Isabella Maria Rocha Fidalgo dos Reis Maluf1, Andrezza Melo Vianna1, Pâmela Pontes Penas Amado1, Priscila Larcher Longo2 and Rômulo Tadeu Dias de Oliveira3*
1University Center of Americas, São Paulo, Brazil
2Aging Science Program, São Judas Tadeu University, São Paulo, Brazil
33University of Sorocaba, São Paulo, Brazil
*Corresponding Author: Rômulo Tadeu Dias de Oliveira, University of Sorocaba, São Paulo, Brazil.
Received: August 20, 2020; Published: September 26, 2020
Multiple sclerosis (MS) is a chronic autoimmune disease of central nervous system which etiology remains unclear. Worldwide studies suggest strong link between vitamin D deficiency and MS. In this study, we conducted a systematic literature search regarding the effect of high dose vitamin D treatment in immunological parameters of MS patients. High dose vitamin D treatment promotes few significant chances in immunological systemic markers, mainly in the total amount of peripheral blood IL-17+CD4+ T cells and in the proportion of TH IL-4+ cells. In summary, high dose treatment promotes limited differences in immunological markers in patients with MS.
Keywords: Multiple Sclerosis; Vitamin D; Treatment; Systematic Review; Supplementation
Citation: Rômulo Tadeu Dias de Oliveira., et al. “Influence of High Doses Vitamin D Therapy at Immunological Parameters in Multiple Sclerosis Patients. A Systematic Review". Acta Scientific Medical Sciences 3.10 (2020): 164-175.
Copyright: © 2020 Rômulo Tadeu Dias de Oliveira., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.