Acta Scientific Medical Sciences

Research ArticleVolume 2 Issue 3

Comparative Analysis of Anti-Fungal Activities of Itraconazole and Fluconazole against Blastomycosis (Bilastomyces Dermatitidis)

Baki AS1 and Bello A1*

1Department of Microbiology, Faculty of Science, Usmanu Danfodiyo University, Sokoto, Nigeria
2Department of Veterinary Anatomy, Usmanu Danfodiyo University, Sokoto, Nigeria

*Corresponding Author: Bello A, Department of Veterinary Anatomy, Usmanu Danfodiyo University, Sokoto, Nigeria.

Received: March 21, 2018; Published: May 24, 2018

Citation: Baki AS and Bello A. “Comparative Analysis of Anti-Fungal Activities of Itraconazole and Fluconazole against Blastomycosis (Bilastomyces Dermatitidis)”. Acta Scientific Medical Sciences 2.3 (2018).

Abstract

 &ndsp;Bilastomyces dermatitidis is the causal agent of blastomycosis, that causes fungal infection found occasionally in humans and other animals in regions where the fungus is endemic. The samples were collected using clean container from different sites which were river rima Sokoto, river Goronyo and fadama soil Sokoto round. The concentration of (10-2) and (10-3) of each sample were inoculated using sterile wire loop into potato dextrose agar (PDA) media. The incubation was done at incubating room for growth to take place at 30°c for 7 days under aseptic conditions. The target organism ( Blastomyces dermatitidis) was negative after isolation and identification. The non-target organisms are: Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus, Penicillium, Aureobasidium pullulans and Trichoderma harzianum were isolated. The Blastomyces dermatitidis were not found as a threat form Sokoto metropolis. Blastomyces infection has also being described in Africa. Blastomyces dermatitidis most commonly infects the lungs, followed by skin, bone, prostate and the central nervous system. It occurs more commonly in men than women because of larger of men occupational exposure. The community should be frequently visiting clinic for medical check-up. Based on the above result, it was recommended that people should avoid exposure to endemic areas. The people that had gone to endemic areas should be tested for blastomycosis when returning. The communities or individuals should report to the clinic immediately when there are abnormalities in the body for early recognition and diagnosis for proper treatment.

Keywords: Anti-fungal; Fluconazole; Blastomyces dermatitidis; Sokoto

Copyright: © 2018 ury Evgeny Razvodovsky. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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