Acta Scientific Medical Sciences

Review ArticleVolume 2 Issue 2

Alzheimer’s Disease: Multiple Causes Requiring Multiple Therapies

James D Weinstein*

Professor of Neuroscience, Joan C. Edwards Medical School, Marshall University (Retired), Huntington, West Virginia, USA

*Corresponding Author: James D Weinstein, Professor of Neuroscience, Joan C. Edwards Medical School, Marshall University (Retired), Huntington, West Virginia, USA.

Received: March 09, 2018; Published: April 16, 2018

Citation: James D Weinstein. “Alzheimer’s Disease: Multiple Causes Requiring Multiple Therapies”. Acta Scientific Medical Sciences 2.2 (2018).


  Despite years of testing for an effective Alzheimer’s therapy, no means to stop the inexorable cognitive decline characterizing Alzheimer’s patients has been found. A new approach to achieving this goal is urgently required.

  Changes should start by recognizing that late onset Alzheimer’s Disease (AD) is a disease of multiple etiologies. These require a combination of therapies directed against the major causative pathologies of the disease rather than the current standard of treating one or another of the disease etiologies with a single mono-therapy. The test end point should be whether or not treatment com- pletely stops progressive dementia. This would have two major advantages. Most important is that an effectively treated patient will no longer show a cognitive decline. They may in fact show a lessening of dementia in time, a result infinitely better than only slowing progressive cognitive decline. This article presents the methods and rationale for effecting these changes.

Keywords: Combination Therapy; Alzheimer’s Dementia; Drug Therapy; Off-Label Drugs

Copyright: © 2018 James D Weinstein. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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