Acta Scientific Biotechnology

Research Article Volume 2 Issue 5

Analysis of IL-6 Interacting Proteins Using STRING Online Resource

Lakshmi Vandana and Krupanidhi Sreerama*

Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research, India

*Corresponding Author: Krupanidhi Sreerama, Department of Biotechnology, Vignan’s Foundation for Science, Technology and Research, India.

Received: July 15, 2021; Published: July 30, 2021


Protein-protein interaction (PPI) is one of the biological integrating communication systems. Also, biological feed-back mechanism is centred on PPI. It is furthermore important to be taken into consideration in viral diseases such as Covid-19 and consequent drug regimens leading to cytokine storm. STRING online resource ( of compiled data through machine learning tools, wide array of literature resources and embedded interactive platform aiming to explore associations among displayed proteins with combined score in predetermined parameters in the network setting box was adapted in the present study. The query protein viz., IL-6 was chosen to explore its interactions by choosing options in the setting box namely five interactors with zero and three clusters. The output indicated that the displayed network containing query IL-6 with participating five proteins shown to have significantly more interactions than predicted with a combined score of ~0.997. This study would appreciate intricacies involved in cytokine storm among Covid-19 contracted patients.

Keywords: IL-6; STRING Tool; Protein-protein Interaction; Covid-19; Cytokine Storm


  1. Tanaka T., et al. “Immunotherapeutic implications of IL-6 blockade for cytokine storm”. Immunotherapy 8 (2016): 959-970.
  2. Copaescu A., et al. “The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection”. Journal of Allergy and Clinical Immunology3 (2020): 518-534.
  3. Saha A., et al. “Tocilizumab: a therapeutic option for the treatment of cytokine storm syndrome in COVID-19”. Archives of Medical Research6 (2020): 595-597.
  4. Mitsuyama K., et al. “Therapeutic strategies for targeting the IL-6/STAT3 cytokine signalling pathway in inflammatory bowel disease”. Anticancer Research 27 (2007): 3749-3756.
  5. Rincon M and Irvin CG. “Role of IL-6 in asthma and other inflammatory pulmonary diseases”. International Journal of Biological Sciences 9 (2012): 1281.
  6. Szklarczyk D., et al. “STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets”. Nucleic Acids Research 47 (2019): d607-613.
  7. Zhang JM and An J. “Cytokines, inflammation and pain”. International Anesthesiology Clinics2 (2007): 27.
  8. Gupta S., et al. “IL-6 augments IL-4-induced polarization of primary human macrophages through synergy of STAT3, STAT6 and BATF transcription factors”. Oncoimmunology 10 (2018): e1494110.
  9. Arango Duque G and Descoteaux A. “Macrophage cytokines: involvement in immunity and infectious diseases”. Frontiers in Immunology 5 (2014): 491.
  10. Wong CK., et al. “Proinflammatory cytokines (IL 17, IL 6, IL 18 and IL 12) and Th cytokines (IFN γ, IL 4, IL 10 and IL 13) in patients with allergic asthma”. Clinical and Experimental Immunology2 (2001): 177-183.
  11. Bradding P., et al. “Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation”. The Journal of Immunology7 (1993): 3853-3865.
  12. Tarasova O., et al. “Data and text mining help identify key proteins involved in the molecular mechanisms shared by SARS-CoV-2 and HIV1”. Molecules12 (2020): 2944.
  13. Wei L., et al. “A novel machine learning method for cytokine-receptor interaction prediction”. Combinatorial Chemistry and High Throughput Screening2 (2016): 144-152.
  14. Franceschini A., et al. “STRING v9. 1: protein-protein interaction networks, with increased coverage and integration”. Nucleic Acids Research 41 (2012): D808-815.
  15. Cook HV., et al. “Viruses: STRING: a virus-host protein-protein interaction database”. Viruses 10 (2018): 519.


Citation: Lakshmi Vandana and Krupanidhi Sreerama. “Analysis of IL-6 Interacting Proteins Using STRING Online Resource”. Acta Scientific Computer Sciences 2.5 (2021): 26-30.


Copyright: © 2021 Lakshmi Vandana and Krupanidhi Sreerama. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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