Evaluation of Biochemical Markers of Hemophagocytic Lymphohistiocytosis with Severity and Outcome of Dengue Fever
Tarun Betha1, Ajit Tambolkar2, Vihita Kulkarni-Nivargi3, Arun Bahulikar4 and Deepak Phalgune5*
1DNB (Medicine), Senior Resident, Department of Medicine, Poona Hospital and Research Centre, Pune, India
2MD (Medicine), Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, India
3DNB (Medicine), Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, India
4MD (Medicine), HoD and Consultant Physician, Department of Medicine, Poona Hospital and Research Centre, Pune, India
5MD (P & SM), PhD, Research Consultant, Department of Research, Poona Hospital and Research Centre, Pune, India
*Corresponding Author: Deepak Phalgune, MD (P & SM), PhD, Research Consultant, Department of Research, Poona Hospital and Research Centre, Pune, India.
March 14, 2022; Published: April 20, 2022
Background: The aim of the present study was to identify an association between biochemical markers of hemophagocytic lymphohistiocytosis such as serum ferritin, serum triglycerides, serum fibrinogen and serum lactate dehydrogenase with the severity of dengue fever and disease outcome.
Material and Methods: Ninety patients aged ≥ 18 years with dengue fever confirmed with a serology- dengue non-structural protein 1 antigen-positive were included for this prospective observational study. The patients underwent tests that included serum ferritin, serum triglycerides, serum lactate dehydrogenase, and serum fibrinogen. The primary outcome measure was to find an association of serum triglycerides, serum lactate dehydrogenase,, serum ferritin and serum fibrinogen with the severity of dengue disease.
Results: The median serum ferritin (870.0 ng/mL Vs 95.0 ng/mL), the mean serum lactate dehydrogenase (235 ± 36 U/l Vs 192 ± 24 U/l) and mean serum triglyceride (230 ± 33 mg/dL Vs 192 ± 24 mg/dL) were significantly higher in severe dengue fever patients as compared to dengue fever patients. The mean fibrinogen was 180 ± 45 mg/dL and 197 ± 46 mg/dL in severe dengue fever patients and dengue fever patients respectively (p-value = 0.149).
Conclusions: Serum ferritin, serum lactate dehydrogenase and serum triglyceride levels were found to have a significant association with dengue disease severity.
Keywords: Dengue Fever; Serum Ferritin; Serum Fibrinogen; Serum Lactate Dehydrogenase; Serum Triglycerides
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