Fathia M Khattab1, Rania Ghonaim2* and Elsayed M Khater1
1Assistant Professor of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Egypt
2Assistant Professor of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt
*Corresponding Author: Rania Ghonaim, Assistant Professor of Clinical Pathology, Faculty of Medicine, Zagazig University, Egypt.
Received: August 10, 2022; Published: August 23, 2022
Background: Several theories suggest melanocyte death in vitiligo, such as the oxidative stress theory. Vaspin is a steady marker for the assessment of the oxidative stress events. Narrow-band ultra-violet B (NB-UVB) therapy has developed vaspin in psoriasis and atopic dermatitis; but there is a little information on the impact in vitiligo and the association among vaspin rates and severity of disease and repigmentation. The relationship among serum vaspin levels and activity of vitiligo and its severity remained controversial.
Objective: Investigating NB-UVB photo-therapy effect on vaspin in Vitiligo cases.
Patients and Methods: In 56 vitiligo patients, serum vaspin levels had been measured before and following presentation in 48 NB-UVB sessions. Base-line vaspin rates of patients were compared to control rates for the stable participants of age and gender. Vitiligo region index (VASI) scoring method was used to test clinical response.
Results: The mean vaspin serum in the controls was significantly lower (P < 0.001). A substantial increase in Vaspin (P < 0.001) was observed following photo-therapy. The elevation in vaspin was adversely correlated with base-line vaspin levels. Also, there has been a significant correlation among vaspin levels and the severity index for Vitiligo Region (VASI).
Conclusion: NB-UVB enhancement of vitiligo is accompanying with an up-regulation of serum vaspin records. We, consequently, believe that vaspin has a significant function in the pathogenesis of vitiligo and contributes to its therapeutic effectiveness.
Keywords: Vaspin; Vitiligo; VASI; Ultraviolet B Photo-therapy
Citation: Rania Ghonaim., et al. “Oxidative Stress Levels in Relation to Vitiligo Severity and Activity”.Acta Scientific Medical Sciences 6.9 (2022): 36-40.
Copyright: © 2022 Rania Ghonaim., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.