Akretche N¹* and Nemmar R²

¹Department of Physical Medicine and Rehabilitation, CHU Mustapha Alger Center, Algeria
²Orthopedic Surgery Department, CHU Mustapha Alger Center, Algeria

*Corresponding Author: Akretche N, Department of Physical Medicine and Rehabilitation, CHU Mustapha Alger Center, Algeria.

Received: December 27, 2021; Published: May 27, 2022

Abstract

Hemophilia is a hematological disease responsible for hemarthrosis starting from the age of learning to walk. In severe forms, these hemarthrosis are at the origin of hemophilic arthropathy that can lead to a loss of autonomy. The clinical and radiological evaluation of this arthropathy must be supplemented by a functional evaluation which will determine the impact of the disorders on the performance of activities of daily living and guide the therapeutic decision. The aim of the present work was to evaluate hemophilic joints clinically, radiologically, and functionally in patients with hemophilic arthropathy.

Our study concerned 43 patients with mean age of 9.17 +/-6.26 a total of 67 affected joints were assessed clinically by the Pednet score, radiologically by the Pettersson score and the functional FISH score. The knees are the most common joints followed by the eblows and ankles. There was a highly significant correlation between Pednet clinical score and Pettersson radiological score (P<0.00001, r = 0.769) and between Pednet clinical score and FISH functional score (r = 0.03 and P = 0.023).Given the signifiant correlation between these scores,these scores can be extremely useful in clinical practice to detect early joint damage and guide therapeutic management.

Keywords: Hemophilia; Hemophilic Arthropathy; Orthopedic Score; Radiological Score; FISH Score

References

1. Lobet S., et al. “Optimal management of hemophilic arthropathy and Hematomas”. Journal of Blood Medicine 5 (2014): 205-207.
2. Rodrigues-Mechan E. “Effects of Haemophilia on Articulations of Children and Adults”. Clinical Orthopaedics and Related Research 328 (1996): 7-13.
3. Alcalay M and Deplas A. “Rheumatological management of patients with hemophilia. Part 1: joint manifestations”. Joint Bone Spine5 (2002): 442-449.
4. Rodriguez-Merchan EC. “End-stage haemophilic arthropathy of the ankle: ankle fusion or total ankle replacement”. Haemophilia1 (2014): 106-107.
5. Sonata Saulyte Trakymien. “Musculoskeletal Pathologies in children with Haemophilia Evaluated using a Standardised Physical Joint Scoring System to Assess Disability”. European Oncology and Haematology (2011): 76-80.
6. Feldman BM., et al. “Musculoskelatal measurement took from the international prophylaxis study group (ipsg)”. Haemophilia 3 (2008): 162-169.
7. Kilcoyne RF and Nuss R. “Radiological evaluation of hemophilic arthropathy”. Seminars in Thrombosis and Hemostasis 1 (2003): 43-48.
8. Kerr R. “Imaging of musculoskeletal complications of hemophilia”. Seminars in Musculoskeletal Radiology 2 (2003): 127-136.
9. Saulyte Trakymiene S., et al. “Progression of haemophilic arthropathy in children: a Lithuanian – Danish comparative study”. Haemophilia2 (2013): 212-218.
10. Poonnoose PM., et al. “Psychometric analysis of the functional 10. Independence score in haemophilia (FISH)”. Haemophilia5 (2007): 620-626.
11. Pollmann H., et al. “When are children diagnosed a shaving severe haemophilia and when do they start to bleed? A 10-year single-entre PUP study”. European Journal of Pediatrics 158 (1999): S166-170.
12. Abdel Ghany H M., et al. “Hemophilic arthropathy: clinical, radiologic, and functional evaluation: a single-center experience in a limited resource country”. Egyptian Reumatologie Rehabilitation 43 (2016): 35-40.
13. Jansen N., et al. “Understanding haemophilic arthropathy: an exploration of current open issues”. British Journal of Haemotology 143 (2008): 632-640.
14. Berntorp E., et al. “Consensus perspectives on prophylactic therapy for haemophilia: summary statement”. Haemophilia (2003): 1-4.
15. Hassan TH., et al. “Correlation between musculoskeletal function and radiological joint scores in haemophilia A adolescents”. Haemophilia6 (2011): 920-925.
16. Van Dijk K., et al. “Variability in the clinical phenotype of severe hemophilia: the role of the first joint bleed”. Haemophilia5 (2005): 438-443.
17. Tlacuilo-Parra A., et al. “Functional independence score inhaemophilia: a cross sectional study assessment of Mexican children”. Pediatric Blood Cancer3 (2010): 348–349.

Citation

Citation: Akretche N and Nemmar R. “Evaluation of Hemophilic Arthropathy in Children in Algiers Center”.Acta Scientific Medical Sciences 6.6 (2022): 269-276.

Copyright

Copyright: © 2022 Akretche N and Nemmar R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.