Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 5

A Benign Giant Prostate Hyperplasia Causing Fatal Death without any Prior Symptomatology, a Rare Case Study

Juna Musa1*, Elton Cekaj2, Mohammed K Badi3, Carlos Rivera4, Edlira Horjeti5, Henri Fero6, Loran Rakovica7 and Ali Guy8

1Postdoctoral Research Fellow, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
2Radiologist, Regional Hospital of Durres, Albania
3Research Fellow, Department of Neurology, Mayo Clinic, Florida, USA
4Research Fellow, General Surgery Department, Metabolic and Bariatric Institute, Cleveland Clinic, Florida, USA
5Family Doctor, Department of Family Medicine, Tirane, Albania
6Medical Student, Faculty of Medicine, Univeriteti of Tirana, Albania
7Faculty of Medicine, University of Prishtina, Kosovo
8Department of Physical Medicine and Rehabilitation, New York University, School of Medicine, NYU Medical Center, New York, USA

*Corresponding Author: Juna Musa, Postdoctoral Research Fellow, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Received: March 31, 2020; Published: April 08, 2020



  Benign Prostatic Hyperplasia (BPH) is a common progressive disease of ageing men that is characterized prostate enlargement leading to lower urinary tract symptoms. Prostate volume have been shown to directly correlate with age, men over the age of 50 have a 40% risk of BPH and those over 80 years have 90% risk. Giant prostatic hyperplasia (GPH) is a rare form of BPH and it is commonly seen in patients neglecting their symptoms or inadequately treated disease. BPH symptoms vary with the grade of the disease ranging from asymptomatic to incontinence, nocturia, hematuria, dysuria and urinary retention in more severe forms such as in GPH. Herein we present a case of a 53 years old male patient that presented with altered mental status, pale skin and urinary retention. During the ultrasound examination a huge prostate gland was discovered.

Keywords: Benign Prostatic Hyperplasia (BPH); Giant Prostatic Hyperplasia (GPH); Fatal Death



  1. Paul Martin and Hassan Resvi. “Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS) in Men”.
  2. McNeal JE. “The prostate gland. Morphology and pathobiology”. Monograph Urology 4 (1983): 5-13.
  3. Berry SJ., et al. “The development of human benign prostatic hyperplasia with age”. The Journal of Urology 132 (1984): 474-479.
  4. Maio A and Rifkin MD. “Magnetic resonance imaging of prostate cancer: Update”. Topics in Magnetic Resonance Imaging 7 (1995): 54-68.
  5. Dennis MA and Donohue RE. “Computed tomography of prostatic abscess”. Journal of Computer Assisted Tomography 9 (1985): 201-202.
  6. Ling D., et al. “Prostatic carcinoma and benign prostatic hyperplasia: Inability of MR imaging to distinguish between the two diseases”. Radiology 158 (1986): 103-107.
  7. Schiebler ML., et al. “Prostatic carcinoma and benign prostatic hyperplasia: Correlation of high-resolution MR and histopathologic findings”. Radiology 172 (1989): 131-137.
  8. Shivadeo S Bapat., et al. “Does estimation of prostate volume by abdominal ultrasonography vary with bladder volume: A prospective study with transrectal ultrasonography as a reference”. Indian Journal of Urology4 (2006): 322-325.
  9. E Akpo and M Akpo. “Giant Benign Prostatic Hyperplasia in A Nigerian: Report of A Case”. The Internet Journal of Urology 8 (2010): 1.
  10. Joseph Maliakal., et al. “Giant Prostatic Hyperplasia Fourth largest prostate reported in medical literature”. Sultan Qaboos University Medical Journal 14-2 (2014): 253-256.
  11. Coakley F V and Hricak H. “Radiologic Anatomy of The Prostate Gland: A Clinical Approach”. Radiologic Clinics of North America 1 (2000): 15-30.
  12. Aghamir SMK., et al. “Giant benign prostatic hyperplasia: A case report”. Urology Case Reports (2019): 101051.
  13. Kava B., et al. “Prostate Artery Embolization for Giant Prostatic Hyperplasia”. Journal of Vascular and Interventional Radiology10 (2019): 1583-1585.
  14. De Assis AM., et al. “Prostatic Artery Embolization for Treatment of Benign Prostatic Hyperplasia in Patients with Prostates and gt; 90 g: A Prospective Single-Center Study”. Journal of Vascular and Interventional Radiology 1 (2015): 87-93.
  15. Mathevosian S., et al. “Prostate Artery Embolization for Giant Prostatic Enlargement: Short-Term Efficacy and Safety”. Journal of Vascular and Interventional Radiology 11 (2019): 1820-1823.
  16. Domínguez A., et al. “Giant prostatic hyperplasia: Case report of 3987 mL”. Urology 88 (2016): e3-e4.
  17. Wei JT., et al. “Urologic diseases in America project: Benign prostatic hyperplasia”. The Journal of Urology 4 (2005): 1256-1261.
  18. Isaacs JT. “Antagonistic effect of androgen on prostatic cell death”. Prostate5 (1984): 545-557.
  19. Robert G., et al. “Inflammation in benign prostatic hyperplasia: A 282 patients’ immunohistochemical analysis”. Prostate16 (2009): 1774-1780.
  20. Lei YMK., et al. “Association of Variants in Genes Related to the Immune Response and Obesity with Benign Prostatic Hyperplasia in CLUE II”. Clinics and Research in Hepatology and Gastroenterology 1 (2015): 919.
  21. Lee SH., et al. “Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population”. Genetics and Molecular Research 4 (2015): 18607-18615.


Citation: Juna Musa., et al. “A Benign Giant Prostate Hyperplasia Causing Fatal Death Without any Prior Symptomatology, a Rare Case Study". Acta Scientific Medical Sciences 4.5 (2020): 14-17.


Acceptance rate30%
Acceptance to publication20-30 days
Impact Factor1.403

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US