Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Review Article Volume 6 Issue 2

The Key Aspects of BRCA1 Interactome for Novel Breast Cancer Therapies

Raji Sundararajan* and Ignacio G Camarillo

Purdue University, West Lafayette, USA

*Corresponding Author: Raji Sundararajan, Purdue University, West Lafayette, USA

Received: November 30, 2021; Published: January 12, 2022


In Feb 2021, World Health Organization (WHO) announced that breast cancer overtook lung cancer as the #1 cancer in the world. With over 2 million new cases and over 600,000 deaths in 2020, breast cancer is the most common cancer of women worldwide. About 10% of the breast cancer is familial (or hereditary), caused by mutations of Breast Cancer Susceptibility gene 1, commonly known as BRCA1. Located in chromosome 17, this gene has multiple functions, interactions, pathways and direct and indirect binding partners, contributing to the various hall marks of cancer, including cell cycle and other. It interacts with several genes and proteins and these interactions are studied using String diagrams. The goal is to obtain better insights of the various key aspects of these interactions and utilize them towards novel breast cancer therapies for familial breast cancer treatments.

Keywords: BRCA1; Breast Cancer; Familial; String Diagram; Gene Ontology; Pathways


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Citation: Raji Sundararajan and Ignacio G Camarillo., et al. “The Neonates' Body Length and Body Weight in Two Different Periods of Time”.Acta Scientific Medical Sciences 6.2 (2022): 65-73.


Copyright: © 2022 Raji Sundararajan and Ignacio G Camarillo., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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