Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Review Article Volume 5 Issue 7

Solutions to Post-GWAS Regulatory Variants in Bovine

Nidhi Sukhija1, Kanaka K K1, Jayakumar Sivalingam2*, Komal Jaglan3, Pallavi Rathi1, Rangasai Chandra Goli1 and Chethan Raj4

1ICAR-National Dairy Research Institute, Karnal, Haryana, India
2ICAR-Directorate of Poultry Research, Hyderabad, India
3Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
4ICAR-Indian Veterinary Research Institute, Izatnagar, UP, India

*Corresponding Author: Jayakumar Sivalingam, ICAR-Directorate of Poultry Research, Hyderabad, India.

Received: May 23, 2023; Published: June 03, 2023


Advancements in Next Generation Sequencing have led to an increased exploration of the genome and transcriptome to uncover genetic variants associated with phenotypic traits. Genome-wide association studies (GWAS) and genomic predictions play a crucial role in identifying significant genetic variants that contribute to complex traits. However, most of these variants are found in non-coding regions of the genome, making their functional annotation and interpretation challenging. This review highlights the importance of characterizing and prioritizing non-coding variants and their effects on regulatory elements in livestock genomics. Regulatory elements such as promoters, enhancers, silencers, and non-coding RNAs coordinate gene expression and are critical for understanding the underlying mechanisms of traits. The abstract also discusses various tools and methods for annotating and predicting the effects of regulatory variants, as well as validation platforms for studying their functional impact. Comprehensive functional annotation of non-coding variants is essential for gaining insights into the genetic architecture of complex traits and improving genetic selection strategies in livestock breeding programs.

Keywords: GWAS; Regulatory Variants, SNPs; Tools; RNA


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Citation: Jayakumar Sivalingam., et al. “Solutions to Post-GWAS Regulatory Variants in Bovine".Acta Scientific Veterinary Sciences 5.7 (2023): 11-15.


Copyright: © 2023 Jayakumar Sivalingam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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