Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 4 Issue 9

Therapeutic Pathomorphosis After Thermochemoradiotherapy of the Rectal Cancer

S Yu Ignatenkov1, I Yu Kudryavtsev1,2*, KA Kuzminykh1, OA Skugareva1 and EA Dobrosotskaya2

1Kaluga Regional Clinical Oncology Center, Kaluga, Russia
2Kaluga State University Named After K.E. Tsiolkovsky, Kaluga, Russia

*Corresponding Author: EA Dobrosotskaya, Kaluga Regional Clinical Oncology Center and Kaluga State University Named After K.E. Tsiolkovsky, Kaluga, Russia.

Received: August 05, 2021; Published: August 16, 2021

Abstract

Rectal cancer is one of the most common malignant tumors of the gastrointestinal tract. Recent studies have shown the high efficiency and impact of neoadjuvant chemoradiotherapy on the number of sphincter-preserving surgeries, and local regional control.

The article provides a review of the oncological literature in Russia devoted to the efficacy and safety of preoperative chemoradiation therapy against the background of hyperthermia in the treatment of locally advanced stage II-IV rectal cancer. In addition, the degree of therapeutic pathomorphosis in 59 patients of the Kaluga oncology clinic is considered, among whom 35 patients received radiosensitization only with chemotherapy and 24 patients additionally underwent local hyperthermia. The thermal radiation component use in combined treatment allows achieving an increase in the number of medical pathomorphosis of the III-IV degree.

Keywords: Rectal Cancer Stage II-IV; Combined Treatment; Chemotherapy; Radiation Therapy; Regional Hyperthermia

References

  1. Kaprin AD., et al. “The status of cancer care for the population of Russia in 2018”. Moscow (2019): 236.
  2. Tamrazov RI., et al. “Local hyperthermia in rectal cancer treatment: a view on the future from the past”. Oncological Coloproctology 3 (2011): 12-21.
  3. Afanasyev SG., et al “Immediate results of radical surgery under conditions of combined modality treatment of rectal cancer”. Siberian Oncology Journal1 (2016): 5-10.
  4. Ivanov SA., et al. “Direct effectiveness of adding local hyperthermia to the scheme of neoadjuvant chemoradiotherapy for locally advanced rectal cancer”. Research and Practical Medicine Journal3 (2020): 10-20.
  5. Lushnikov EF. “Radiation pathomorphism of human tumors”. M.: Medicine (1977): 327.
  6. Starodubtseva DА., et al. “Thermoradiotherapy in combined modality treatment for rectal cancer (literature review)”. Siberian Oncology Journal2 (2018): 89-94.
  7. Maluta S., et al. “Regional hyperthermia added to intensified preoperative chemo-radiation in locally advanced adenocarcinoma of middle and lower rectum”. International Journal of Hyperthermia 2 (2010): 108-117.
  8. H Sahinbas., et al. “Temperature measurements in a capacitive system of deep loco-regional hyperthermia”. Electromagnetic Biology and Medicine3 (2017): 248-258.
  9. Christopher Schroeder., et al. “Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone”. International Journal of Hyperthermia8 (2012): 707-714.

Citation

Citation: I Yu Kudryavtsev., et al. “Therapeutic Pathomorphosis After Thermochemoradiotherapy of the Rectal Cancer”. Acta Scientific Gastrointestinal Disorders 4.9 (2021): 29-33.

Copyright

Copyright: © 2021 I Yu Kudryavtsev., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor0.835

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