Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 6 Issue 2

The Need of Integrated Tools for the Study of Occupational Exposure to Allergens

Maria Concetta D’Ovidio1*, Pasquale Capone1, Andrea Lancia1,2, Paola Melis1, Giovanna Tranfo1, Carlo Grandi1 and Isabella Annesi-Maesano3

1Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), Monte Porzio Catone (Rome), Italy
2Department of Environmental Biology, Sapienza University of Rome, Rome, Italy
3IDESP, University of Montpellier and Inserm, Montpellier, France

*Corresponding Author: Maria Concetta D’Ovidio, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers’ Compensation Authority (INAIL), Monte Porzio Catone (Rome), Italy.

Received: November 30, 2021; Published: January 17, 2022

Abstract

The workplaces represent an important source of exposure to a variety of biological, chemical and physical agents. The aim of this paper is to investigate the topic of allergens in occupational settings, promoting the practice of human biomonitoring, which is now mostly used for environmental exposure to chemical agents in the management of occupational allergies. We conducted a search on the websites of international institutions and/or associations focusing on allergens potentially relevant in workplaces. Allergy-related biomonitoring and biomarkers were included, and data on work-related allergic diseases available on the Italian Workers’ Compensation Authority (INAIL) data bank were collected in cumulative years 2014-2019. Both biological- and chemical-derived allergens found in industry and services, as well as in agriculture, may induce respiratory and cutaneous effects, resulting in work-related diseases. The number of cases confirmed in cumulative years 2014-2019, included 97 cases of allergic rhinitis unspecified, 409 cases of predominantly allergic asthma diseases, 916 cases of allergic contact dermatitis and 10 cases of allergic urticaria. The number of cases of allergic rhinitis unspecified was the same in both industry and services and agriculture, while the majority of cases of predominantly allergic asthma were found in industry and services (276) with respect to agriculture (129). The survey and/or notification of work-related allergy cases, jointly with data from environmental monitoring, human biomonitoring, specific biomarkers, individual sensitization and health surveillance practice play a key role in the building of a network aimed at improving preventive measures in the field of occupational allergies.

Keywords: Human Biomonitoring; Occupational Allergies; Workplaces; Environmental Exposure; Health Surveillance; Occupational Allergens; Exposome

References

  1. Robertson S., et al. “Bioaerosol exposure from composting facilities and health outcomes in workers and in the community: a systematic review update”. International Journal of Hygiene and Environmental Health 3 (2019): 364-386.
  2. Hachem M., et al. “Exposure to traffic air pollutants in taxicabs and acute adverse respiratory effects: a systematic review”. Science of The Total Environment 693 (2019): 1334-1339.
  3. Grandi C and D’Ovidio MC. “Balance between health risks and benefits for outdoor workers exposed to solar radiation: an overview on the role of near infrared radiation alone and in combination with other solar spectral bands”. International Journal of Environmental Research and Public Health 4 (2020): 1357.
  4. Anderson SE and Meade BJ. “Potential health effects associated with dermal exposure to occupational chemicals”. Environmental Health Insights 1 (2014): 51-62.
  5. Nakonechna A., et al. “Occupational asthma, rhinitis, contact dermatitis, and severe milk allergy caused by primary occupational exposure to casein”. Annals of Allergy, Asthma and Immunology 2 (2019): 224-225.
  6. Scott JF., et al. “Atopy and sensitization to allergens known to cause systemic contact dermatitis”. Dermatitis1 (2019): 62-66.
  7. D’Ovidio MC., et al. “Climate change and occupational allergies: an overview on biological pollution, exposure and prevention”. Annali dell'Istituto Superiore di Sanità 3 (2016): 406-414.
  8. D’Ovidio MC., et al. “Biological occupational allergy: protein microarray for the study of laboratory animal allergy (LAA)”. AIMS Public Health4 (2018): 352-365.
  9. Claeson AS., et al. “Comorbidity of airway inflammatory diseases in chemical and building-related intolerance”. Journal of Occupational and Environmental Medicine 4 (2018): 295-300.
  10. Azuma K., et al. “Evaluating prevalence and risk factors of building-related symptoms among office workers: seasonal characteristics of symptoms and psychosocial and physical environmental factors”. Environmental Health and Preventive Medicine 22 (2017): 38.
  11. Lu CY., et al. “Personal, psychosocial and environmental factors related to sick building syndrome in official employees of Taiwan”. International Journal of Environmental Research and Public Health 1 (2018): 7.
  12. Saeki Y., et al. “Clinical and allergological analysis of ocular manifestations of sick building syndrome”. Clinical Ophthalmology 11 (2017): 517-522.
  13. European Academy of Allergy and Clinical Immunology (EAACI). “Global atlas of allergy”. Ed by C.A. Akdis, I. Agache (2014).
  14. Antó JM., et al. “Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar”. Journal of Allergyand Clinical Immunology 4 (2012): 943-954 e944.
  15. Lund G., et al. “Antibody repertoire complexity and effector cell biology determined by assays for IgE-mediated basophil and T-cell activation”. Journal of Immunological Methods1-2 (2012): 4-20.
  16. Willumsen N., et al. “The complexity of allergic patients' IgE repertoire correlates with serum concentration of allergen-specific IgE”. Clinical and Experimental Allergy42 (2012): 1227-1236.

 

  1. Wild CP. “Complementing the genome with an exposome: the outstanding challenge of environmental exposure measurement in molecular epidemiology”. Cancer Epidemiology, Biomarkers and Prevention 8 (2005): 1847-1850.
  2. Niedzwiecki MM., et al. “The exposome: molecules to populations”. Annual Review of Pharmacology and Toxicology 59 (2019): 107-127.
  3. Cecchi L., et al. “External exposome and allergic respiratory and skin diseases”. Journal of Allergy and Clinical Immunology 3 (2018): 846-857.
  4. Eyles E., et al. “Occupied with classification: which occupational classification scheme better predicts health outcomes?” Social Science and Medicine 227 (2019): 56-62.
  5. Schulte PA and Hauser JE. “The use of biomarkers in occupational health research, practice, and policy”. Toxicology Letters 1 (2012): 91-99.
  6. Faisandier L., et al. “Occupational exposome: a network-based approach for characterizing occupational health problems”. Journal of Biomedical Informatics4 (2011): 545-452.
  7. Holland N. “Future of environmental research in the age of epigenomics and exposomics”. Reviews on Environmental Health 1-2 (2017): 45-54.
  8. Vlaanderen J., et al. “Application of OMICS technologies in occupational and environmental health research; current status and projections”. Occupational and Environmental Medicine 2 (2010): 136-143.
  9. Angerer J., et al. “Human biomonitoring: state of the art”. International Journal of Hygiene and Environmental Health 3-4 (2007): 201-228.
  10. Zissler UM., et al. “Current and future biomarkers in allergic asthma”. Allergy4 (2016): 475-494.
  11. Santarelli GD., et al. “Establishing urinary leukotriene E(4) as a diagnostic biomarker for chronic rhinosinusitis with comorbid asthma and atopy”. Otolaryngology–Head and Neck Surgery5 (2019): 764-769.
  12. Shen Y., et al. “Association between interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis”. Human Immunology 9 (2014): 991-995.
  13. Donovan BM., et al. “The current state of omics technologies in the clinical management of asthma and allergic diseases”. Annals of Allergy, Asthma and Immunology 6 (2019): 550-557.
  14. Gouveia D., et al. “Ecotoxicoproteomics: a decade of progress in our understanding of anthropogenic impact on the environment”. Journal of Proteomics 198 (2019): 66-77.
  15. Quirce S and Sastre J. “Occupational asthma: clinical phenotypes, biomarkers, and management”. Current Opinion in Pulmonary Medicine 25 (2019): 59-63.
  16. Harper M., et al. “Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science”. Journal of Exposure Science and Environmental Epidemiology 25 (2015): 381-387.
  17. Centers for Disease Control and Prevention. “Third National Report on human exposure to environmental chemicals”. NCEH Pub. No. 05-570. (2005).
  18. Aguilera-Aguirre L., et al. “Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation”. American Journal of Physiology-Lung Cellular and Molecular Physiology 313 (2017): L1058-L1068.
  19. Golebski K., et al. “Childhood asthma in the new omics era: challenges and perspectives”. Current Opinion in Allergy and Clinical Immunology 2 (2020): 155-161.
  20. Breiteneder H., et al. “Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma”. Allergy 75 (2020): 3039-3068.
  21. Barber D., et al. “Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes”. Asia Pacific Allergy4 (2019):e37.
  22. Eguiluz-Gracia I., et al. “Recent developments and highlights in biomarkers in allergic diseases and asthma”. Allergy 73 (2018): 2290-2305.
  23. Tiotiu A. “Biomarkers in asthma: state of the art”. Asthma Research and Practice 4 (2018):10.
  24. Weidner J., et al. “Spotlight on microRNAs in allergy and asthma”. Allergy 76 (2021): 1661-1678.
  25. Specjalski K and Jassem E. “MicroRNAs: potential biomarkers and targets of therapy in allergic diseases?” Archivum Immunologiae et Therapiae Experimentalis 67 (2019): 213-223.
  26. Quirce S and Bernstein JA. “Old and new causes of occupational asthma”. Immunology and Allergy Clinics of North America 3 (2011): 677-698.
  27. Miedinger D., et al. “Malt can cause both occupational asthma and allergic alveolitis”. Allergy 64 (2009): 1228-1229.
  28. Jeebhay MF and Quirce S. “Occupational asthma in the developing and industrialised world: a review”. International Journal of Tuberculosis and Lung Disease 11.2 (2007): 122-133.
  29. Kogevinas M., et al. “Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II)”. Lancet9584 (2007): 336-341.
  30. Pesonen M., et al. “Occupational allergic contact dermatitis caused by colophonium”. Contact Dermatitis 80 (2019): 9-17.
  31. Lipińska-Ojrzanowska A., et al. “Usefulness of biomarkers in work-related airway disease”. Current Treatment Options in Allergy 4 (2017): 181-190.

Citation

Citation: Maria Concetta D’Ovidio., et al. “The Need of Integrated Tools for the Study of Occupational Exposure to Allergens”.Acta Scientific Medical Sciences 6.2 (2022): 108-118.

Copyright

Copyright: © 2022 Maria Concetta D’Ovidio., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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