Acta Scientific Medical Sciences (ASMS)(ISSN: 2582-0931)

Research Article Volume 4 Issue 10

Influence of High Doses Vitamin D Therapy at Immunological Parameters in Multiple Sclerosis Patients. A Systematic Review

Isabella Maria Rocha Fidalgo dos Reis Maluf1, Andrezza Melo Vianna1, Pâmela Pontes Penas Amado1, Priscila Larcher Longo2 and Rômulo Tadeu Dias de Oliveira3*

1University Center of Americas, São Paulo, Brazil
2Aging Science Program, São Judas Tadeu University, São Paulo, Brazil
33University of Sorocaba, São Paulo, Brazil

*Corresponding Author: Rômulo Tadeu Dias de Oliveira, University of Sorocaba, São Paulo, Brazil.

Received: August 20, 2020; Published: September 26, 2020



  Multiple sclerosis (MS) is a chronic autoimmune disease of central nervous system which etiology remains unclear. Worldwide studies suggest strong link between vitamin D deficiency and MS. In this study, we conducted a systematic literature search regarding the effect of high dose vitamin D treatment in immunological parameters of MS patients. High dose vitamin D treatment promotes few significant chances in immunological systemic markers, mainly in the total amount of peripheral blood IL-17+CD4+ T cells and in the proportion of TH IL-4+ cells. In summary, high dose treatment promotes limited differences in immunological markers in patients with MS.

Keywords: Multiple Sclerosis; Vitamin D; Treatment; Systematic Review; Supplementation



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Citation: Rômulo Tadeu Dias de Oliveira., et al. “Influence of High Doses Vitamin D Therapy at Immunological Parameters in Multiple Sclerosis Patients. A Systematic Review". Acta Scientific Medical Sciences 3.10 (2020): 164-175.


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