COVID-19 Severity and Serum Level of Procalcitonin: A Systematic Review
Mohamed Awny Abdelhamid Abouhemda*
Mabarat El Maadi Hospital, El Maadi, Cairo, Egypt
*Corresponding Author: Mohamed Awny Abdelhamid Abouhemda, Mabarat El Maadi Hospital, El Maadi, Cairo, Egypt.
November 29, 2021; Published: December 23, 2021
Objective: To review the serum level of procalcitonin in relation to COVID-19 severity.
Data Sources: All articles published between 2003 and 2021 were subjected to a comprehensive search of MEDLINE (PubMed, Medscape, Science Direct, EMF-Portal) and the Internet.
Study Selection: English-language reports of procalcitonin and COVID-19 were chosen for this study. The initial search yielded 127 articles, 51 of which met the requirements for inclusion.
Data Extraction: Articles that did not include procalcitonin or COVID-19 in the title or abstract were excluded from the study. Data on methodology was collected by 26 independent investigators.
Data Synthesis: Structured reviews were used to make comparisons, with the results tallied. COVID-19 mortality-related risk factors have been studied in 21 studies, while PCT level has been studied in 30 studies in relation to COVID-19 severity.
Findings: As of 2020, Egypt's total number of COVID-19 patients is predicted to be in the range of 710–5241 patients. Dyspnea, diabetes mellitus, lymphopenia, elevated CRP, ESR, ferritin, ALT, AST, low albumin, increased D-dimer, and the presence of CT chest abnormalities might all be used as predictors for COVID-19 severity. Most prior investigations discovered a statistically highly significant relationship between serum procalcitonin levels and COVID-19 severity (p0.001).
Conclusion: Demographic, clinical, haematological, biochemical, and imaging data, as well as dyspnea, diabetes mellitus, obesity, smoking, lymphopenia, elevated CRP, ESR, ferritin, ALT, AST, low albumin, increased D-dimer, and the presence of CT chest findings, were found to be predictors of COVID-19 severity in this study. These aspects should be given extra attention, and more evaluations should be done to look into the underlying processes of these effects. PCT may also serve as a predictor of disease severity and aid in identifying the severity of COVID-19 patients. Serial PCT measurements may also be helpful in predicting prognosis. Additional research is needed to better understand the methods by which more PCT is produced and released in SARSCoV-2 patients.
Keywords: Covid-19; Procalcitonin; Mortality Risk; Egyptian Patients; Severity Disease
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