Neuroprotective Effect of Monodora myristica on the Lead-induced Injury of the Cerebral Cortex
of Male Wistar Rats
Orish CN1*, Valentine Chidozie Amasiatu2 and Chidi U Betrand3
1Department of Anatomy, Faculty of Basic Medical Science, University of Port-Harcourt, Rivers State, Nigeria
2Department of Anatomy, Gregory University Uturu, Uturu, Nigeria
3Department of Computer Science, Federal University of Technology - Owerri, Nigeria
*Corresponding Author: Orish CN, Department of Anatomy, Faculty of Basic Medical Science, University of Port-Harcourt, Rivers State, Nigeria.
July 01, 2022; Published: November 11, 2022
Background: Lead (Pb) is one of the most common environmental toxicants, exposure to which can cause significant neurotoxicity and an associated decline in brain function. Plant-derived products with antioxidants activity are useful in reducing lead-induced neurotoxicity. This study investigated neuroprotective and antioxidant properties of the aqueous Monodora myristica against lead-induced neurotoxicity in male Wistar rats.
Methods: Six groups of six weight-matched animals each, were used for the study. Group 1 (normal control) was treated with deionized water and group 2 (toxic control) with lead acetate at the doses of 50 mg/kg b.wt, whereas group 3 received M. myristica 40 mg/kg only, groups 4,5, and 6 were simultaneously treated with lead (50 mg/kg b.wt), and 40 mg/kg, 80 mg/kg, and 160 mg/kg of M. myristica respectively. The treatment was administered orally for 42 days. Their biochemical and histopathological investigations were carried out following animal sacrifice at the end of the study period. The neuroprotective effect of M. myristica was assessed by measuring redox status (malondialdehyde), enzymatic antioxidant activities (Superoxide dismutase, Catalase, Glutathione peroxidase and glutathione reductase) and histopathology of the cerebral cortex.
Results: The increase in the malondialdehyde, the decrease in the activity of antioxidant enzymes (Catalase, Glutathione peroxidase and reductase), and the altered histology of the brain induced neurotoxicity by lead acetate were mitigated in the brain of rats treated with M. myristica.
Conclusion: Aqueous M. myristica has a neuroprotective role against lead-induced neurotoxicity probably mediated through its antioxidant properties.
Keywords: Neurotoxicity; Monodora myristica; Antioxidant; Lead
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