Abin Varghese¹* and Vanamala Alwar²

¹Research Scholar, Srinivas University, Mangalore, Karnataka, India
²Department of Clinical Pathology, St John’s Medical College, Bangalore, Karnataka, India

*Corresponding Author: Abin Varghese, Research Scholar, Srinivas University, Mangalore, Karnataka, India.

Received: November 21, 2022; Published: November 29, 2022

Abstract

According to the World Health Organisation, dengue is endemic in more than 100 countries. there are an estimated 390 million or more cases of dengue annually worldwide, and 40% of the world population. Understanding the pathophysiology of dengue virus infection along with an early diagnosis of dengue fever with the aid of laboratory parameters and clinical evaluation helps in the management of dengue fever. The objective of this study was to analyze the hematological parameters which will help in the early diagnosis of dengue syndromes. Most patients are clinically asymptomatic. However severe dengue fever may cause increased vascular permeability with vascular leakage, hemoconcentration, hypovolemic shock, and bleeding manifestations due to thrombocytopenia. The parameters studied were hemoglobin concentration, total leucocyte count, differential leucocyte count, platelet count, and Leishman-stained peripheral smear examination. In our study, out of 100 dengue-positive patients proven by the ELISA method; the common laboratory finding was thrombocytopenia (97%). Leucopenia was found in only 13% of patients and 18% of patients had relative lymphocytosis. Of 100 patients 81% of patients showed the presence of reactive lymphocytes. Also noted was a raised hematocrit in 21% of patients. The correlation of dengue IgM antibody with hematological parameters was studied. The severity of thrombocytopenia depends inversely on the titre of antibody level in the patient.

Keywords: Dengue Fever; Dengue Hemorrhagic Fever; Dengue Shock Syndrome; Hemoconcentration; Thrombocytopenia; Dengue IgM Antibody

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Citation

Citation: Abin Varghese and Vanamala Alwar. “Correlation Between Hematological and Serological Parameters in Dengue Fever Patients”.Acta Scientific Medical Sciences 6.12 (2022): 127-133.

Copyright

Copyright: © 2022 Abin Varghese and Vanamala Alwar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.