L Ratiani1,2, T Sanikidze2, G Ormotsadze2,3, E Vashakidze1,2, V Shoshiashvili1,2*, E Pachkoria1,2, M Rurua1,2, E Khuchua1,2, L Gabunia1,2, K Machavariani1,2 and T Megrelishvili1,2
1First University Clinic of Tbilisi State Medical University, Georgia
2Tbilisi State Medical University, Georgia
3I. Beritashvili Center of Experimental Biomedicine, Georgia
*Corresponding Author: V Shoshiashvili, First University Clinic of Tbilisi State Medical University, Georgia.
Received: July 16, 2021; Published: August 28, 2021
The number of patients with COVID-19 is currently rapidly increasing globally. Most of the patients with COVID-19 have a favorable prognosis, but some have rapidly progressed to severe and critical conditions with respiratory distress syndrome, coagulation dysfunction, multiple organ failure, etc.
The purpose of our study was to identify early clinical-laboratory indicators of possible complications in COVID-19 patients.
The information of a total of 106 patients with confirmed COVID-19 (the positive result of the nucleic acid test by real-time fluorescence RT-PCR), who were admitted to First University Clinic of Tbilisi State Medical University (Georgia) (1.04.20-1.5.20), was collected. The clinical-laboratory data (saturation index, pH, hemoglobin, leukocytes (lymphocytes and neutrophils) and thrombocytes content, prothrombin, D-Dimer, CRP, LDH, AST, ALT, bilirubin, urea level in the blood, and CT-rate) were collected at the time of patient admission to the hospital.
In accordance with the severity of the course of the disease during hospitalization, all patients were divided into two groups - without complications and with severe complications, when respiratory and other organs failure occur, requiring observation and treatment in intensive care units (ICU).
Exploratory and confirmatory (K-mean Clustering, ANOVA, Xi2), data analysis methods were used to reveal the statistical reliability of the difference between the mean values of the parameters. To identify the optimal complex predictors of the risk of complications, Binary Logistic Regression analysis and Receiver operating characteristic (ROC) curve analysis were performed.
According to the results of the study, it was found that the prognostic criterion of further complications in patients with COVID-19, developed on the basis of a linear function of parameter values (saturation index, neutrophil count, and CT-Rate) at the moment of hospitalization is characterized by high accuracy. Also, the ways for further refining the complex prognostic criterion were identified. In particular, the use of generalized nonlinear models with random effects in regression will allow to 1) increase the number of clinical- laboratory characteristics, 2) consider the effects of interaction between them, 3) to assess the level of uncertainty and its sources.
The studied cohort was quite limited (106 patients) and given the importance of comorbidities in the development of complications of COVID-19, it is unlikely to be representative of the general population. It is important to increase the studied cohort's capacity, which will allow us to take into account the effects of comorbidity, the degree of representativeness, and perform a comparative analysis of various therapeutic approaches, generalize the results to other populations.
Keywords: COVID -19; Clinical-laboratory; Indicators; Complication; Predictor
Citation: V Shoshiashvili., et al. “The Informative Value of Several Clinical-laboratory Characteristics at the Time of Hospitalization in Terms of Prognosis of Disease Complication with COVID-19 Patients”.Acta Scientific Medical Sciences 5.9 (2021): 143-149.
Copyright: © 2021 V Shoshiashvili., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.