Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Case Review Volume 6 Issue 10

The ‘Knee-jerk’ or ‘Blood-jerk Reaction’ - A Rise in the Alkaline Ph of the Blood!

Robert O Young*

Naturopathic Practitioner, Department of Research, pH Miracle, USA

*Corresponding Author: Robert O Young, Naturopathic Practitioner, Department of Research, pH Miracle, USA.

Received: September 02, 2022; Published: September 21, 2022

What does it really mean?


I am certain that you have heard and even experienced a ‘knee-jerk reaction’. I am also certain that you have never heard of a ‘blood-jerk reaction’ but you have experienced a ‘blood-jerk reaction’ without understanding the physiology. I believe it is not only important to understand the ‘blood-jerk reaction’ but critical in avoiding ALL sickness and disease, especially All cancerous conditions!


  1. G Nitin and J Calvert. “Understanding blood gases/acid-base balance”. Paediatrics and Child Health4 (2012): 142-148.
  2. J C Atherton. “Acid-base balance: maintenance of plasma pH”. Anaesthesia and Intensive Care Medicine11 (2009): 557-561.
  3. A Durward and I Murdoch. “Understanding acid-base balance”. Current Paediatrics7 (2003): 513-519.
  4. Young RO and Young SR. “The pH Miracle for Weight Loss”. Hachett Publishing Group, (2005).
  5. Young RO and Young SR. “The pH Miracle revised and updated”. Hachette Publishing Group, (2010).
  6. Passey C. “Reducing the Dietary Acid Load: How a More Alkaline Diet Benefits Patients With Chronic Kidney Disease”. Dietetic Department, Wessex Kidney Centre, Portsmouth Hospitals NHS Trust, Portsmouth, Hampshire, United Kingdom. Journal of Renal Nutrition3 (2017): 151-160.
  7. Gonzaleza C A and Riboli L. “Diet and cancer prevention: Contributions from the European Prospective Investigation into Cancer and Nutrition (EPIC) study”. European Journal of Cancer14 (2010): 2555-2562.
  8. American Cancer Society, ACS Guidelines for Nutrition and Physical Activity.
  9. Centers for Disease Control and Prevention, Heart Disease Facts.
  10. Nordqvist C. “Nutrition: What is it and why is it important?” Medical News Today, September 1, (2017).
  11. Schwalfenberg G K. “The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health?” Journal of Environmental Public Health 2012 (2012): 727630.
  12. Silvina L and V S Lagari. “The Role of Diet in Osteoporosis Prevention and Management”. Current Osteoporosis Reports 4 (2012): 296-302.
  13. AA Welch., et al. “A higher alkaline dietary load is associated with greater indexes of skeletal muscle mass in women”. Osteoporosis International6 (2013): 1899-1908.
  14. Ströhle A., et al. “Estimation of the diet-dependent net acid load in 229 worldwide historically studied hunter-gatherer societies”. American Journal of Clinical Nutrition 2 (2010): 406-412.
  15. Sebastian A., et al. “Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors”. American Journal of Clinical Nutrition 6 (2002): 1308-1316.
  16. Frassetto L., et al. “Diet, evolution and aging—the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet”. European Journal of Nutrition 5 (2001): 200-213.
  17. Konner M., et al. “Paleolithic nutrition: twenty-five years later”. Nutrition in Clinical Practice6 (2010): 594-602.
  18. Lindeman RD and Goldman R. “Anatomic and physiologic age changes in the kidney”. Experimental Gerontology4-5 (1986): 379-406.
  19. Reddy ST., et al. “Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism”. American Journal of Kidney Diseases2 (2002): 265-274.
  20. Malov YS and Kulikov AN. “Bicarbonate deficiency and duodenal ulcer”. Terapevticheskii Arkhiv 2 (1998): 28-32.
  21. Ohman H and Vahlquist A. “In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis”. Acta Dermato-Venereologica5 (1994): 375-379.
  22. Ferris DG., et al. “Variability of vaginal pH determination by patients and clinicians”. Journal of the American Board of Family Medicine4 (2006): 368-373.
  23. Remer T and Manz F. “Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein”. American Journal of Clinical Nutrition6 (1994): 1356-1361.
  24. Remer T. “Influence of diet on acid-base balance”. Seminars in Dialysis4 (2000): 221-226.
  25. Fenton TR., et al. “Low urine pH and acid excretion do not predict bone fractures or the loss of bone mineral density: a prospective cohort study”. BMC Musculoskeletal Disorders 11 (2010).
  26. Boelsma E., et al. “Human skin condition and its associations with nutrient concentrations in serum and diet”. American Journal of Clinical Nutrition 2 (2003): 348-355.
  27. Ince BA., et al. “Lowering dietary protein to U.S. recommended dietary allowance levels reduces urinary calcium excretion and bone resorption in young women”. Journal of Clinical Endocrinology and Metabolism8 (2004): 3801-3807.
  28. Boron WF. “Regulation of intracellular pH”. Advances in Physiology Education 28 (2004): 160-179.
  29. Remer T and Manz F. “Potential renal acid load of foods and its influence on urine pH”. Journal of the American Dietetic Association7 (1995): 791-797.
  30. Fenton TR., et al. “Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis”. American Journal of Clinical Nutrition 4 (2008): 1159-1166.
  31. Sebastian A and Morris RC. “Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate”. New England Journal of Medicine4 (1994): 279.
  32. Dawson-Hughes B., et al. “Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women”. Journal of Clinical Endocrinology and Metabolism1 (2009): 96-102.
  33. Heaney RP., et al. “Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D”. Journal of the American College of Nutrition2 (2003): 142-146.
  34. Schwalfenberg GK., et al. “Addressing vitamin D deficiency in Canada: a public health innovation whose time has come”. Public Health6 (2010): 350-359.
  35. Lu KC., et al. “Influence of metabolic acidosis on serum 1,25 (OH)2D3 levels in chronic renal failure”. Mineral and Electrolyte Metabolism6 (1995): 398-402.
  36. Fenton TR., et al. “Phosphate decreases urine calcium and increases calcium balance: a meta-analysis of the osteoporosis acid-ash diet hypothesis”. Nutrition Journal 8 (2009).
  37. Hulley SB., et al. “The effect of supplemental oral phosphate on the bone mineral changes during prolonged bed rest”. Journal of Clinical Investigation12 (1971): 2506-2518.
  38. Fenton TR., et al. “Meta-analysis of the effect of the acid-ash hypothesis of osteoporosis on calcium balance”. Journal of Bone and Mineral Research11 (2009): 1835-1840.
  39. Supplee JD., et al. “Soda intake and osteoporosis risk in postmenopausal American-Indian women”. Public Health Nutrition (2011): 1-7.
  40. Fenton TR., et al. “Causal assessment of dietary acid load and bone disease: a systematic review and meta-analysis applying Hill's epidemiologic criteria for causality”. Nutrition Journal 10 (2011).
  41. Frassetto LA., et al. “Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet”. American Journal of Physiology—Renal Physiology 2 (2007): F521-F525.
  42. Frings-Meuthen P., et al. “High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses”. Journal of Applied Physiology2 (2011): 537-542.
  43. Cappuccio FP., et al. “High blood pressure and bone-mineral loss in elderly white women: a prospective study”. Lancet9183 (1999): 971-975.
  44. Devine A., et al. “A longitudinal study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women”. American Journal of Clinical Nutrition4 (1995): 740-745.
  45. Morris RC., et al. “Relationship and interaction between sodium and potassium”. Journal of the American College of Nutrition3 (2006): 262S-270S.
  46. Barzel US and Massey LK. “Excess dietary protein may can adversely affect bone”. Journal of Nutrition6 (1998): 1051-1053.
  47. Heaney RP and Layman DK. “Amount and type of protein influences bone health”. American Journal of Clinical Nutrition 5 (2008): 156S-157S.
  48. Dawson-Hughes B., et al. “Alkaline diets favor lean tissue mass in older adults”. American Journal of Clinical Nutrition 3 (2008): 662-665.
  49. Garibotto G., et al. “Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance”. Mineral and Electrolyte Metabolism1-3 (1996): 58-61.
  50. Caso G and Garlick PJ. “Control of muscle protein kinetics by acid-base balance”. Current Opinion in Clinical Nutrition and Metabolic Care1 (2005): 73-76.
  51. Webster MJ., et al. “Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance”. Medicine and Science in Sports and Exercise8 (1993): 960-965.
  52. McSherry E and Morris RC. “Attainment and maintenance of normal stature with alkali therapy in infants and children with classic renal tubular acidosis”. Journal of Clinical Investigation2 (1978): 509-527.
  53. Frassetto L., et al. “Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women”. Journal of Clinical Endocrinology and Metabolism1 (1997): 254-259.
  54. Wass JAH and Reddy R. “Growth hormone and memory”. Journal of Endocrinology2 (2010): 125-126.
  55. Frassetto L., et al. “Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women”. Journal of Clinical Endocrinology and Metabolism2 (2005): 831-834.
  56. Vormann J., et al. “Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain”. Journal of Trace Elements in Medicine and Biology2-3 (2001): 179-183.
  57. Zofková I and Kancheva RL. “The relationship between magnesium and calciotropic hormones”. Magnesium Research1 (1995): 77-84.
  58. Schwalfenberg G. “Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series”. Journal of the American Board of Family Medicine 1 (2009): 69-74.
  59. Groos E., et al. “Intravesical chemotherapy. Studies on the relationship between pH and cytotoxicity”. Cancer6 (1986): 1199-1203.
  60. Smith SR., et al. “Tumour pH and response to chemotherapy: an in vivo 31P magnetic resonance spectroscopy study in non-Hodgkin’s lymphoma”. British Journal of Radiology 766 (1991): 923-928.
  61. Raghunand N and Gillies RJ. “pH and chemotherapy”. Novartis Foundation Symposium 240 (2001): 199-211.
  62. Raghunand N., et al. “Enhancement of chemotherapy by manipulation of tumour pH”. British Journal of Cancer7 (1999): 1005-1011.


Citation: Robert O Young. “The ‘Knee-jerk’ or ‘Blood-jerk Reaction’ - A Rise in the Alkaline Ph of the Blood!”.Acta Scientific Medical Sciences 6.10 (2022): 23-35.


Copyright: © 2022 Robert O Young. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
    Use KmsPico to obtain a Windows and Office license.

Contact US