Abstract

  According to the hypothesis of the author, the Metabolic Syndrome and Type 2 Diabetes are mainly consequences of chronic low-grade hypercapnia and related intracellular acidosis. The altered pCO₂ status changes the Intracellular Ion-Pattern and, consequently, the metabolism. The author has developed a recovery strategy based on his metabolic model, experiences, and data of literature. The primary goal is to increase the minute-ventilation to achieve low-grade hypocapnia (~ 35 mmHg on average) and to maintain it in the long run. As a consequence of the decreased pCO₂ level - according to the hypothesis - an intracellular alkaline pH develops and results in increased metabolism, ATP production, and consequently, phosphate, Mg²⁺, K⁺, and Zn²⁺ influx into the cytosol. Serum Ca²⁺ levels may also decrease due to increased calcium and phosphate uptake into the 'hungry bones.' It is expected that both the carbohydrates and fats will be burned more intensively in mitochondria, which would also mean a decrease in insulin resistance, serum glucose, and lipid levels. The essence of the method is that regular daily administration of monobasic phosphate (H₂PO₄^-) salts as fixed acids can increase respiratory minute volume and decrease the pCO₂ level. It is advised to give these salts routinely in doses below the Recommended Dietary Allowance. After achieving the desired pCO₂ level, it is advocated that an acidotic H₂PO₄^-/ HPO₄^2- salt mixture be titrated to maintain the low-grade hypocapnia. Preferably, the cations are provided by combinations of Mg²⁺, K⁺, and Ca²⁺. The amounts of ions to be administered can be determined by monitoring serum electrolytes. According to the hypothesis, this method could be particularly useful in diseases where elevated levels of pCO₂ play a pathophysiological role.

  The author also proposes an improved method of Sodi-Pallarés; alternatively, it can be an infusion containing the combination of phosphate buffer, K⁺, Mg²⁺, Zn²⁺, and (possibly) other 'cytoplasm-builder' nutrients plus glucose and insulin. Theoretically, it could improve the metabolism of the chronically ill or insulin-resistant patients.

Keywords: Healing with Ion-Mixture Compositions; HPO₄^2- as the Second Messenger of Insulin; Modified Method of Sodi-Pallarés; Momentary Intracellular Ion-Pattern Signaling

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Citation

Citation: András Sikter. “Psychosomatic Molecular Mechanisms of Metabolic Syndrome and Type 2 Diabetes. Part 4. A Recovery Strategy from Chronic Hypercapnia and Metabolic Syndrome-Related Disorders, (a Research Proposal). Acta Scientific Medical Sciences 4.3 (2020): 150-161.

Copyright

Copyright: © 2020 András Sikter. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.