András Sikter MD*
Internal Medicine, Municipal Clinic of Szentendre, Szentendre, Hungary, Europe
*Corresponding Author: András Sikter MD, Internal Medicine, Municipal Clinic of Szentendre, Szentendre, Hungary, Europe. E-mail: firstname.lastname@example.org
Received: February 17, 2020; Published: February 29, 2020
According to the hypothesis of the author, the Metabolic Syndrome and Type 2 Diabetes are mainly consequences of chronic low-grade hypercapnia and related intracellular acidosis. The altered pCO2 status changes the Intracellular Ion-Pattern and, consequently, the metabolism. The author has developed a recovery strategy based on his metabolic model, experiences, and data of literature. The primary goal is to increase the minute-ventilation to achieve low-grade hypocapnia (~ 35 mmHg on average) and to maintain it in the long run. As a consequence of the decreased pCO2 level - according to the hypothesis - an intracellular alkaline pH develops and results in increased metabolism, ATP production, and consequently, phosphate, Mg2+, K+, and Zn2+ influx into the cytosol. Serum Ca2+ levels may also decrease due to increased calcium and phosphate uptake into the 'hungry bones.' It is expected that both the carbohydrates and fats will be burned more intensively in mitochondria, which would also mean a decrease in insulin resistance, serum glucose, and lipid levels. The essence of the method is that regular daily administration of monobasic phosphate (H2PO4-) salts as fixed acids can increase respiratory minute volume and decrease the pCO2 level. It is advised to give these salts routinely in doses below the Recommended Dietary Allowance. After achieving the desired pCO2 level, it is advocated that an acidotic H2PO4-/ HPO42- salt mixture be titrated to maintain the low-grade hypocapnia. Preferably, the cations are provided by combinations of Mg2+, K+, and Ca2+. The amounts of ions to be administered can be determined by monitoring serum electrolytes. According to the hypothesis, this method could be particularly useful in diseases where elevated levels of pCO2 play a pathophysiological role.
The author also proposes an improved method of Sodi-Pallarés; alternatively, it can be an infusion containing the combination of phosphate buffer, K+, Mg2+, Zn2+, and (possibly) other 'cytoplasm-builder' nutrients plus glucose and insulin. Theoretically, it could improve the metabolism of the chronically ill or insulin-resistant patients.
Keywords: Healing with Ion-Mixture Compositions; HPO42- as the Second Messenger of Insulin; Modified Method of Sodi-Pallarés; Momentary Intracellular Ion-Pattern Signaling
Citation: András Sikter. “Psychosomatic Molecular Mechanisms of Metabolic Syndrome and Type 2 Diabetes. Part 4. A Recovery Strategy from Chronic Hypercapnia and Metabolic Syndrome-Related Disorders, (a Research Proposal). Acta Scientific Medical Sciences 4.3 (2020): A41-A52.
Copyright: © 2020 András Sikter. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.