Alfonso Lagi1 and Simone Cencetti2*
1Internal Medicine, Villa Donatello Hospital, Florence, Italy
2Internal Medicine, Santa Maria Nuova Hospital, Florence, Italy
*Corresponding Author: Alfonso Lagi, Internal Medicine, Villa Donatello Hospital, Florence, Italy.
Received: March 14, 2018; Published: April 14, 2018
Citation: Alfonso Lagi and Simone Cencetti. “Therapeutic Schedules in Hypertension Control: All that Every Physician Should Know”. Acta Scientific Medical Sciences 2.2 (2018).
Background: Hypertension is a leading risk factor for death and disability and guidelines and statements advice many suggestions for its control. Unfortunately, they are not enough and to handle the hypertension in real world is challenging. Overall the proportion of hypertensive individuals whose condition is treated or controlled with medication remains low but very difficult to establish.
Method: Drug treated hypertensive patients (18 - 80 yo) were enrolled. The study was done using a first group of hypertensive patients with pharmacological treatment with three or four drugs. A second comparison group was formed of hypertensives that took one or two drugs. Patients were subjected to a four-month follow-up so that they have the initial and the remote data. Side effects were considered, in particular the appearance of asthenia, syncope and/or lypothimia and a reduction in renal function. The univariate analysis was made for age, sex and for the number of drugs used vs the value of Pa. Subsequently, a multivariate analysis was performed between the significant univariate variables.
Results: The number of patients enlisted in the study was 114 (58 males, mean age 61 years). The result is that the arterial pressure mean of patients taking 3 or more drugs (52 pts) are significantly different from the others (62 pts). The second result is that exist a trend of odd ratio among the different groups estimated at 2 (CI 95% 1,38 - 3,06) for each step. In other words the increase of one drug added to previous double the probability to go at target and so to have a control of arterial pressure.
Discussion and Conclusions: Many hypertensive patients have complex form of the disease, so that their hypertension is hard to treat, due to resistant hypertension or because complicated by a range of comorbidities. More drugs major effect. This may be the most important outcome of the work. The work shows how combined treatment is much more beneficial to bring the patient to a target.
Keywords: Hypertension; Systolic Blood Pressure Intervention Trial (SPRINT); Cardiovascular Disease
Copyright: © 2018 Alfonso Lagi and Simone Cencetti. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.