Inhibitory Effect of Foeniculum Vulgare Leaf Extract on Alpha-glucosidase
and Alpha-amylase Activity
Gomaa F Salma*
1Department of Medical Lab Technology, School of Medical and Allied Sciences, Galgotias University, India
2Division of Life Sciences, School of Basic and Applied Sciences, Galgotias University, India
*Corresponding Author: Mythily Subramaneyaan, Division of Life Sciences, School of Basic and Applied Sciences, Galgotias University, India.
August 25, 2021; Published: December 06, 2021
Diabetes mellitus is a chronic disease with a tremendous global incidence. Inhibition of carbohydrates digesting enzymes (α-amylase and α-glucosidase) retards glucose absorption thereby attenuates hyperglycemia is one of many approaches used for the management of this disease. The present study is aimed to analyse the inhibitory effect of ethanolic extract of Foeniculum vulgare (FV) on α-amylase and α-glucosidase and its phytochemical screening. Phytochemical analysis of ethanol extract of Foeniculum vulgare showed major classes of secondary metabolites namely flavonoid, steroid, alkaloid, saponin, triterpenoid, quinone, tannins, coumarin, and phenol. The ethanolic extract of FV exhibited inhibition of α-amylase and α-glucosidase by 87.14% in and 85.20% at 1000 µg/ml, this might be due to phytochemicals/secondary metabolites. The results of the present study prove that the ethanolic extracts of FV were effective in inhibiting α-amylase and α-glucosidase activity that might lead to the reduction of glucose levels. The results of this study suggest that the ethanolic extract of FV might be potent antidiabetic.
Keywords: Foeniculum vulgare; Secondary Metabolites; Alpha Amylase; Alpha Glucosidase; Type 2 Diabetes Mellitus; Anti-diabetic Activity
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