Hugh J Freeman*

Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada

*Corresponding Author: Hugh J Freeman, Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada.

Received: January 17, 2024; Published: January 20, 2024

Abstract

An elderly woman presented with abdominal pain and a long-standing history of involvement of multiple organs with systemic mastocytosis. A Gastric ulcer was detected and responsive to proton pump inhibitor therapy. Although rare mast cells were detected in gastric biopsies, the ulcer was likely related to a circulating mast cell mediator, her treatment medications, or both, and not her advanced systemic mastocytosis. After resolution of her pain and complete endoscopic healing of her ulcer, ongoing anti-secretory drug therapy was provided. This report adds further evidence that gastric ulcer disease, reported in up to 50% of patients with systemic mastocytosis, may not be directly to due to the disease, but indirectly due to a circulating mast cell mediator or drug treatment for an associated clinical disorder.

Keywords: Mastocytosis; Gastric Ulceration and Gastric Involvement; Sprue-Like Intestinal Disease; Mastocytic Enterocolitis

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Citation

Citation: Hugh J Freeman. “Gastrointestinal Ulceration in Systemic Mastocytosis". Acta Scientific Gastrointestinal Disorders 7.2 (2024): 23-26.

Copyright

Copyright: © 2024 Hugh J Freeman. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.