Anubha Bajaj*

Department of Histopathology, Panjab University/A.B. Diagnostics, India

*Corresponding Author: Anubha Bajaj, Department of Histopathology, Panjab University/A.B. Diagnostics, India.

Received: June 18, 2024; Published: July 01, 2024

Abstract

Invasive cribriform carcinoma breast emerges as a low grade subtype of invasive carcinoma breast. Neoplasm preponderantly (>90%) delineates a pure cribriform architecture or may represent as a mixed tumour composed of 10% to 90% of variant morphological subtype. Tumefaction is constituted of islands or nests of malignant epithelial cells demonstrating spherical or angulated contours or configure well defined cribriform spaces articulated by arches of epithelial cells, thereby delineating a sieve-like appearance with intercellular lumens impregnated with secretions. Miniature tumour cells display mild to moderate pleomorphism with absent nuclear atypia. Cribriform carcinoma breast is immune reactive to oestrogen receptors (ER) or progesterone receptors (PR) and immune non reactive to HER2 or diverse myoepithelial markers. Cribriform carcinoma breast requires segregation from neoplasms as adenoid cystic carcinoma, cribriform variant of ductal carcinoma in situ, collagenous spherulosis, well differentiated neuroendocrine tumour or well differentiated invasive breast cancer of no special type (NST). Neoplasm may be appropriately ascertained by mammography or ultrasonography of the breast. Cribriform carcinoma breast may be appropriately alleviated by primary surgical eradication of the lesion.

Keywords: Low Grade; Sieve-Like; Oestrogen/ Progesterone+

References

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7. Image 1 Courtesy: Medical news today.
8. Image 2 Courtesy: Libre pathology.

Citation

Citation: Anubha Bajaj. “Sifter and Mesh-Cribriform Carcinoma Breast". Acta Scientific Clinical Case Reports 5.7 (2024): 01-04.

Copyright

Copyright: © 2024 Anubha Bajaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.