Comparative Evaluation of Ketorol Dt and Dan-P in Reducing Pain in Irreversible Pulpitis

Aayushi Sharma*, Shraddha Chokshi, Zarana Sanghvi and Setu Bavaria

Ahmedabad Dental College and Hospital, India

*Corresponding Author: Aayushi Sharma, Ahmedabad Dental College and Hospital, India.

Received: July 15, 2022; Published: August 10, 2022

Abstract

Paracetamol and non-steroidal anti-inflammatory drugs (e.g. ketorolac) is used to eliminate mild to moderate post operative pain. As a selective α-2 agonist adrenergic receptor of this group have analgesic and sedative effects. It is interesting to evaluate a single dose of two different analgesics having different effects, compared to each other on patients with symptomatic irreversible pulpitis. 106 patients were taken into consideration, with severe pain in the current short study. Patients were blindly divided into groups. This includes Ketorol Dt Tablet as one group and Dan-P tablet as another. Participants were questioned about the pain scores at time intervals of 6 hrs, 12 hrs, 24 hrs and 3 days. The data collected was then tested for results, using statistical significance tests. The severity of pain decreased in the two interventional groups (p < 0.01) at 3 days. Data shows that both Dan-P and Ketorol Dt groups had similar effects after 3 days but group 1 of Ketorol Dt showed significant results after 24 hours at all time intervals. Thus, a single dose of Ketorol Dt (ketorolac), an analgesic, following cleaning and shaping of root canals relieved pain at every sitting of the treatment. However, group 1, Keterol Dt gave better results during the first 6hrs after cleaing and shaping of root canals compared to the Dan-P (Diclofenac and Paracetamol/Acetaminophen).

Keywords: Paracetamol; Ketorolac; Symptomatic Irreversible Pulpitis; Dan-P; Ketorol Dt and Visual Analog Scale

Bibliography

1. Kim S. “Neurovascular interactions in the dental pulp in health and inflammation”. Journal of Endodontics 16 (1990): 48.
2. Teja KV., et al. “Regulation of matrix metalloproteinase-3 gene expression in inflammation: A molecular study”. Journal of Conservative Dentistry 21 (2018): 592.
3. Ng YL., et al. “Prevalence of and factors affecting post-obturation pain in patients undergoing root canal treatment”. International Endodontic Journal 37 (2004): 381.
4. Lipsky PE. American Journal of Orthopaedics (Belle Mead NJ). 28 (1999): 8.
5. Brogden RN and Wieseman LR. “Aceclofenac. A review of its pharmacodynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management”. Drugs 52 (1996): 113-124.
6. Jenarthanan S., et al. “Comparative evaluation of the efficacy of diclofenac sodium administered using different delivery routes in the management of endodontic pain: A randomized controlled clinical trial”. Journal of Conservative Dentistry 21 (2018): 297-301.
7. Torabinejad M., et al. “Effectiveness of various medications on postoperative pain following root canal obturation”. Journal of Endodontics 20 (1994): 427-431.
8. Menhinick KA., et al. “The efficacy of pain control following nonsurgical root canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo-controlled study”. International Endodontic Journal 37 (2004): 531-541.
9. Ruddle CJ. “The protaper advantage: shaping the future of endodontics”. Dental Today 20 (2001): 60.
10. Siddique R., et al. “Qualitative and quantitative analysis of precipitate formation following interaction of chlorhexidine with sodium hypochlorite, neem, and tulsi”. Journal of Conservative Dentistry 22 (2019): 40-47.
11. Siddique R., et al. Journal of Conservative Dentistry 22 (2019): 114.
12. Madison S., et al. “Dental Clinics of North America 36 (1992): 343.
13. Muth-Selbach US., et al. ANES 91 (1999): 231.
14. Dooley M., et al. “Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease”. Drugs 61 (2001): 1351.
15. Jyothsna K., et al. “Efficacy and Safety of Diclofenac Sodium and Aceclofenac in Controlling Post Extraction Dental Pain: A Randomised Open Label Comparative Study”. Journal of Pharmacology and Toxicology 6 (2011): 541.
16. Vohra F., et al. “Comparative efficacy, safety, and tolerability of diclofenac and aceclofenac in musculoskeletal pain management: A systematic review”. Indian Journal of Pain 30 (2016): 3-6.
17. Kohli SS., et al. “Effectiveness of piroxicam and ibuprofen premedication on orthodontic patients' pain experiences: A randomized control trial”. Angle Orthodontics 81 (2011): 1097.
18. Joshi N., et al. “Comparative evaluation of the efficacy of two modes of delivery of Piroxicam (Dolonex®) for the management of postendodontic pain: A randomized control trial”. Journal of Conservative Dentistry 19 (2016): 301-305.

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Citation: Aayushi Sharma., et al. “Comparative Evaluation of Ketorol Dt and Dan-P in Reducing Pain in Irreversible Pulpitis". Acta Scientific Dental Sciences 6.9 (2022): 11-14.

Copyright: © 2022 Aayushi Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.