Acta Scientific Medical Sciences (ISSN: 2582-0931)

Research Article Volume 4 Issue 3

Preliminary Study of Prostatic Fluid Levels of Zinc Concentration as the Biodosimeter of Males Exposure to Ionizing Radiation

Vladimir Zaichick1* and Sofia Zaichick2

1Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, Russia
2Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, Chicago, USA

*Corresponding Author: Vladimir Zaichick, Radionuclide Diagnostics Department, Medical Radiological Research Centre, Obninsk, Russia.

Received: January 17, 2020; Published: February 08, 2020

×

Abstract

  Among different bio dosimeters, there is a need in methods that can rapidly and accurately determine individual exposure to ionizing radiation during examination a big cohort of people, particularly men. In present study contents of trace elements in the prostatic fluid were investigated to search for a new biological dosimeter. Prostatic fluid samples were obtained from 15 men aged 38 - 77 years suffering from bladder cancer. All patients were treated with external (distant) gamma-ray therapy. Fractionated tumour irradiation was used with a total dose of 65 Gy. The tumour was daily irradiated with the dose ranged from 6 to 12 Gy. The prostate radiation dose was calculated according to the distribution of isodose levels within patient’s body during the simulation of external local gamma-ray irradiation of bladder tumour. Transrectal digital massage was used to obtain expressed prostatic fluid samples before and 2 - 4 times during radiation therapy for the energy dispersive X-ray fluorescent analysis. A day after the first irradiation of the prostate with the average dose 4.6 Gy to prostate concentration of zinc in the prostatic fluid was about three times lower the metal level before gamma-ray therapy. The dose detection threshold was calculated up to 0.1 Gy. The exponential function was the best for approximation the “dose-effect” dependence of the zinc level in prostatic fluid from the radiation exposure during external gamma-ray therapy of patients with bladder cancer.

Keywords: Prostate; Prostatic Fluid; Biomarkers; Trace Elements; Zinc; Biological Dosimetry

×

References

  1. Swartz HM., et al. “Overview of the principles and practice of biodosimetry”. Radiation and Environmental Biophysics 53.2 (2014): 221-232. 
  2. Bhat NN., et al. “Biodosimetry techniques and the biological indicators of radiation exposure in humans”. BARC Newsletter 365 (2018): 22-30.
  3. He X., et al. “Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method”. Radiatation Protection Dosimetry 159.1-4 (2014): 172-181.
  4. Ryan TI., et al. “Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects”. PLoS One 14.5 (2019): e0216081.
  5. Zaichick V., et al. “Zinc in the human prostate gland: normal, hyperplastic and cancerous”. International Urology and Nephrology 29.5 (1997): 565-574.
  6. Zaichick V. “INAA and EDXRF applications in the age dynamics assessment of Zn content and distribution in the normal human prostate”. Journal of Radioanalytical and Nuclear Chemistry 262 (2004): 229-234.
  7. Zaichick S and Zaichick V. “Method and portable facility for energy-dispersive X-ray fluorescent analysis of zinc content in needle-biopsy specimens of prostate”. X-Ray Spectrometry 39 (2010): 83-89.
  8. Zaichick S and Zaichick V. “INAA application in the age dynamics assessment of Br, Ca, Cl, K, Mg, Mn, and Na content in the normal human prostate”. Journal of Radioanalytical and Nuclear Chemistry (2011): 197-202.
  9. Zaichick S and Zaichick V. “The effect of age on Ag, Co, Cr, Fe, Hg, Sb, Sc, Se, and Zn contents in intact human prostate investigated by neutron activation analysis”. Applied Radiation and Isotopes 69 (2011): 827-833.
  10. Zaichick S and Zaichick V. “The Br, Fe, Rb, Sr, and Zn contents and interrelation in intact and morphologic normal prostate tissue of adult men investigated by energy-dispersive X-ray fluorescent analysis”. X-Ray Spectrometry 40.6 (2011): 464-469.
  11. Zaichick S and Zaichick V. “Trace elements of normal, benign hypertrophic and cancerous tissues of the human prostate gland investigated by neutron activation analysis”. Applied Radiation and Isotopes 70 (2012): 81-87.
  12. Zaichick V., et al. “The effect of age on 12 chemical element contents in intact prostate of adult men investigated by inductively coupled plasma atomic emission spectrometry”. Biological Trace Element Research 147 (2012): 49-58.
  13. Zaichick S., et al. “Mass fractions of 52 trace elements and zinc trace element content ratios in intact human prostates investigated by inductively coupled plasma mass spectrometry”. Biological Trace Element Research 149. 2 (2012): 171-183.
  14. Zaichick S and Zaichick V. “Relations of morphometric parameters to zinc content in paediatric and nonhyperplastic young adult prostate glands”. Andrology 1.1 (2013): 139-146.
  15. Zaichick V and Zaichick S. “The effect of age on Br, Ca, Cl, K, Mg, Mn, and Na mass fraction in pediatric and young adult prostate glands investigated by neutron activation analysis”. Applied Radiation and Isotopes 82 (2013): 145-151. 
  16. Zaichick V and Zaichick S. “INAA application in the assessment of Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn mass fraction in pediatric and young adult prostate glands”. Journal of Radioanalytical and Nuclear Chemistry 298 (2013): 1559-1566. 
  17. Zaichick V and Zaichick S. “NAA-SLR and ICP-AES Application in the assessment of mass fraction of 19 chemical elements in pediatric and young adult prostate glands”. Biological Trace Element Research 156 (2013): 357-366.
  18. Zaichick V and Zaichick S. “Use of neutron activation analysis and inductively coupled plasma mass spectrometry for the determination of trace elements in pediatric and young adult prostate”. American Journal of Analytical Chemistry 4 (2013): 696-706. 
  19. Zaichick V and Zaichick S. “Relations of bromine, iron, rubidium, strontium, and zinc content to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands”. Biological Trace Element Research 157 (2014): 195-204. 
  20. Zaichick V and Zaichick S. “Relations of the neutron activation analysis data to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands”. Advances in Biomedical Science and Engineering 1.1 (2014): 26-42. 
  21. Zaichick V and Zaichick S. “Relations of the Al, B, Ba, Br, Ca, Cl, Cu, Fe, K, Li, Mg, Mn, Na, P, S, Si, Sr, and Zn mass fractions to morphometric parameters in pediatric and nonhyperplastic young adult prostate glands”. Bio Metals 27 (2014): 333-348. 
  22. Zaichick V and Zaichick S. “The distribution of 54 trace elements including zinc in pediatric and nonhyperplastic young adult prostate gland tissues”. Journal of Clinical and Laboratory Investigation Updates 2.1 (2014): 1-15. 
  23. Zaichick V and Zaichick S. “Androgen-dependent chemical elements of prostate gland”. Andrology and Gynecology: Current Research 2 (2014): 2. 
  24. Zaichick V and Zaichick S. “Differences and relationships between morphometric parameters and zinc content in nonhyperplastic and hyperplastic prostate glands”. British Journal of Medicine and Medical Research 8.8 (2015): 692-706.
  25. Zaichick V and Zaichick S. “Trace element levels in prostate gland as carcinoma’s marker”. Journal of Cancer Therapy 8 (2017): 131-145.
  26. Zaichick V and Zaichick S. “Ratios of selected chemical element contents in prostatic tissue as markers of malignancy”. Hematology and Medical Oncology 1.2 (2016): 1-8.
  27. Zaichick V and Zaichick S. “Ratios of Zn/trace element contents in prostate gland as carcinoma’s markers”. Cancer Reports and Reviews 1.1 (2017): 1-7.
  28. Zaichick V and Zaichick S. “Ratios of selenium/trace element contents in prostate gland as carcinoma’s markers”. Journal of Tumor Medicine and Prevention 1.2 (2017): 555-556.
  29. Zaichick V and Zaichick S. “Ratios of rubidium/trace element contents in prostate gland as carcinoma’s markers”. Cancer Research and Clinical Oncology 1.1 (2017):13-21.
  30. Zaichick V and Zaichick S. “Ratios of cadmium/trace element contents in prostate gland as carcinoma’s markers”. Cancer Therapy and Oncology International Journal 4.1 (2017): 555626.
  31. Zaichick V and Zaichick S. “Ratios of cobalt/trace element contents in prostate gland as carcinoma’s markers”. The International Journal of Cancer Epidemiology and Research 1.1 (2017): 21-27. 
  32. Zaichick V and Zaichick S. “Ratios of calcium/trace elements as prostate cancer markers”. Journal of Oncology Research and Therapy 4 (2017): J116.
  33. Zaichick V and Zaichick S. “Ratios of Mg/trace element contents in prostate gland as carcinoma’s markers”. SAJ Cancer Science 2.1 (2017): 102.
  34. Zaichick V and Zaichick S. “Age-related changes in concentration and histological distribution of 54 trace elements in nonhyperplastic prostate of adults”. International Archives of Urology and Complications 2.2 (2016): 019.
  35. Zaichick V and Zaichick S. “Trace element levels in prostate gland as carcinoma’s markers”. Journal of Cancer Therapy 8 (2017): 131-145.
  36. Zaichick V and Zaichick S. “Chemical element contents in normal and benign hyperplastic prostate”. Annals of Men’s Health and Wellness 1.2 (2017): 1006.
  37. Zaichick V. “The variation with age of 67 macro- and microelement contents in nonhyperplastic prostate glands of adult and elderly males investigated by nuclear analytical and related methods”. Biological Trace Element Research 168.1 (2015): 44-60.
  38. Zaichick V. “Differences between 66 chemical element contents in normal and cancerous prostate”. Journal of Analytical Oncology 6.2 (2017): 37-56.
  39. Zaichick V and Zaichick S. “Comparison of 66 chemical element contents in normal and benign hyperplastic prostate”. Asian Journal of Urology 6.3 (2019): 275-289.
  40. Zaichick V. “The prostatic urethra as a Venturi effect urine-jet pump to drain prostatic fluid”. Medical Hypotheses 83 (2014):65-68. 
  41. Mackenzie AR., et al. “Zinc content of expressed human prostate fluid”. Nature (London) 193.4810 (1962): 72-73. 
  42. Marmar JL., et al. “Values for zinc in whole semen, fraction of split ejaculate and expressed prostatic fluid”. Urology 16.5 (1980): 478-480. 
  43. Zaichick V., et al. “Method for diagnostics of prostate diseases”. Certificate of Invention (1981).
  44. Zaichick V., et al. “Zinc concentration in human prostatic fluid: normal, chronic prostatitis, adenoma, and cancer”. International Urology and Nephrology 28.5 (1996): 687-694.
  45. Zaichick V., et al. “Method and portable facility for measurement of trace element concentration in prostate fluid samples using radionuclide-induced energy-dispersive X-ray fluorescent analysis”. Nuclear Science and Technology 27.6 (2016): 1-8. 
  46. Zaichick V and Zaichick S. “Effect of age on the Br, Fe, Rb, Sr, and Zn concentrations in human prostatic fluid investigated by energy-dispersive X-ray fluorescent microanalysis”. Micro Medicine 6.2 (2018): 94-104. 
  47. Zaichick V and Zaichick S. “Br, Fe, Rb, Sr, and Zn levels in the prostatic secretion of patients with chronic prostatitis”. International Archives of Urology and Complications 4 (2018): 046. 
  48. Zaichick V and Zaichick S. “Trace element concentrations in the expressed prostatic secretion of normal and hyperplastic prostate”. Journal of Urology and Nephrology Studies 1.3 (2018): 1-7.
  49. Zaichick V and Zaichick S. “Trace elements of expressed prostatic secretions as a source for biomarkers of prostatic cancer”. Journal of Clinical Research in Oncology 1.1 (2018): 1-7. 
  50. Zaichick V and Zaichick S. “Age-dependence of some trace element concentrations and their ratios in human prostatic fluid”. Journal of Aging Research and Healthcare 2.4 (2019): 11-20.
  51. Zaichick V. “Using prostatic fluid levels of rubidium and zinc concentration multiplication in non-Invasive and highly accurate screening for prostate cancer”. Journal of Cancer Prevention and Current Research 10.6 (2019):151-158.
  52. Zaichick V and Zaichick S. “Using prostatic fluid levels of zinc to bromine concentration ratio in non-invasive and highly accurate screening for prostate cancer”. Journal of Hematology and Oncology Research 3.3 (2019): 21-31.
  53. Zaichick V and Zaichick S. “Using prostatic fluid levels of zinc to iron concentration ratio in non-invasive and highly accurate screening for prostate cancer”. SSRG International Journal of Medical Science 6.11 (2019): 24-31.
  54. Zaichick V and Zaichick S. “Using prostatic fluid levels of zinc to strontium concentration ratio in non-invasive and highly accurate screening for prostate cancer”. Acta Scientific Cancer Biology 4.1 (2020): 12-21.
  55. Zaichick V and Zaichick S. “A systematic review of the zinc concentrations in the prostate fluid of normal and hyperplastic gland”. Journal of Medical Biomedical and Applied Sciences 7.12 (2019): 303-311. 
  56. Zaichick V and Zaichick S. “A systematic review of the zinc concentrations in the prostate fluid of normal and cancerous gland”. Journal of Clinical Research in Oncology 2.2 (2019): 1-8. 
  57. Zaichick V and Zaichick S. “A systematic review of the zinc concentrations in the prostate fluid of normal and inflamed gland”. International Journal of Innovative Research in Medical Science 4.12 (2019):718-724. 
  58. Zaichick V. “A systematic review of the main electrolytes concentrations in the prostate fluid of normal gland”. Journal of Analytical and Pharmaceutical Research 8.6 (2019): 214-220.
  59. Zaichick V. “Using prostatic fluid levels of some trace elements and their combinations in non-Invasive and highly accurate screening for prostate cancer”. Journal of Cancer Therapy 11 (2020): 1-17.
  60. Zaichick V and Zaichick S. “A systematic review of the zinc concentrations in the prostate fluid of normal gland”. Acta Scientific Medical Sciences 4.1 (2020): 82-89. 
  61. Budagov RS., et al. “Blood trace elements as an indicator for ray exposure heaviness”. Radiobiologiya 34 (1994): 49-54.
  62. Zaichick V. “Medical elementology as a new scientific discipline”. Journal of Radioanalytical and Nuclear Chemistry 269 (2006): 303-309.
  63. Zhang J., et al. “Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility”. Scientific Reports 9.1 (2019): 15221.
  64. Littley MD., et al. “Endocrine and reproductive dysfunction following fractionated total body irradiation in adults”. Quarterly Journal of Medicine 78.287 (1991): 265-274.
  65. Ogilvy-Stuart AL and Shalet SM. “Effect of radiation on the human reproductive system”. Environmental Health Perspectives 101.2 (1993): 109-116.
  66. Kesari KK, et al. “Radiations and male fertility”. Reproductive Biology and Endocrinology 16 (2018): 118.
  67. Poorvu PD., et al. “Cancer treatment-related infertility: A critical review of the evidence”. JNCI Cancer Spectrum 3.1 (2019): 008.
  68. Zaichick V. “Applications of synthetic reference materials in the Medical Radiological Research Centre”. Fresenius Journal of Analytical Chemistry 352 (1995): 219-223.
  69. Sevankaev AV and Nasonov AP. “Biological dosimetry for chromosomal aberrations of the human lymphocyte culture”. Methodical recommendations. Medical Radiological research Centre, Obninsk (1979).
  70. Rossmann M., et al. “Determination of key chemical elements by energy dispersive X-Ray fluorescence analysis in commercially available infant and toddler formulas consumed in UK”. Nutrition and Food Technology: Open Access 2.4 (2016): 1-7. 
  71. Rana S., et al. “Radiation-induced biomarkers for the detection and assessment of absorbed radiation doses”. Journal of Pharmacy and Bioallied Sciences 2 (2010): 189-196.
×

Citation

Citation: Vladimir Zaichick and Sofia Zaichick. “Preliminary Study of Prostatic Fluid Levels of Zinc Concentration as the Biodosimeter of Males Exposure to Ionizing Radiation". Acta Scientific Medical Sciences 4.3 (2020): 01-07.



Member In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for March Issue
    The last date for submission of articles for regular Issues is February 29, 2020.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US