Jomaa Olfa¹*, Jguirim Mahbouba¹, Rim Klii², Ardhaoui Mahbouba¹, Bejia Ismail¹, Touzi Monji¹, Bergaoui Naceur¹

¹Department of Rheumatology, University of Monastir, Fattouma Bourguiba Hospital, Tunisia
²Department of Internal Medicine, University of Monastir, Fattouma Bourguiba Hospital, Tunisia

*Corresponding Author: Jomaa Olfa, Department of Rheumatology, University of Monastir, Fattouma Bourguiba Hospital, Tunisia.

Received: August 30, 2021; Published: September 18, 2021

Abstract

  Bisphosphonates are structural analogues of inorganic pyrophosphate that are potent inhibitors of bone resorption. In pediatric rheumatology, the main indications of bisphosphonates are primary osteoporosis as idiopathic juvenile osteoporosis, osteogenesisimperfecta, osteoporosis secondary to chronic rheumatological, endocrine, immobilization, or gastrointestinal disorders, tissucalcinosis and dermatomyosistis.

  Several pediatric studies have been conducted, mainly in osteogenesis imperfecta and chronic rheumatic diseases. The results obtained with bisphosphonates, especially with pamidronate and alendronate were promising. The use of bisphosphonates should be reserved for children severely affected by a symptomatic osteoporosis. These children should be included in clinical studies with long term monitoring. The regimens reported were cyclic infusion of pamidronate at 0,5 to 1 mg/kg/dose with a cumulative dose not exceeding 9 mg/kg/year. The dose suggested for alendronate were 5 mg once daily or 35 mg once a week for children less than 30 kg and 10 mg once daily or 70 mg once weekly for more than 30 kg. Treatment protocols must be defined especially with recent bisphosphonates, particularly effectives.

  Suppose efficacy and tolerability of bisphosphonates in short terms are encouraging. In that case, the duration of treatment and the long-term toxicity, especially in subsequent pregnancies, require further studies.

Keywords: Osteoporosis; Osteogenesisimperfecta; Children; Bisphosphonates; Pediatric DXA; Pamidronate

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Citation

Citation: Jomaa Olfa., et al. “Bisphosphonate Use in Childhood”.Acta Scientific Medical Sciences 5.10 (2021): 82-91.

Copyright

Copyright: © 2021 Jomaa Olfa., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.