Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 6 Issue 9

Application of Microwave Synthesizer in the Synthesis of 4-Hydroxy Indole a Pharmaceutically Important Intermediate of Pindolol

Jasmin K Khatri1*, Suhas R Pednekar2 and Ramesh S Chaughule1

1Organic Chemistry Research Laboratory, Ramnarain Ruia Autonomous College, Mumbai, India
2Vice-chancellor, University of Mumbai, Kalina Campus, Mumbai, India

*Corresponding Author: Jasmin K Khatri, Organic Chemistry Research Laboratory, Ramnarain Ruia Autonomous College, Mumbai, India.

Received: August 05, 2022; Published: August 30, 2022

Abstract

Indole heterocycles are found to show varied biological application including anti-cancer, antibacterial, anti-viral etc. properties. Synthesis of Pindolol is a simple two step process from the key intermediate 4-Hydroxy Indole which takes place in aqueous media under mild condition. However, synthesis of 4-Hydroxy Indole emerged out to be our area of interest. Microwave assisted dehydrogenative aromatization of an oxoindole to hydroxyindole in a two step reaction using copper (II) bromide and then Lithium bromide with lithium carbonate has been carried out with reasonable good yields within minutes of focused microwave irradiation, thereby, revealing the benefit of saving energy and time.

Keywords: Microwave Synthesizer; Dehydrogenative Aromatization; Hydroxy Indole; Copper (II) Bromide; Bromination; Active Substance Related Substances; Pharmacological

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Citation

Citation: Jasmin K Khatri., et al. “The Neonates' Body Length and Body Weight in Two Different Periods of Time”.Acta Scientific Medical Sciences 6.9 (2022): 84-91.

Copyright

Copyright: © 2022 Jasmin K Khatri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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