Wafaa Mohamed El Sehly1*, Rania Abd Elmeguid Ahmed2, Jiddaa Farouk Mekky3, Karim Mahmoud Nabil4 and Magda Hassan5
1Professor of Forensic Medicine and Clinical Toxicology, Faculty of Medicine University of Alexandria, Egypt
2Lecturer in Forensic Medicine and Clinical Toxicology, Faculty of Medicine University of Alexandria, Egypt
3Lecturer in Neuropsychiatry, Faculty of Medicine University of Alexandria, Egypt
4Lecturer in Ophthalmology, Faculty of Medicine University of Alexandria, Egypt
5Assistant Lecturer of Forensic Medicine and Clinical Toxicology, Faculty of Medicine University of Alexandria, Egypt
*Corresponding Author: Wafaa Mohamed El Sehly, Professor of Forensic Medicine and Clinical Toxicology, Faculty of Medicine University of Alexandria, Egypt.
Received: December 27, 2019; Published: March 17, 2020
' Psychotic disorders are severe mental disorders that cause abnormal thinking and perceptions. People with psychoses lose touch with reality. Two of the main symptoms are delusions and hallucinations. Antipsychotic drug treatment is a key component of schizophrenia treatment. First-generation antipsychotics, known as typical antipsychotics, neuroleptics or major tranquilizers. Most second-generation drugs, known as atypical antipsychotics, have been developed more recently. All psychotropic medications have the potential to induce numerous and diverse unwanted ocular effects. Psychiatrists, ophthalmologists and patients need to be aware of and prepared for any medication-induced toxic effect. Early prevention and intervention can avoid most of the serious and potentially irreversible ocular toxicities.
' The aims of the present study were to assess the occurrence of toxic ocular effects of antipsychotic drugs, evaluate intraocular pressure of chronic psychotic patients treated with psychiatric medications, Correlate toxic ocular effects in patients treated with a variety of antipsychotics to duration of treatment and detect early toxic ocular effects for early intervention. Informed consent will be taken from patients. The present study was conducted on 100 chronic psychotic patients attending the Alexandria main university hospital who on treatment of antipsychotic drugs for a period more than six months period with age group between18 - 60 years.14% of those patients were on typical therapy alone,16% on atypical antipsychotic alone while 70% were on combined therapy. 2% of all cases had pigmentation of conjunctiva all were on typical therapy. Corneal opacity was manifested on 4% of all cases. All of them was on typical therapy. As regard lens opacity, 7% was suffered from lens opacity, six cases due to typical therapy while one cases due to atypical therapy. intraocular pressure was manifested in 11% of all cases. Optic examination revealed two cases had increased cup disc ratio who on typical therapy alone. So, it was concluded that ocular toxicity was manifested mainly with typical therapy that affected by duration of treatment. the incidence of toxicity decreased with atypical or combination of typical and atypical.
Keywords: Pattern of Ocular; Toxicity in Patients; Antipsychotic; Therapy at Alexandria
Citation: Wafaa Mohamed El Sehly., et al. “Pattern of Ocular Toxicity in Patients on Antipsychotic Drug Therapy at Alexandria Main University Hospital". Acta Scientific Medical Sciences 4.4 (2020): 69-77.
Copyright: © 2020 Wafaa Mohamed El Sehly., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.