Advances in Hematology2 (2012).
  16. Brownlie A., et al. “Positional cloning of the zebrafish sauternes gene: A model for congenital sideroblastic anaemia”. Nature Genetics 20 (1998): 244-250
  17. Sehnert AJ., et al. “Cardiac troponin T is essential in sarcomere assembly and cardiac contractility”. Nature Genetics 31 (2002): 106-110.
  18. Lin YY. “Muscle diseases in the zebrafish”. Neuromuscular Disorders 22 (2012): 673-684.
  19. Liu S and Leach SD. “Zebrafish models for cancer”. Annual Review of Pathology 6 (2011): 71-93.
  20. Patton EE., et al. “BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma”. Current Biology 15 (2005): 249-254.
  21. Sarath Babu N., et al. “1-Methyl-4- phenyl-1, 2,3, 6-tetrahydropyridine induced Parkinson’s disease in zebrafish”. Proteomics 16 (2016): 14071-14420.
  22. Chakravarty S., et al. “Chronic unpredictable stress (CUS)-induced anxiety and related mood disorders in a zebrafish model: Altered brain proteome profile implicates mitochondrial dysfunction”. PLoS One 8 (2013): e63302.


Citation: Neeraj Verma. “Zebrafish: A Powerful Tool in Drug Discovery and Development”.Acta Scientific Medical Sciences 7.1 (2023): 12-14.


Copyright: © 2022 Neeraj Verma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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